Interactions of isopenicillin N synthase with cyclopropyl-containing substrate analogues reveal new mechanistic insight

Biochemistry

Volumn 46, Issue 16, 2007, Pages 4755-4762

  Howard Jones, Annaleise R ^a,b   Elkins, Jonathan M ^a,c   Clifton, Ian J ^a   Roach, Peter L ^a,d   Adlington, Robert M ^a   Baldwin, Jack E ^a   Rutledge, Peter J ^a,e  

^a UNIVERSITY OF OXFORD   (United Kingdom)

^b HARVARD MEDICAL SCHOOL   (United States)

^c UNIVERSITY OF OXFORD   (United Kingdom)

^d UNIVERSITY OF SOUTHAMPTON   (United Kingdom)

^e UNIVERSITY OF SYDNEY   (Australia)

Author keywords

[No Author keywords available]

Indexed keywords

CEPHALOSPORIN; ISOPENICILLIN N SYNTHASE (IPNS); SUBSTRATE ORIENTATION; WATER OCCUPANCY;

BIOSYNTHESIS; CATALYSIS; CRYSTAL STRUCTURE; DRUG PRODUCTS; MOLECULAR DYNAMICS; PHASE TRANSITIONS;

ENZYMES;

CEPHALOSPORIN; CYCLOPROPANE DERIVATIVE; DELTA (ALPHA AMINOADIPOYL)CYSTEINYL BETA METHYL DEXTRO CYCLOPROPYLGLYCINE; DELTA (ALPHA AMINOADIPOYL)CYSTEINYL DEXTRO CYCLOPROPYLGLYCINE; DELTA (ALPHA AMINOADIPOYL)CYSTEINYL DEXTRO VALINE; ISOPENICILLIN N SYNTHETASE; NONHEME IRON PROTEIN; PENICILLIN G; TRIPEPTIDE; UNCLASSIFIED DRUG;

ARTICLE; ASPERGILLUS; CATALYSIS; CHEMICAL STRUCTURE; CRYSTAL STRUCTURE; ENERGY TRANSFER; MOLECULAR INTERACTION; NONHUMAN; PRIORITY JOURNAL; X RAY CRYSTALLOGRAPHY;

ASPERGILLUS NIDULANS; CRYSTALLIZATION; CRYSTALLOGRAPHY, X-RAY; MODELS, MOLECULAR; OLIGOPEPTIDES; OXIDOREDUCTASES;

EID: 34247541678     PISSN: 00062960     EISSN: None     Source Type: Journal    
DOI: 10.1021/bi062314q     Document Type: Article

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