메뉴 건너뛰기




Volumn 585, Issue 23, 2011, Pages 3758-3763

Role of CD8 T cell subsets in the pathogenesis of multiple sclerosis

Author keywords

Autoimmunity; CD8 T cell; Central nervous system; Experimental autoimmune encephalomyelitis; Multiple sclerosis

Indexed keywords

CD45RA ANTIGEN; CHEMOKINE RECEPTOR CCR7; GAMMA INTERFERON; GLATIRAMER; HLA A3 ANTIGEN; HLA G ANTIGEN; INTERLEUKIN 10; INTERLEUKIN 17;

EID: 81755173556     PISSN: 00145793     EISSN: 18733468     Source Type: Journal    
DOI: 10.1016/j.febslet.2011.08.047     Document Type: Review
Times cited : (55)

References (98)
  • 1
    • 54149084585 scopus 로고    scopus 로고
    • Multiple sclerosis
    • A. Compston, and A. Coles Multiple sclerosis Lancet 372 2008 1502 1517
    • (2008) Lancet , vol.372 , pp. 1502-1517
    • Compston, A.1    Coles, A.2
  • 2
    • 17644396349 scopus 로고    scopus 로고
    • Immunology of multiple sclerosis
    • DOI 10.1146/annurev.immunol.23.021704.115707
    • M. Sospedra, and R. Martin Immunology of multiple sclerosis Annu. Rev. Immunol. 23 2005 683 747 (Pubitemid 40563183)
    • (2005) Annual Review of Immunology , vol.23 , pp. 683-747
    • Sospedra, M.1    Martin, R.2
  • 4
    • 80051684615 scopus 로고    scopus 로고
    • Genetic risk and a primary role for cell-mediated immune mechanisms in multiple sclerosis
    • S. Sawcer Genetic risk and a primary role for cell-mediated immune mechanisms in multiple sclerosis Nature 476 2011 214 219
    • (2011) Nature , vol.476 , pp. 214-219
    • Sawcer, S.1
  • 6
    • 0030880011 scopus 로고    scopus 로고
    • Treatment of multiple sclerosis with the monoclonal anti-CD4 antibody cM-T412: Results of a randomized, double-blind, placebo-controlled, MR-monitored phase II trial
    • B.W. Van Oosten Treatment of multiple sclerosis with the monoclonal anti-CD4 antibody cM-T412: results of a randomized, double-blind, placebo-controlled, MR-monitored phase II trial Neurology 49 1997 351 357
    • (1997) Neurology , vol.49 , pp. 351-357
    • Van Oosten, B.W.1
  • 8
    • 67349179231 scopus 로고    scopus 로고
    • From genes to function: The next challenge to understanding multiple sclerosis
    • L. Fugger, M.A. Friese, and J.I. Bell From genes to function: the next challenge to understanding multiple sclerosis Nat. Rev. Immunol. 9 2009 408 417
    • (2009) Nat. Rev. Immunol. , vol.9 , pp. 408-417
    • Fugger, L.1    Friese, M.A.2    Bell, J.I.3
  • 9
    • 0033975139 scopus 로고    scopus 로고
    • Multiple sclerosis: A modifying influence of HLA class I genes in an HLA class II associated autoimmune disease
    • DOI 10.1034/j.1399-0039.2000.550205.x
    • A. Fogdell-Hahn, A. Ligers, M. Gronning, J. Hillert, and O. Olerup Multiple sclerosis: A modifying influence of HLA class I genes in an HLA class II associated autoimmune disease Tissue Antigens 55 2000 140 148 (Pubitemid 30103439)
    • (2000) Tissue Antigens , vol.55 , Issue.2 , pp. 140-148
    • Fogdell-Hahn, A.1    Ligers, A.2    Gronning, M.3    Hillert, J.4    Olerup, O.5
  • 12
    • 80051873375 scopus 로고    scopus 로고
    • CD8(+) T cells: Foot soldiers of the immune system
    • N. Zhang, and M.J. BeVan CD8(+) T cells: foot soldiers of the immune system Immunity 35 2011 161 168
    • (2011) Immunity , vol.35 , pp. 161-168
    • Zhang, N.1    BeVan, M.J.2
  • 13
    • 0033554726 scopus 로고    scopus 로고
    • Two subsets of memory T lymphocytes with distinct homing potentials and effector functions
    • F. Sallusto, D. Lenig, R. Forster, M. Lipp, and A. Lanzavecchia Two subsets of memory T lymphocytes with distinct homing potentials and effector functions Nature 401 1999 708 712
    • (1999) Nature , vol.401 , pp. 708-712
    • Sallusto, F.1    Lenig, D.2    Forster, R.3    Lipp, M.4    Lanzavecchia, A.5
  • 15
    • 0035348246 scopus 로고    scopus 로고
    • Naive CTLs require a single brief period of antigenic stimulation for clonal expansion and differentiation
    • M.J. Van Stipdonk, E.E. Lemmens, and S.P. Schoenberger Naive CTLs require a single brief period of antigenic stimulation for clonal expansion and differentiation Nat. Immunol. 2 2001 423 429 (Pubitemid 33706140)
    • (2001) Nature Immunology , vol.2 , Issue.5 , pp. 423-429
    • Van Stipdonk, M.J.B.1    Lemmens, E.E.2    Schoenberger, S.P.3
  • 16
    • 0028960040 scopus 로고
    • Cytokine-induced differentiation of precursor mouse CD8+ T cells into cytotoxic CD8+ T cells secreting Th1 or Th2 cytokines
    • S. Sad, R. Marcotte, and T.R. Mosmann Cytokine-induced differentiation of precursor mouse CD8+ T cells into cytotoxic CD8+ T cells secreting Th1 or Th2 cytokines Immunity 2 1995 271 279
    • (1995) Immunity , vol.2 , pp. 271-279
    • Sad, S.1    Marcotte, R.2    Mosmann, T.R.3
  • 17
    • 69249092613 scopus 로고    scopus 로고
    • A Th17-like developmental process leads to CD8(+) Tc17 cells with reduced cytotoxic activity
    • M. Huber A Th17-like developmental process leads to CD8(+) Tc17 cells with reduced cytotoxic activity Eur. J. Immunol. 39 2009 1716 1725
    • (2009) Eur. J. Immunol. , vol.39 , pp. 1716-1725
    • Huber, M.1
  • 18
    • 60749107176 scopus 로고    scopus 로고
    • The interleukin 23 receptor is essential for the terminal differentiation of interleukin 17-producing effector T helper cells in vivo
    • M.J. McGeachy The interleukin 23 receptor is essential for the terminal differentiation of interleukin 17-producing effector T helper cells in vivo Nat. Immunol. 10 2009 314 324
    • (2009) Nat. Immunol. , vol.10 , pp. 314-324
    • McGeachy, M.J.1
  • 19
    • 0035937587 scopus 로고    scopus 로고
    • Preferential localization of effector memory cells in nonlymphoid tissue
    • DOI 10.1126/science.1058867
    • D. Masopust, V. Vezys, A.L. Marzo, and L. Lefrancois Preferential localization of effector memory cells in nonlymphoid tissue Science 291 2001 2413 2417 (Pubitemid 32231804)
    • (2001) Science , vol.291 , Issue.5512 , pp. 2413-2417
    • Masopust, D.1    Vezys, V.2    Marzo, A.L.3    Lefrancois, L.4
  • 20
    • 79956119017 scopus 로고    scopus 로고
    • Regional and mucosal memory T cells
    • B.S. Sheridan, and L. Lefrancois Regional and mucosal memory T cells Nat. Immunol. 12 2011 485 491
    • (2011) Nat. Immunol. , vol.12 , pp. 485-491
    • Sheridan, B.S.1    Lefrancois, L.2
  • 21
    • 1542644156 scopus 로고    scopus 로고
    • + T Cell Trafficking to Inflamed Skin: Role for Tissue Microenvironment and Dendritic Cells in Establishment of T Cell-Homing Subsets
    • J.C. Dudda, J.C. Simon, and S. Martin Dendritic cell immunization route determines CD8+ T cell trafficking to inflamed skin: role for tissue microenvironment and dendritic cells in establishment of T cell-homing subsets J. Immunol. 172 2004 857 863 (Pubitemid 38113742)
    • (2004) Journal of Immunology , vol.172 , Issue.2 , pp. 857-863
    • Dudda, J.C.1    Simon, J.C.2    Martin, S.3
  • 22
    • 33748449719 scopus 로고    scopus 로고
    • + T Cell Trafficking after Live Viral Immunization
    • DOI 10.1016/j.immuni.2006.06.019, PII S107476130600389X
    • L. Liu, R.C. Fuhlbrigge, K. Karibian, T. Tian, and T.S. Kupper Dynamic programming of CD8+ T cell trafficking after live viral immunization Immunity 25 2006 511 520 (Pubitemid 44354216)
    • (2006) Immunity , vol.25 , Issue.3 , pp. 511-520
    • Liu, L.1    Fuhlbrigge, R.C.2    Karibian, K.3    Tian, T.4    Kupper, T.S.5
  • 24
    • 0033517288 scopus 로고    scopus 로고
    • Rapid on/off cycling of cytokine production by virus-specific CD8+ T cells
    • M.K. Slifka, F. Rodriguez, and J.L. Whitton Rapid on/off cycling of cytokine production by virus-specific CD8+ T cells Nature 401 1999 76 79
    • (1999) Nature , vol.401 , pp. 76-79
    • Slifka, M.K.1    Rodriguez, F.2    Whitton, J.L.3
  • 25
    • 0023693918 scopus 로고
    • Dual-label immunocytochemistry of the active multiple sclerosis lesion: Major histocompatibility complex and activation antigens
    • T. Hayashi, C. Morimoto, J.S. Burks, C. Kerr, and S.L. Hauser Dual-label immunocytochemistry of the active multiple sclerosis lesion: major histocompatibility complex and activation antigens Ann. Neurol. 24 1988 523 531
    • (1988) Ann. Neurol. , vol.24 , pp. 523-531
    • Hayashi, T.1    Morimoto, C.2    Burks, J.S.3    Kerr, C.4    Hauser, S.L.5
  • 26
    • 0026335135 scopus 로고
    • Astrocyte expression of major histocompatibility complex gene products in multiple sclerosis brain tissue obtained by stereotactic biopsy
    • R.M. Ransohoff, and M.L. Estes Astrocyte expression of major histocompatibility complex gene products in multiple sclerosis brain tissue obtained by stereotactic biopsy Arch. Neurol. 48 1991 1244 1246
    • (1991) Arch. Neurol. , vol.48 , pp. 1244-1246
    • Ransohoff, R.M.1    Estes, M.L.2
  • 29
    • 0020962424 scopus 로고
    • Multiple sclerosis. Distribution of T cells, T cell subsets and Ia-positive macrophages in lesions of different ages
    • DOI 10.1016/0165-5728(83)90036-X
    • U. Traugott, E.L. Reinherz, and C.S. Raine Multiple sclerosis. Distribution of T cells, T cell subsets and Ia-positive macrophages in lesions of different ages J. Neuroimmunol. 4 1983 201 221 (Pubitemid 13075816)
    • (1983) Journal of Neuroimmunology , vol.4 , Issue.3 , pp. 201-221
    • Traugott, U.1    Reinherz, E.L.2    Raine, C.S.3
  • 31
    • 66549130329 scopus 로고    scopus 로고
    • The relation between inflammation and neurodegeneration in multiple sclerosis brains
    • J.M. Frischer The relation between inflammation and neurodegeneration in multiple sclerosis brains Brain 132 2009 1175 1189
    • (2009) Brain , vol.132 , pp. 1175-1189
    • Frischer, J.M.1
  • 32
    • 0022459287 scopus 로고
    • Immunohistochemical analysis of the cellular infiltrate in multiple sclerosis lesions
    • S.L. Hauser, A.K. Bhan, F. Gilles, M. Kemp, C. Kerr, and H.L. Weiner Immunohistochemical analysis of the cellular infiltrate in multiple sclerosis lesions Ann. Neurol. 19 1986 578 587 (Pubitemid 16085192)
    • (1986) Annals of Neurology , vol.19 , Issue.6 , pp. 578-587
    • Hauser, S.L.1    Bhan, A.K.2    Gilles, F.3
  • 34
    • 0036602982 scopus 로고    scopus 로고
    • Cytotoxic T lymphocytes in autoimmune and degenerative CNS diseases
    • DOI 10.1016/S0166-2236(02)02154-9, PII S0166223602021549
    • H. Neumann, I.M. Medana, J. Bauer, and H. Lassmann Cytotoxic T lymphocytes in autoimmune and degenerative CNS diseases Trends Neurosci. 25 2002 313 319 (Pubitemid 34667013)
    • (2002) Trends in Neurosciences , vol.25 , Issue.6 , pp. 313-319
    • Neumann, H.1    Medana, I.M.2    Bauer, J.3    Lassmann, H.4
  • 35
    • 0034026912 scopus 로고    scopus 로고
    • Acute axonal injury in multiple sclerosis. Correlation with demyelination and inflammation
    • A. Bitsch, J. Schuchardt, S. Bunkowski, T. Kuhlmann, and W. Bruck Acute axonal injury in multiple sclerosis. Correlation with demyelination and inflammation Brain 123 Pt 6 2000 1174 1183 (Pubitemid 30312109)
    • (2000) Brain , vol.123 , Issue.6 , pp. 1174-1183
    • Bitsch, A.1    Schuchardt, J.2    Bunkowski, S.3    Kuhlmann, T.4    Bruck, W.5
  • 36
    • 0036788406 scopus 로고    scopus 로고
    • Acute axonal damage in multiple sclerosis is most extensive in early disease stages and decreases over time
    • T. Kuhlmann, G. Lingfeld, A. Bitsch, J. Schuchardt, and W. Bruck Acute axonal damage in multiple sclerosis is most extensive in early disease stages and decreases over time Brain 125 2002 2202 2212
    • (2002) Brain , vol.125 , pp. 2202-2212
    • Kuhlmann, T.1    Lingfeld, G.2    Bitsch, A.3    Schuchardt, J.4    Bruck, W.5
  • 39
    • 0031048921 scopus 로고    scopus 로고
    • + cytotoxic T lymphocytes restricted by HLA-A3: Evidence for cross-reactivity with an environmental microorganism
    • DOI 10.1016/S0165-5728(96)00161-0, PII S0165572896001610
    • K. Honma, K.C. Parker, K.G. Becker, H.F. McFarland, J.E. Coligan, and W.E. Biddison Identification of an epitope derived from human proteolipid protein that can induce autoreactive CD8+ cytotoxic T lymphocytes restricted by HLA-A3: evidence for cross-reactivity with an environmental microorganism J. Neuroimmunol. 73 1997 7 14 (Pubitemid 27105264)
    • (1997) Journal of Neuroimmunology , vol.73 , Issue.1-2 , pp. 7-14
    • Honma, K.1    Parker, K.C.2    Becker, K.G.3    McFarland, H.F.4    Coligan, J.E.5    Biddison, W.E.6
  • 40
    • 0031573209 scopus 로고    scopus 로고
    • Autoantigen Recognition by Human CD8 T Cell Clones: Enhanced Agonist Response Induced by Altered Peptide Ligands
    • A. Dressel, J.L. Chin, A. Sette, R. Gausling, P. Hollsberg, and D.A. Hafler Autoantigen recognition by human CD8 T cell clones: enhanced agonist response induced by altered peptide ligands J. Immunol. 159 1997 4943 4951 (Pubitemid 127471031)
    • (1997) Journal of Immunology , vol.159 , Issue.10 , pp. 4943-4951
    • Dressel, A.1    Chin, J.L.2    Sette, A.3    Gausling, R.4    Hollsberg, P.5    Hafler, D.A.6
  • 43
    • 50549088349 scopus 로고    scopus 로고
    • Blood CD8+ T cell responses against myelin determinants in multiple sclerosis and healthy individuals
    • L. Berthelot Blood CD8+ T cell responses against myelin determinants in multiple sclerosis and healthy individuals Eur. J. Immunol. 38 2008 1889 1899
    • (2008) Eur. J. Immunol. , vol.38 , pp. 1889-1899
    • Berthelot, L.1
  • 44
    • 0032521030 scopus 로고    scopus 로고
    • MHC class I-restricted lysis of human oligodendrocytes by myelin basic protein peptide-specific CD8 T lymphocytes
    • A. Jurewicz, W.E. Biddison, and J.P. Antel MHC class I-restricted lysis of human oligodendrocytes by myelin basic protein peptide-specific CD8 T lymphocytes J. Immunol. 160 1998 3056 3059 (Pubitemid 28136763)
    • (1998) Journal of Immunology , vol.160 , Issue.6 , pp. 3056-3059
    • Jurewicz, A.1    Biddison, W.E.2    Antel, J.P.3
  • 45
    • 38749143286 scopus 로고    scopus 로고
    • Interleukin-17 production in central nervous system-infiltrating T cells and glial cells is associated with active disease in multiple sclerosis
    • DOI 10.2353/ajpath.2008.070690
    • J.S. Tzartos, M.A. Friese, M.J. Craner, J. Palace, J. Newcombe, M.M. Esiri, and L. Fugger Interleukin-17 production in central nervous system-infiltrating T cells and glial cells is associated with active disease in multiple sclerosis Am. J. Pathol. 172 2008 146 155 (Pubitemid 351186376)
    • (2008) American Journal of Pathology , vol.172 , Issue.1 , pp. 146-155
    • Tzartos, J.S.1    Friese, M.A.2    Craner, M.J.3    Palace, J.4    Newcombe, J.5    Esiri, M.M.6    Fugger, L.7
  • 46
    • 79551700235 scopus 로고    scopus 로고
    • CD161(high)CD8+T cells bear pathogenetic potential in multiple sclerosis
    • V. Annibali CD161(high)CD8+T cells bear pathogenetic potential in multiple sclerosis Brain 134 2011 542 554
    • (2011) Brain , vol.134 , pp. 542-554
    • Annibali, V.1
  • 47
    • 65249175159 scopus 로고    scopus 로고
    • C-C chemokine receptor 6-regulated entry of TH-17 cells into the CNS through the choroid plexus is required for the initiation of EAE
    • A. Reboldi C-C chemokine receptor 6-regulated entry of TH-17 cells into the CNS through the choroid plexus is required for the initiation of EAE Nat. Immunol. 10 2009 514 523
    • (2009) Nat. Immunol. , vol.10 , pp. 514-523
    • Reboldi, A.1
  • 48
    • 33947190428 scopus 로고    scopus 로고
    • CSF enrichment of highly differentiated CD8+ T cells in early multiple sclerosis
    • DOI 10.1016/j.clim.2006.11.004, PII S1521661606009466
    • S. Jilek, M. Schluep, A.O. Rossetti, L. Guignard, G. Le Goff, G. Pantaleo, and R.A. Du Pasquier CSF enrichment of highly differentiated CD8+ T cells in early multiple sclerosis Clin. Immunol. 123 2007 105 113 (Pubitemid 46401506)
    • (2007) Clinical Immunology , vol.123 , Issue.1 , pp. 105-113
    • Jilek, S.1    Schluep, M.2    Rossetti, A.O.3    Guignard, L.4    Le Goff, G.5    Pantaleo, G.6    Du Pasquier, R.A.7
  • 50
    • 24944569742 scopus 로고    scopus 로고
    • Chemokine receptor CCR7 required for T lymphocyte exit from peripheral tissues
    • DOI 10.1038/ni1238, PII N1238
    • G.F. Debes, C.N. Arnold, A.J. Young, S. Krautwald, M. Lipp, J.B. Hay, and E.C. Butcher Chemokine receptor CCR7 required for T lymphocyte exit from peripheral tissues Nat. Immunol. 6 2005 889 894 (Pubitemid 43090443)
    • (2005) Nature Immunology , vol.6 , Issue.9 , pp. 889-894
    • Debes, G.F.1    Arnold, C.N.2    Young, A.J.3    Krautwald, S.4    Lipp, M.5    Hay, J.B.6    Butcher, E.C.7
  • 51
    • 24944583626 scopus 로고    scopus 로고
    • Chemokine receptor CCR7 guides T cell exit from peripheral tissues and entry into afferent lymphatics
    • DOI 10.1038/ni1240, PII N1240
    • S.K. Bromley, S.Y. Thomas, and A.D. Luster Chemokine receptor CCR7 guides T cell exit from peripheral tissues and entry into afferent lymphatics Nat. Immunol. 6 2005 895 901 (Pubitemid 43090444)
    • (2005) Nature Immunology , vol.6 , Issue.9 , pp. 895-901
    • Bromley, S.K.1    Thomas, S.Y.2    Luster, A.D.3
  • 52
    • 27144467078 scopus 로고    scopus 로고
    • The genetics of the persistent infection and demyelinating disease caused by Theiler's virus
    • DOI 10.1146/annurev.micro.59.030804.121242
    • M. Brahic, J.F. Bureau, and T. Michiels The genetics of the persistent infection and demyelinating disease caused by Theiler's virus Annu. Rev. Microbiol. 59 2005 279 298 (Pubitemid 41507433)
    • (2005) Annual Review of Microbiology , vol.59 , pp. 279-298
    • Brahic, M.1    Bureau, J.-F.2    Michiels, T.3
  • 53
    • 63149158618 scopus 로고    scopus 로고
    • Antiviral immune responses: Triggers of or triggered by autoimmunity?
    • C. Munz, J.D. Lunemann, M.T. Getts, and S.D. Miller Antiviral immune responses: triggers of or triggered by autoimmunity? Nat. Rev. Immunol. 9 2009 246 258
    • (2009) Nat. Rev. Immunol. , vol.9 , pp. 246-258
    • Munz, C.1    Lunemann, J.D.2    Getts, M.T.3    Miller, S.D.4
  • 54
    • 0034842960 scopus 로고    scopus 로고
    • Transection of major histocompatibility complex class I-induced neurites by cytotoxic T lymphocytes
    • I. Medana, M.A. Martinic, H. Wekerle, and H. Neumann Transection of major histocompatibility complex class I-induced neurites by cytotoxic T lymphocytes Am. J. Pathol. 159 2001 809 815 (Pubitemid 32847171)
    • (2001) American Journal of Pathology , vol.159 , Issue.3 , pp. 809-815
    • Medana, I.1    Martinic, M.A.2    Wekerle, H.3    Neumann, H.4
  • 55
    • 33845645417 scopus 로고    scopus 로고
    • Granzyme B mediates neurotoxicity through a G-protein-coupled receptor
    • T. Wang Granzyme B mediates neurotoxicity through a G-protein-coupled receptor FASEB J. 20 2006 1209 1211
    • (2006) FASEB J. , vol.20 , pp. 1209-1211
    • Wang, T.1
  • 58
    • 12344280009 scopus 로고    scopus 로고
    • + T cell responses during experimental autoimmune encephalomyelitis
    • DOI 10.1002/eji.200425660
    • M.L. Ford, and B.D. Evavold Specificity, magnitude, and kinetics of MOG-specific CD8+ T cell responses during experimental autoimmune encephalomyelitis Eur. J. Immunol. 35 2005 76 85 (Pubitemid 40123854)
    • (2005) European Journal of Immunology , vol.35 , Issue.1 , pp. 76-85
    • Ford, M.L.1    Evavold, B.D.2
  • 60
    • 81755180291 scopus 로고    scopus 로고
    • Recognition of a high affinity MHC class I-restricted epitope of myelin oligodendrocyte glycoprotein by CD8+ T cells derived from autoantigen-deficient mice
    • M.D. Leech, A. Carrillo-Vico, R.S. Liblau, and S.M. Anderton Recognition of a high affinity MHC class I-restricted epitope of myelin oligodendrocyte glycoprotein by CD8+ T cells derived from autoantigen-deficient mice Front. Immunol. 2 2011 17
    • (2011) Front. Immunol. , vol.2 , pp. 17
    • Leech, M.D.1    Carrillo-Vico, A.2    Liblau, R.S.3    Anderton, S.M.4
  • 62
    • 49649091569 scopus 로고    scopus 로고
    • Cutting edge: Multiple sclerosis-like lesions induced by effector CD8 T cells recognizing a sequestered antigen on oligodendrocytes
    • A. Saxena Cutting edge: Multiple sclerosis-like lesions induced by effector CD8 T cells recognizing a sequestered antigen on oligodendrocytes J. Immunol. 181 2008 1617 1621
    • (2008) J. Immunol. , vol.181 , pp. 1617-1621
    • Saxena, A.1
  • 63
    • 50849121345 scopus 로고    scopus 로고
    • Naive CD8 T-cells initiate spontaneous autoimmunity to a sequestered model antigen of the central nervous system
    • S.Y. Na, Y. Cao, C. Toben, L. Nitschke, C. Stadelmann, R. Gold, A. Schimpl, and T. Hunig Naive CD8 T-cells initiate spontaneous autoimmunity to a sequestered model antigen of the central nervous system Brain 131 2008 2353 2365
    • (2008) Brain , vol.131 , pp. 2353-2365
    • Na, S.Y.1    Cao, Y.2    Toben, C.3    Nitschke, L.4    Stadelmann, C.5    Gold, R.6    Schimpl, A.7    Hunig, T.8
  • 65
    • 71549141283 scopus 로고    scopus 로고
    • Antigen-specific blockade of lethal CD8 T-cell mediated autoimmunity in a mouse model of multiple sclerosis
    • S.Y. Na, H. Eujen, K. Gobel, S.G. Meuth, K. Martens, H. Wiendl, and T. Hunig Antigen-specific blockade of lethal CD8 T-cell mediated autoimmunity in a mouse model of multiple sclerosis J. Immunol. 182 2009 6569 6575
    • (2009) J. Immunol. , vol.182 , pp. 6569-6575
    • Na, S.Y.1    Eujen, H.2    Gobel, K.3    Meuth, S.G.4    Martens, K.5    Wiendl, H.6    Hunig, T.7
  • 66
    • 55549104692 scopus 로고    scopus 로고
    • Opposing effects of HLA class i molecules in tuning autoreactive CD8+ T cells in multiple sclerosis
    • M.A. Friese Opposing effects of HLA class I molecules in tuning autoreactive CD8+ T cells in multiple sclerosis Nat. Med. 14 2008 1227 1235
    • (2008) Nat. Med. , vol.14 , pp. 1227-1235
    • Friese, M.A.1
  • 67
    • 38449098279 scopus 로고    scopus 로고
    • CD8 T cell responses to myelin oligodendrocyte glycoprotein-derived peptides in humanized HLA-A0201-transgenic mice
    • L.T. Mars CD8 T cell responses to myelin oligodendrocyte glycoprotein-derived peptides in humanized HLA-A0201-transgenic mice J. Immunol. 179 2007 5090 5098
    • (2007) J. Immunol. , vol.179 , pp. 5090-5098
    • Mars, L.T.1
  • 68
    • 43949105866 scopus 로고    scopus 로고
    • Regulatory T Cells and Immune Tolerance
    • DOI 10.1016/j.cell.2008.05.009, PII S0092867408006247
    • S. Sakaguchi, T. Yamaguchi, T. Nomura, and M. Ono Regulatory T cells and immune tolerance Cell 133 2008 775 787 (Pubitemid 351707693)
    • (2008) Cell , vol.133 , Issue.5 , pp. 775-787
    • Sakaguchi, S.1    Yamaguchi, T.2    Nomura, T.3    Ono, M.4
  • 70
    • 8644240281 scopus 로고    scopus 로고
    • Identification of a novel natural regulatory CD8 T-cell subset and analysis of its mechanism of regulation
    • DOI 10.1182/blood-2004-03-1214
    • E. Xystrakis, A.S. Dejean, I. Bernard, P. Druet, R. Liblau, D. Gonzalez-Dunia, and A. Saoudi Identification of a novel natural regulatory CD8 T-cell subset and analysis of its mechanism of regulation Blood 104 2004 3294 3301 (Pubitemid 39507148)
    • (2004) Blood , vol.104 , Issue.10 , pp. 3294-3301
    • Xystrakis, E.1    Dejean, A.S.2    Bernard, I.3    Druet, P.4    Liblau, R.5    Gonzalez-Dunia, D.6    Saoudi, A.7
  • 72
    • 8644249136 scopus 로고    scopus 로고
    • + regulatory T cells in the maintenance of T cell homeostasis
    • DOI 10.1084/jem.20040395
    • M. Rifa'i, Y. Kawamoto, I. Nakashima, and H. Suzuki Essential roles of CD8+CD122+ regulatory T cells in the maintenance of T cell homeostasis J. Exp. Med. 200 2004 1123 1134 (Pubitemid 39507052)
    • (2004) Journal of Experimental Medicine , vol.200 , Issue.9 , pp. 1123-1134
    • Rifa'i, M.1    Kawamoto, Y.2    Nakashima, I.3    Suzuki, H.4
  • 73
    • 34547103020 scopus 로고    scopus 로고
    • HLA-G expression defines a novel regulatory T-cell subset present in human peripheral blood and sites of inflammation
    • DOI 10.1182/blood-2006-11-057125
    • U. Feger, E. Tolosa, Y.H. Huang, A. Waschbisch, T. Biedermann, A. Melms, and H. Wiendl HLA-G expression defines a novel regulatory T-cell subset present in human peripheral blood and sites of inflammation Blood 110 2007 568 577 (Pubitemid 47105395)
    • (2007) Blood , vol.110 , Issue.2 , pp. 568-577
    • Feger, U.1    Tolosa, E.2    Huang, Y.-H.3    Waschbisch, A.4    Biedermann, T.5    Melms, A.6    Wiendl, H.7
  • 75
    • 45749145836 scopus 로고    scopus 로고
    • + regulatory T cells recognize activated T cells via conventional MHC class I - αβTCR interaction and become IL-10-producing active regulatory cells
    • DOI 10.1093/intimm/dxn052
    • M. Rifa'i, Z. Shi, S.Y. Zhang, Y.H. Lee, H. Shiku, K. Isobe, and H. Suzuki CD8+CD122+ regulatory T cells recognize activated T cells via conventional MHC class I-alphabetaTCR interaction and become IL-10-producing active regulatory cells Int. Immunol. 20 2008 937 947 (Pubitemid 351865868)
    • (2008) International Immunology , vol.20 , Issue.7 , pp. 937-947
    • Rifa'i, M.1    Shi, Z.2    Zhang, S.-Y.3    Lee, Y.H.4    Shiku, H.5    Isobe, K.-I.6    Suzuki, H.7
  • 78
    • 79951804510 scopus 로고    scopus 로고
    • CD8(+) Foxp3(+) T cells share developmental and phenotypic features with classical CD4(+) Foxp3(+) regulatory T cells but lack potent suppressive activity
    • C.T. Mayer, S. Floess, A.M. Baru, K. Lahl, J. Huehn, and T. Sparwasser CD8(+) Foxp3(+) T cells share developmental and phenotypic features with classical CD4(+) Foxp3(+) regulatory T cells but lack potent suppressive activity Eur. J. Immunol. 41 2011 716 725
    • (2011) Eur. J. Immunol. , vol.41 , pp. 716-725
    • Mayer, C.T.1    Floess, S.2    Baru, A.M.3    Lahl, K.4    Huehn, J.5    Sparwasser, T.6
  • 79
    • 33845748319 scopus 로고    scopus 로고
    • - Regulatory T Lymphocytes Prevent Experimental Inflammatory Bowel Disease in Mice
    • DOI 10.1053/j.gastro.2006.09.008, PII S0016508506020026
    • I. Menager-Marcq, C. Pomie, P. Romagnoli, and J.P. Van Meerwijk CD8+CD28- regulatory T lymphocytes prevent experimental inflammatory bowel disease in mice Gastroenterology 131 2006 1775 1785 (Pubitemid 44970462)
    • (2006) Gastroenterology , vol.131 , Issue.6 , pp. 1775-1785
    • MEnager-Marcq, I.1    PomiE, C.2    Romagnoli, P.3    Van Meerwijk, J.P.M.4
  • 81
    • 18644366689 scopus 로고    scopus 로고
    • License to heal: Bidirectional interaction of antigen-specific regulatory T cells and tolerogenic APC
    • G. Vlad, R. Cortesini, and N. Suciu-Foca License to heal: bidirectional interaction of antigen-specific regulatory T cells and tolerogenic APC J. Immunol. 174 2005 5907 5914 (Pubitemid 40663774)
    • (2005) Journal of Immunology , vol.174 , Issue.10 , pp. 5907-5914
    • Vlad, G.1    Cortesini, R.2    Suciu-Foca, N.3
  • 82
    • 77953635469 scopus 로고    scopus 로고
    • Control of T cell reactivation by regulatory Qa-1-restricted CD8+ T cells
    • A. Varthaman Control of T cell reactivation by regulatory Qa-1-restricted CD8+ T cells J. Immunol. 184 2010 6585 6591
    • (2010) J. Immunol. , vol.184 , pp. 6585-6591
    • Varthaman, A.1
  • 83
    • 0036338136 scopus 로고    scopus 로고
    • Positive selection of a Qa-1-restricted T cell receptor with specificity for insulin
    • DOI 10.1016/S1074-7613(02)00343-6
    • B.A. Sullivan, P. Kraj, D.A. Weber, L. Ignatowicz, and P.E. Jensen Positive selection of a Qa-1-restricted T cell receptor with specificity for insulin Immunity 17 2002 95 105 (Pubitemid 34874622)
    • (2002) Immunity , vol.17 , Issue.1 , pp. 95-105
    • SulliVan, B.A.1    Kraj, P.2    Weber, D.A.3    Ignatowicz, L.4    Jensen, P.E.5
  • 84
    • 77956895738 scopus 로고    scopus 로고
    • Inhibition of follicular T-helper cells by CD8(+) regulatory T cells is essential for self tolerance
    • H.J. Kim, B. Verbinnen, X. Tang, L. Lu, and H. Cantor Inhibition of follicular T-helper cells by CD8(+) regulatory T cells is essential for self tolerance Nature 467 2010 328 332
    • (2010) Nature , vol.467 , pp. 328-332
    • Kim, H.J.1    Verbinnen, B.2    Tang, X.3    Lu, L.4    Cantor, H.5
  • 87
    • 0026647293 scopus 로고
    • Role of CD8+ T cells in murine experimental allergic encephalomyelitis
    • H. Jiang, S.I. Zhang, and B. Pernis Role of CD8+ T cells in murine experimental allergic encephalomyelitis Science 256 1992 1213 1215
    • (1992) Science , vol.256 , pp. 1213-1215
    • Jiang, H.1    Zhang, S.I.2    Pernis, B.3
  • 89
    • 79959623842 scopus 로고    scopus 로고
    • Physiological induction of regulatory Qa-1-restricted CD8+ T cells triggered by endogenous CD4+ T cell responses
    • A. Varthaman Physiological induction of regulatory Qa-1-restricted CD8+ T cells triggered by endogenous CD4+ T cell responses PLoS ONE 6 2011 e21628
    • (2011) PLoS ONE , vol.6 , pp. 21628
    • Varthaman, A.1
  • 90
    • 40449120318 scopus 로고    scopus 로고
    • Essential role of CD8+CD122+ regulatory T cells in the recovery from experimental autoimmune encephalomyelitis
    • Y.H. Lee, Y. Ishida, M. Rifa'i, Z. Shi, K. Isobe, and H. Suzuki Essential role of CD8+CD122+ regulatory T cells in the recovery from experimental autoimmune encephalomyelitis J. Immunol. 180 2008 825 832
    • (2008) J. Immunol. , vol.180 , pp. 825-832
    • Lee, Y.H.1    Ishida, Y.2    Rifa'I, M.3    Shi, Z.4    Isobe, K.5    Suzuki, H.6
  • 91
    • 0022995760 scopus 로고
    • + cell lines from patientss with progressive multiple sclerosis
    • J. Antel, M. Bania, A. Noronha, and S. Neely Defective suppressor cell function mediated by T8+ cell lines from patients with progressive multiple sclerosis J. Immunol. 137 1986 3436 3439 (Pubitemid 17193296)
    • (1986) Journal of Immunology , vol.137 , Issue.11 , pp. 3436-3439
    • Antel, J.1    Bania, M.2    Noronha, A.3    Neely, S.4
  • 92
    • 0022446678 scopus 로고
    • Suppressor and cytolytic cell function in multiple sclerosis. Effects of cyclosporine A and interleukin 2
    • M.B. Bania, J.P. Antel, A.T. Reder, M.K. Nicholas, and B.G. Arnason Suppressor and cytolytic cell function in multiple sclerosis. Effects of cyclosporine A and interleukin 2 J. Clin. Invest. 78 1986 582 586 (Pubitemid 16074098)
    • (1986) Journal of Clinical Investigation , vol.78 , Issue.2 , pp. 582-586
    • Bania, M.B.1    Antel, J.P.2    ReDer, A.T.3
  • 93
    • 48949116961 scopus 로고    scopus 로고
    • The role of regulatory T cells in multiple sclerosis
    • DOI 10.1038/ncpneuro0832, PII NCPNEURO0832
    • A.L. Zozulya, and H. Wiendl The role of regulatory T cells in multiple sclerosis Nat. Clin. Pract. Neurol. 4 2008 384 398 (Pubitemid 352003290)
    • (2008) Nature Clinical Practice Neurology , vol.4 , Issue.7 , pp. 384-398
    • Zozulya, A.L.1    Wiendl, H.2
  • 94
    • 41949135382 scopus 로고    scopus 로고
    • Isolation and characterization of CD8+ regulatory T cells in multiple sclerosis
    • J. Correale, and A. Villa Isolation and characterization of CD8+ regulatory T cells in multiple sclerosis J. Neuroimmunol. 195 2008 121 134
    • (2008) J. Neuroimmunol. , vol.195 , pp. 121-134
    • Correale, J.1    Villa, A.2
  • 95
    • 72649090947 scopus 로고    scopus 로고
    • Glatiramer acetate for the treatment of multiple sclerosis: Evidence for a dual anti-inflammatory and neuroprotective role
    • R. Liblau Glatiramer acetate for the treatment of multiple sclerosis: evidence for a dual anti-inflammatory and neuroprotective role J. Neurol. Sci. 287 Suppl. 1 2009 S17 S23
    • (2009) J. Neurol. Sci. , vol.287 , Issue.SUPPL. 1
    • Liblau, R.1
  • 98
    • 34347352225 scopus 로고    scopus 로고
    • Postpartum-activation of multiple sclerosis is associated with down-regulation of tolerogenic HLA-G
    • DOI 10.1016/j.jneuroim.2007.05.008, PII S0165572807001634
    • L. Airas, T. Nikula, Y.H. Huang, R. Lahesmaa, and H. Wiendl Postpartum-activation of multiple sclerosis is associated with down-regulation of tolerogenic HLA-G J. Neuroimmunol. 187 2007 205 211 (Pubitemid 47008932)
    • (2007) Journal of Neuroimmunology , vol.187 , Issue.1-2 , pp. 205-211
    • Airas, L.1    Nikula, T.2    Huang, Y.-H.3    Lahesmaa, R.4    Wiendl, H.5


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.