The crystal structure of isopenicillin N synthase with δ-(l-α- aminoadipoyl)-l-cysteinyl-d-methionine reveals thioether coordination to iron

Archives of Biochemistry and Biophysics

Volumn 516, Issue 2, 2011, Pages 103-107

  Clifton, Ian J ^a   Ge, Wei ^a   Adlington, Robert M ^a   Baldwin, Jack E ^a   Rutledge, Peter J ^b  

^a UNIVERSITY OF OXFORD   (United Kingdom)

^b UNIVERSITY OF SYDNEY   (Australia)

Author keywords

Antibiotics; Biosynthesis; Enzyme mechanism; Metalloenzymes; Non heme iron oxidase; Penicillin

Indexed keywords

AMINO ACID DERIVATIVE; DELTA(LEVO ALPHA AMINOADIPOYL)LEVO CYSTEINYL DEXTRO METHIONINE; HYDROCARBON; IRON; ISOPENICILLIN N SYNTHETASE; METHIONINE; SULFIDE; SULFUR; UNCLASSIFIED DRUG;

AMINO ACID SYNTHESIS; ARTICLE; CATALYSIS; CRYSTAL STRUCTURE; ENZYME ACTIVE SITE; IRON BINDING CAPACITY; PRIORITY JOURNAL; PROTEIN BINDING; STRUCTURE ANALYSIS;

CATALYTIC DOMAIN; CRYSTALLOGRAPHY, X-RAY; IRON; METHIONINE; MODELS, MOLECULAR; OLIGOPEPTIDES; OXIDOREDUCTASES; STATIC ELECTRICITY; SUBSTRATE SPECIFICITY; SULFIDES;

EID: 81755185446     PISSN: 00039861     EISSN: 10960384     Source Type: Journal    
DOI: 10.1016/j.abb.2011.09.014     Document Type: Article

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