Human plasminogen catalytic domain undergoes an unusual conformational change upon activation

Journal of Molecular Biology

Volumn 295, Issue 4, 2000, Pages 903-914

  Wang, Xiaoqiang ^a   Terzyan, Simon ^a   Tang, Jordan ^a,b   Loy, Jeffrey A ^a,b   Lin, Xinli ^a   Zhang, Xuejun C ^a  

^a OKLAHOMA MEDICAL RESEARCH FOUNDATION   (United States)

^b UNIVERSITY OF OKLAHOMA COLLEGE OF MEDICINE   (United States)

Author keywords

Crystal structure; Plasminogen; Zymogen activation

Indexed keywords

ENZYME PRECURSOR; PLASMIN; PLASMINOGEN; SERINE PROTEINASE; TRYPSIN;

AMINO ACID SEQUENCE; ARTICLE; BLOOD CLOT LYSIS; CELL MIGRATION; CONFORMATIONAL TRANSITION; CRYSTAL STRUCTURE; ENZYME ACTIVATION; ENZYME ACTIVE SITE; ENZYME CONFORMATION; ENZYME STRUCTURE; FIBRINOLYSIS; HUMAN; HUMAN CELL; METASTASIS; PRIORITY JOURNAL; STRUCTURE ANALYSIS;

EID: 0034723145     PISSN: 00222836     EISSN: None     Source Type: Journal    
DOI: 10.1006/jmbi.1999.3397     Document Type: Article

References (53)

1. The plasminogen-plasmin enzyme system
2. The CCP4 suite: Programs for protein crystallography
3. ALSCRIPT a tool to format multiple sequence alignments
4. Induction of the bovine trypsonogen-trypsin transition by peptides sequential similar to the N terminus of trypsin
5. The refined 1.9 Å crystal structure of human alpha-thrombin: Interaction with D-Phe-Pro-Arg chloromethylketone and significance of the Tyr-Pro-Pro-Trp insertion segment
6. Crystallographic R factor refinement by molecular dynamics
7. Kringle domains of human angiostatin
8. A unique enzyme-protein substrate modifier reaction: Plasmin/streptokinase interaction
9. Structure and ligand binding determinants of the recombinant kringle 5 domain of human plasminogen
10. Plasminogen activators, integrins, and the coordinated regulation of cell adhesion and migration
11. Crystal structure of the NK1 fragment of HGF/SF suggests a novel mode for growth factor dimerization and receptor binding
12. Plasminogen is required for efficient dissemination of B. burgdorferi in ticks and for enhancement of spirochetemia in mice
13. Molecular basis of fibrinolysis, as relevant for thrombolytic therapy
14. Analysis of the interactions between streptokinase domains and human plasminogen
15. Proteases and protease inhibitors in tumor progression
16. Thrombolytic therapy in the treatment of stroke
17. Crystal structure of bovine trypsinogen at 1.8 Å resolution. II. Crystallographic refinement, refined structure and comparison with bovine trypsin
18. Chymotrypsin: 2.5 Å Crystal structure, comparison with alpha-chymotrypsin, and implication for zymogen activation
19. Synthesis and properties of cyclic peptides containing the activation site for plasminogen
20. The amino-terminal sequence of streptokinase and its functional implications in plasminogen activation
21. Complete amino acid sequence of streptokinase and its homology with serine proteases
22. Improved methods for building protein models in electron density maps and location of errors in these models
23. MOLSCRIPT - A program to produce both detailed and schematic plots of protein structures
24. PROCHECK: A program to check the stereochemical quality of protein structures
25. Relationships of human immunodeficiency virus protease with eukaryotic aspartic proteases
26. Elimination of the Cys558-Cys556 bond in Lys78-plasminogen, effect on activation and fibrin interaction
27. Serpin-resistant mutants of human tissue-type plasminogen activator
28. Converting tissue plasminogen activator to zymogen: A regulatory triad of Asp-His-Ser
29. Substrate specificity of tissue type plasminogen activator. Characterization of the fibrin independent specificity of t-PA for plasminogen
30. The geometry of the reactive site and of the peptide groups in trypsin, trypsinogen and its complexes with inhibitors
31. Alpha-chymotrypsin structure at 2.0 Å resolution
32. Crystal structures of the recombinant kringle 1 domain of human plasminogen in complexes with the ligands epsilon-amino-caproic acid and trans-4-(aminomethyl) cyclohexane-1-carboxylic acid
33. The mechanism of activation of human plasminogen by streptokinase
34. Raster3D version 2.0: A program for photorealistic molecular graphics
35. Plasminogen activators and matrix metalloproteinases in angiogenesis
36. Crystal and molecular structure of human plasminogen kringle 4 refined at 1.9 Å resolution
37. Mechanisms for pro matric metalloproteinase activation
38. Structure of human factor D. A complement system protein at 2.0 angstrom resolution
39. AMoRe: An automated package for molecular replacement
40. Protein folding and association: Insights from the interfacial and thermodynamic properties of hydrocarbons
41. Processing of X-ray diffraction data collected in oscillation mode
42. The ternary microplasmin-staphylokinase-microplasmin complex is a proteinase-cofactor-substrate complex in action
43. Crystal structure of the proenzyme domain of plasminogen
44. Three-dimensional structure of staphylokinase, a plasminogen activator with therapeutic potential
45. Lysine 156 promotes the anomalous proenzyme activity of tPA: X-ray crystal structure of single-chain human tPA
46. The structure of bovine trypsin: Electron density maps of the inhibited enzyme at 5 Å and at 2.7 Å resolution
47. Activation of human plasminogen by recombinant staphylokinase
48. Ovulation as a tissue remodeling process. Proteolysis and cumulus expansion
49. The isomorphous structures of prethrombin 2, hirugen-, and PPACK-thrombin: Changes accompanying activation and exosite binding to thrombin
50. Deletion of Ile1 changes the mechanism of streptokinase: Evidence for the molecular sexuality hypothesis
51. Crystal structure of the catalytic domain of human plasmin complexed with streptokinase
52. Contact activation triggers stimulation of the monocyte 5-lipoxygenase pathway via plasmin
53. Trimeresurus stejnegeri snake venom plasminogen activator