Active-site-mediated elimination of hydrogen fluoride from a fluorinated substrate analogue by isopenicillin N synthase

Biochemical Journal

Volumn 382, Issue 2, 2004, Pages 659-666

  Grummitt, Annaleise R ^a   Rutledge, Peter J ^a,b   Clifton, Ian J ^a   Baldwin, Jack E ^a  

^a UNIVERSITY OF OXFORD   (United Kingdom)

^b UNIVERSITY COLLEGE DUBLIN   (Ireland)

Author keywords

lactam antibiotic; Fluoride elimination; Lewis acid; Non haem iron oxidase; Penicillin biosynthesis

Indexed keywords

AMINO ACIDS; CATALYSIS; CRYSTALS; ENZYMES; IRON OXIDES;

ACTIVE SITE; HYDROGEN FLUORIDE; IRON OXIDASE;

PROTEINS;

DELTA (ALPHA AMINOADIPOYL)CYSTEINYL DEXTRO BETA FLUOROVALINE; DIPEPTIDE; HYDROFLUORIC ACID; ISOPENICILLIN N SYNTHETASE; LEWIS ACID; UNCLASSIFIED DRUG;

ARTICLE; CATALYSIS; CONFORMATION; CRYSTAL STRUCTURE; ELIMINATION REACTION; ENZYME ACTIVE SITE; ENZYME ACTIVITY; ENZYME SUBSTRATE; ENZYME SYNTHESIS; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; PRIORITY JOURNAL; X RAY CRYSTALLOGRAPHY;

ANAEROBIOSIS; BINDING SITES; CRYSTALLOGRAPHY, X-RAY; FLUORIDES; HYDROFLUORIC ACID; MODELS, STRUCTURAL; OLIGOPEPTIDES; OXIDOREDUCTASES; PROTEIN INTERACTION MAPPING; SUBSTRATE SPECIFICITY; VALINE;

EID: 4544226585     PISSN: 02646021     EISSN: None     Source Type: Journal    
DOI: 10.1042/BJ20040529     Document Type: Article

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