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ChemBioChem

Volumn 8, Issue 16, 2007, Pages 2003-2007

A cyclobutanone analogue mimics penicillin in binding to isopenicillin N synthase

(5) Stewart, Amanda C a,c Clifton, Ian J a Adlington, Robert M a Baldwin, Jack E a Rutledge, Peter J b

a UNIVERSITY OF OXFORD (United Kingdom)

b UNIVERSITY OF SYDNEY (Australia)

c EVOTEC UK LTD (United Kingdom)

Author keywords

Antibiotics; Biosynthesis; Metalloenzymes; Non heme iron; Protein structures

Indexed keywords

CARBOXYLIC ACID; CYCLOBUTANONE DERIVATIVE; ISOPENICILLIN N SYNTHETASE; PENICILLIN G;

ARTICLE; BIOSYNTHESIS; CRYSTAL STRUCTURE; CRYSTALLIZATION; HYDROGEN BOND; PRIORITY JOURNAL;

BINDING SITES; CRYSTALLOGRAPHY, X-RAY; CYCLOBUTANES; HYDROGEN BONDING; MODELS, MOLECULAR; MOLECULAR CONFORMATION; OXIDOREDUCTASES; PENICILLINS; STEREOISOMERISM;

EID: 37549010371 PISSN: 14394227 EISSN: 14397633 Source Type: Journal
DOI: 10.1002/cbic.200700176 Document Type: Article

Times cited : (21)

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