Structures of native and complexed complement factor D: Implications of the atypical His57 conformation and self-inhibitory loop in the regulation of specific serine protease activity

Journal of Molecular Biology

Volumn 282, Issue 5, 1998, Pages 1061-1081

  Jing, Hua ^a   Babu, Y Sudhakara ^b   Moore, Dwight ^a   Kilpatrick, J Michael ^b   Liu, Xiao Ying ^c   Volanakis, John E ^c   Narayana, Sthanam V L ^a  

^a UNIVERSITY OF ALABAMA AT BIRMINGHAM   (United States)

^b Biocryst Pharmaceutical Inc   (United States)

^c The University of Alabama at Birmingham   (United States)

Author keywords

Complement factor D; Drug design; Protein structure; Serine protease; X ray crystallography

Indexed keywords

ARGININE; ASPARTIC ACID; COMPLEMENT FACTOR D; ENZYME PRECURSOR; HISTIDINE; SERINE PROTEINASE;

ARTICLE; COMPLEMENT SYSTEM; CONFORMATIONAL TRANSITION; ENZYME SPECIFICITY; HUMAN; PRIORITY JOURNAL; STRUCTURE ACTIVITY RELATION;

EID: 0032500627     PISSN: 00222836     EISSN: None     Source Type: Journal    
DOI: 10.1006/jmbi.1998.2089     Document Type: Article

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