New 3-, 8-disubstituted pyrazolo[5,1-c][1,2,4]benzotriazines useful for studying the interaction with the HBp-3 area (hydrogen bond point area) in the benzodiazepine site on the γ-aminobutyric acid type A (GABAA) receptor

Bioorganic and Medicinal Chemistry

Volumn 19, Issue 10, 2011, Pages 3074-3085

  Guerrini, Gabriella ^a   Ciciani, Giovanna ^a   Bruni, Fabrizio ^a   Selleri, Silvia ^a   Melani, Fabrizio ^a   Daniele, Simona ^b   Martini, Claudia ^b   Costanzo, Annarella ^a  

^a UNIVERSITY OF FLORENCE   (Italy)

^b UNIVERSITY OF PISA   (Italy)

Author keywords

Benzodiazepine binding site; GABAA receptors; Ligand based pharmacophoric model; Pyrazolo 5,1 c 1,2,4 benzotriazine system

Indexed keywords

1,2,4 BENZOTRIAZINE DERIVATIVE; 3 (2 THIENYLMETHOXYCARBONYL) 8 (4 METHOXYPHENYL)PYRAZOLO [5,1 C][1,2,4] BENZOTRIAZINE 5 OXIDE; 3 (FUR 2 YL) 8 (THIEN 3 YL)PYRAZOLO [5,1 C][1,2,4] BENZOTRIAZINE 5 OXIDE; 3 (FUR 2 YLCARBONYL) 8 (4 METHOXYPHENYL)PYRAZOLO [5,1 C][1,2,4] BENZOTRIAZINE 5 OXIDE; 3 (FUR 2 YLCARBONYL) 8 IODOPYRAZOLO [5,1 C][1,2,4] BENZOTRIAZINE 5 OXIDE; 3 (THIEN 3 YL) 8 (4 METHOXYPHENYL)PYRAZOLO [5,1 C][1,2,4] BENZOTRIAZINE 5 OXIDE; 3 (THIEN 3 YL) 8 (FUR 2 YL)PYRAZOLO [5,1 C][1,2,4] BENZOTRIAZINE 5 OXIDE; 3 (THIEN 3 YL) 8 (PYRROL 2 YL)PYRAZOLO [5,1 C][1,2,4] BENZOTRIAZINE 5 OXIDE; 3 (THIEN 3 YL) 8 (THIEN 2 YL)PYRAZOLO [5,1 C][1,2,4] BENZOTRIAZINE 5 OXIDE; 3 (THIEN 3 YL) 8 (THIEN 3 YL)PYRAZOLO [5,1 C][1,2,4] BENZOTRIAZINE 5 OXIDE; 3 (THIEN 3 YL) 8 PHENYLPYRAZOLO [5,1 C][1,2,4] BENZOTRIAZINE 5 OXIDE; 3 IODO 8 (2 HYDROXYPHENYL)PYRAZOLO [5,1 C][1,2,4] BENZOTRIAZINE 5 OXIDE; 3 IODO 8 (2 METHOXYPHENYL)PYRAZOLO [5,1 C][1,2,4] BENZOTRIAZINE 5 OXIDE; 3 IODO 8 (4 METHOXYPHENYL)PYRAZOLO [5,1 C][1,2,4] BENZOTRIAZINE 5 OXIDE; 3 IODO 8 (4 PYRIDYL)PYRAZOLO [5,1 C][1,2,4] BENZOTRIAZINE 5 OXIDE; 3 IODO 8 (8 THIEN 2 YL)PYRAZOLO [5,1 C][1,2,4] BENZOTRIAZINE 5 OXIDE; 3 IODO 8 (8 THIEN 3 YL)PYRAZOLO [5,1 C][1,2,4] BENZOTRIAZINE 5 OXIDE; 3 IODO 8 (FUR 2 YL)PYRAZOLO [5,1 C][1,2,4] BENZOTRIAZINE 5 OXIDE; 3 IODO 8 (PYRROL 2 YL)PYRAZOLO [5,1 C][1,2,4] BENZOTRIAZINE 5 OXIDE; 3,8 DISUBSTITUTED PYRAZOLO [5,1 C][1,2,4] BENZOTRIAZINE DERIVATIVE; 4 AMINOBUTYRIC ACID A RECEPTOR; 8 (2 METHOXYPHENYL)PYRAZOLO [5,1 C][1,2,4] BENZOTRIAZINE 5 OXIDE; 8 (4 METHOXYPHENYL)PYRAZOLO [5,1 C][1,2,4] BENZOTRIAZINE 5 OXIDE; 8 (4 PYRIDYL)PYRAZOLO [5,1 C][1,2,4] BENZOTRIAZINE 5 OXIDE; 8 (FUR 2 YLCARBONYL)PYRAZOLO [5,1 C][1,2,4] BENZOTRIAZINE 5 OXIDE; 8 (THIEN 2 YL)PYRAZOLO [5,1 C][1,2,4] BENZOTRIAZINE 5 OXIDE; 8 (THIEN 3 YL)PYRAZOLO [5,1 C][1,2,4] BENZOTRIAZINE 5 OXIDE; BENZODIAZEPINE; ETHYL 1 [2 NITRO 5 (FUR 2 YL)PHENYL] 5 AMINOPYRAZOL 4 CARBOXYLATE; UNCLASSIFIED DRUG; UNINDEXED DRUG;

ANIMAL EXPERIMENT; ARTICLE; BINDING AFFINITY; BINDING SITE; CONTROLLED STUDY; CYCLIZATION; DRUG STRUCTURE; DRUG SYNTHESIS; GABAERGIC SYSTEM; HYDROGEN BOND; HYDROPHILICITY; LIGAND BINDING; MELTING POINT; MOLECULAR MODEL; MOUSE; NONHUMAN; PHARMACOPHORE; STRUCTURE ACTIVITY RELATION; SUZUKI REACTION;

ANIMALS; BINDING SITES; CATTLE; CEREBRAL CORTEX; HYDROGEN BONDING; MODELS, MOLECULAR; PROTEIN BINDING; PYRAZOLES; RECEPTORS, GABA-A; TRIAZINES;

EID: 79956195898     PISSN: 09680896     EISSN: 14643391     Source Type: Journal    
DOI: 10.1016/j.bmc.2011.04.009     Document Type: Article

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