Crystallographic studies on the binding of selectively deuterated LLD- and LLL-substrate epimers by isopenicillin N synthase

Biochemical and Biophysical Research Communications

Volumn 398, Issue 4, 2010, Pages 659-664

  Ge, Wei ^a   Clifton, Ian J ^a   Stok, Jeanette E ^a   Adlington, Robert M ^a   Baldwin, Jack E ^a   Rutledge, Peter J ^b  

^a UNIVERSITY OF OXFORD   (United Kingdom)

^b UNIVERSITY OF SYDNEY   (Australia)

Author keywords

Antibiotics; Biosynthesis; Enzyme mechanism; Metalloenzymes; Non heme iron oxidase; Penicillin

Indexed keywords

CEPHAM DERIVATIVE; DELTA ALPHA AMINOADIPOYL CYSTEINYL VALINE; ISOPENICILLIN N SYNTHETASE; PENAM DERIVATIVE; TRIPEPTIDE; UNCLASSIFIED DRUG;

ARTICLE; COMPLEX FORMATION; CRYSTAL STRUCTURE; CRYSTALLOGRAPHY; ENZYME ACTIVE SITE; ENZYME ACTIVITY; ENZYME BINDING; ENZYME STRUCTURE; ENZYME SUBSTRATE; EPIMER; PEPTIDE SYNTHESIS; PRIORITY JOURNAL; PROTEIN BINDING; STEREOCHEMISTRY; TURNOVER TIME;

CATALYTIC DOMAIN; CRYSTALLOGRAPHY, X-RAY; DEUTERIUM; OLIGOPEPTIDES; OXIDOREDUCTASES;

EID: 77955425079     PISSN: 0006291X     EISSN: 10902104     Source Type: Journal    
DOI: 10.1016/j.bbrc.2010.06.129     Document Type: Article

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