Unique binding of a non-natural L,L,L-substrate by isopenicillin N synthase

Biochemical and Biophysical Research Communications

Volumn 336, Issue 2, 2005, Pages 702-708

  Howard Jones, Annaleise R ^a,c   Rutledge, Peter J ^b   Clifton, Ian J ^a   Adlington, Robert M ^a   Baldwin, Jack E ^a  

^a UNIVERSITY OF OXFORD   (United Kingdom)

^b UNIVERSITY COLLEGE DUBLIN   (Ireland)

^c HARVARD MEDICAL SCHOOL   (United States)

Author keywords

Antibiotics; Crystal structure; Isopenicillin N synthase; L,L,L Tripeptide; Metalloenzyme; Penicillin biosynthesis

Indexed keywords

ENZYME; FLUORINE DERIVATIVE; HEXAFLUOROVALINE DERIVATIVE; IRON OXIDASE; ISOPENICILLIN N SYNTHETASE; TRIPEPTIDE; UNCLASSIFIED DRUG;

ARTICLE; CATALYSIS; CONFORMATION; CRYSTAL STRUCTURE; DIASTEREOISOMER; OXIDATION; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN INTERACTION;

BINDING SITES; COMPUTER SIMULATION; ENZYME ACTIVATION; MODELS, CHEMICAL; MODELS, MOLECULAR; OXIDOREDUCTASES; PROTEIN BINDING; PROTEIN CONFORMATION; SUBSTRATE SPECIFICITY;

EID: 24644507972     PISSN: 0006291X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bbrc.2005.08.155     Document Type: Article

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