Structural studies on the reaction of isopenicillin N synthase with the substrate analogue δ-(L-α-aminoadipoyl)-L-cysteinyl-D-α-aminobutyrate

Biochemical Journal

Volumn 372, Issue 3, 2003, Pages 687-693

  Long, Alexandra J ^a   Clifton, Ian J ^a   Roach, Peter L ^a,b   Baldwin, Jack E ^a   Schofield, Christopher J ^a   Rutledge, Peter J ^a,c  

^a UNIVERSITY OF OXFORD   (United Kingdom)

^b UNIVERSITY OF SOUTHAMPTON   (United Kingdom)

^c UNIVERSITY COLLEGE DUBLIN   (Ireland)

Author keywords

lactam antibiotic; Non haem iron enzyme; Oxidase; Penicillin biosynthesis

Indexed keywords

BIOSYNTHESIS; CRYSTAL STRUCTURE; CRYSTALLOGRAPHY; MATHEMATICAL MODELS;

TRIPEPTIDES;

IRON COMPOUNDS;

BETA LACTAM DERIVATIVE; BUTYRIC ACID DERIVATIVE; CEPHAM; DELTA(ALPHA AMINOADIPOYL)CYSTEINYL DEXTRO ALPHA AMINOBUTYRATE; FERROUS ION; ISOPENICILLIN N SYNTHETASE; NITRIC OXIDE; PENAM DERIVATIVE; UNCLASSIFIED DRUG;

ARTICLE; CRYSTAL STRUCTURE; CRYSTALLOGRAPHY; ENZYME ANALYSIS; ENZYME STRUCTURE; MOLECULAR MODEL; OUTCOMES RESEARCH; PRIORITY JOURNAL; REACTION ANALYSIS; STRUCTURE ANALYSIS;

BINDING SITES; CRYSTALLOGRAPHY, X-RAY; FERROUS COMPOUNDS; MODELS, MOLECULAR; MOLECULAR CONFORMATION; NITRIC OXIDE; OLIGOPEPTIDES; OXIDOREDUCTASES; STREPTOMYCES; STRUCTURE-ACTIVITY RELATIONSHIP; SUBSTRATE SPECIFICITY; THERMODYNAMICS;

EID: 0038266917     PISSN: 02646021     EISSN: None     Source Type: Journal    
DOI: 10.1042/BJ20021627     Document Type: Article

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