Postpartum-activation of multiple sclerosis is associated with down-regulation of tolerogenic HLA-G

Journal of Neuroimmunology

Volumn 187, Issue 1-2, 2007, Pages 205-211

  Airas, Laura ^a   Nikula, Tuomas ^b   Huang, Yu Hwa ^c   Lahesmaa, Riitta ^b   Wiendl, Heinz ^c  

^a UNIVERSITY OF TURKU   (Finland)

^b UNIVERSITY OF TURKU   (Finland)

^c UNIVERSITY OF WÜRZBURG   (Germany)

Author keywords

HLA G; Microarray; Multiple sclerosis; Postpartum activation; Pregnancy

Indexed keywords

HLA G ANTIGEN;

ADULT; ARTICLE; CLINICAL ARTICLE; COMPARATIVE STUDY; CONTROLLED STUDY; DISEASE ACTIVITY; DOWN REGULATION; ENZYME LINKED IMMUNOSORBENT ASSAY; FEMALE; FLOW CYTOMETRY; GENE EXPRESSION; HISTOCOMPATIBILITY; HUMAN; IMMUNOREGULATION; MICROARRAY ANALYSIS; MULTIPLE SCLEROSIS; PERIPHERAL BLOOD MONONUCLEAR CELL; PREGNANCY; PRIORITY JOURNAL; PUERPERIUM; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION;

ADULT; ANALYSIS OF VARIANCE; DOWN-REGULATION; ENZYME-LINKED IMMUNOSORBENT ASSAY; FEMALE; FLOW CYTOMETRY; GENE EXPRESSION PROFILING; HISTOCOMPATIBILITY ANTIGENS CLASS I; HLA ANTIGENS; HUMANS; IMMUNE TOLERANCE; MULTIPLE SCLEROSIS; OLIGONUCLEOTIDE ARRAY SEQUENCE ANALYSIS; POSTPARTUM PERIOD; PREGNANCY; SEVERITY OF ILLNESS INDEX;

EID: 34347352225     PISSN: 01655728     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jneuroim.2007.05.008     Document Type: Article

References (31)

1. Achiron A., Gurevich M., Friedman N., Kaminski N., and Mandel M. Blood transcriptional signatures of multiple sclerosis: unique gene expression of disease activity. Ann. Neurol. 55 (2004) 410-417
2. Airla N., Luomala M., Elovaara I., Kettunen E., Knuutila S., and Lehtimaki T. Suppression of immune system genes by methylprednisolone in exacerbations of multiple sclerosis. Preliminary results. J. Neurol. 251 (2004) 1215-1219
3. Baechler E.C., Batliwalla F.M., Karypis G., Gaffney P.M., Moser K., Ortmann W.A., Espe K.J., Balasubramanian S., Hughes K.M., Chan J.P., Begovich A., Chang S.Y., Gregersen P.K., and Behrens T.W. Expression levels for many genes in human peripheral blood cells are highly sensitive to ex vivo incubation. Genes Immun. 5 (2004) 347-353
4. Bebo Jr. B.F., and Dveksler G.S. Evidence that pregnancy specific glycoproteins regulate T-Cell function and inflammatory autoimmune disease during pregnancy. Curr. Drug Targets Inflamm. Allergy 4 (2005) 231-237
5. Bomprezzi R., Ringner M., Kim S., Bittner M.L., Khan J., Chen Y., Elkahloun A., Yu A., Bielekova B., Meltzer P.S., Martin R., McFarland H.F., and Trent J.M. Gene expression profile in multiple sclerosis patients and healthy controls: identifying pathways relevant to disease. Hum. Mol. Genet. 12 (2003) 2191-2199
6. Carosella E.D., Moreau P., Aractingi S., and Rouas-Freiss N. HLA-G: a shield against inflammatory aggression. Trends Immunol. 22 (2001) 553-555
7. Chaouat G., Ledee-Bataille N., Dubanchet S., Zourbas S., Sandra O., and Martal J. Reproductive immunology 2003: reassessing the Th1/Th2 paradigm?. Immunol. Lett. 92 (2004) 207-214
8. Clark D.A. Tolerance signaling molecules. Chem. Immunol. Allergy 89 (2005) 36-48
9. Confavreux C., Hutchinson M., Hours M.M., Cortinovis-Tourniaire P., and Moreau T. Rate of pregnancy-related relapse in multiple sclerosis. Pregnancy in Multiple Sclerosis Group. N. Engl. J. Med. 339 (1998) 285-291
10. Fainardi E., Rizzo R., Melchiorri L., Vaghi L., Castellazzi M., Marzola A., Govoni V., Paolino E., Tola M.R., Granieri E., and Baricordi O.R. Presence of detectable levels of soluble HLA-G molecules in CSF of relapsing-remitting multiple sclerosis: relationship with CSF soluble HLA-I and IL-10 concentrations and MRI findings. J. Neuroimmunol. 142 (2003) 149-158
11. Feger, U., Tolosa, E., Huang, Y.H.,Waschbisch, A., Biedermann, T., Melms, A., Wiendl, H., in press. HLA-G expression defines a novel regulatory T cell subset present in human peripheral blood and sites of inflammation. Blood. [Electronic publication ahead of print, Mar 19]
12. Hunt J.S., Petroff M.G., McIntire R.H., and Ober C. HLA-G and immune tolerance in pregnancy. FASEB J. 19 (2005) 681-693
13. Irony-Tur-Sinai M., Grigoriadis N., Lourbopoulos A., Pinto-Maaravi F., Abramsky O., and Brenner T. Amelioration of autoimmune neuroinflammation by recombinant human alpha-fetoprotein. Exp. Neurol. 198 (2006) 136-144
14. Kim S., Liva S.M., Dalal M.A., Verity M.A., and Voskuhl R.R. Estriol ameliorates autoimmune demyelinating disease: implications for multiple sclerosis. Neurology 52 (1999) 1230-1238
15. Lafon M., Prehaud C., Megret F., Lafage M., Mouillot G., Roa M., Moreau P., Rouas-Freiss N., and Carosella E.D. Modulation of HLA-G expression in human neural cells after neurotropic viral infections. J. Virol. 79 (2005) 15226-15237
16. LeMaoult J., Rouas-Freiss N., and Carosella E.D. Immuno-tolerogenic functions of HLA-G: relevance in transplantation and oncology. Autoimmun. Rev. 4 (2005) 503-509
17. Mitsdoerffer M., Schreiner B., Kieseier B.C., Neuhaus O., Dichgans J., Hartung H.P., Weller M., and Wiendl H. Monocyte-derived HLA-G acts as a strong inhibitor of autologous CD4 T cell activation and is upregulated by interferon-beta in vitro and in vivo: rationale for the therapy of multiple sclerosis. J. Neuroimmunol. 159 (2005) 155-164
18. Nikula T., West A., Katajamaa M., Lonnberg T., Sara R., Aittokallio T., Nevalainen O.S., and Lahesmaa R. A human ImmunoChip cDNA microarray provides a comprehensive tool to study immune responses. J. Immunol. Methods 303 (2005) 122-134
19. Polanczyk M.J., Jones R.E., Subramanian S., Afentoulis M., Rich C., Zakroczymski M., Cooke P., Vandenbark A.A., and Offner H. T lymphocytes do not directly mediate the protective effect of estrogen on experimental autoimmune encephalomyelitis. Am. J. Pathol. 165 (2004) 2069-2077
20. Polanczyk M.J., Hopke C., Huan J., Vandenbark A.A., and Offner H. Enhanced FoxP3 expression and Treg cell function in pregnant and estrogen-treated mice. J. Neuroimmunol. 170 (2005) 85-92
21. Rainen L., Oelmueller U., Jurgensen S., Wyrich R., Ballas C., Schram J., Herdman C., Bankaitis-Davis D., Nicholls N., Trollinger D., and Tryon V. Stabilization of mRNA expression in whole blood samples. Clin. Chem. 48 (2002) 1883-1890
22. Ramanathan M., Weinstock-Guttman B., Nguyen L.T., Badgett D., Miller C., Patrick K., Brownscheidle C., and Jacobs L. In vivo gene expression revealed by cDNA arrays: the pattern in relapsing-remitting multiple sclerosis patients compared with normal subjects. J. Neuroimmunol. 116 (2001) 213-219
23. Romualdi C., Vitulo N., Del Favero M., and Lanfranchi G. MIDAW: a web tool for statistical analysis of microarray data. Nucleic Acids Res. 33 (2005) W644-W649
24. Sanchez-Ramon S., Navarro A.J., Aristimuno C., Rodriguez-Mahou M., Bellon J.M., Fernandez-Cruz E., and de Andres C. Pregnancy-induced expansion of regulatory T-lymphocytes may mediate protection to multiple sclerosis activity. Immunol. Lett. 96 (2005) 195-201
25. Sicotte N.L., Liva S.M., Klutch R., Pfeiffer P., Bouvier S., Odesa S., Wu T.C., and Voskuhl R.R. Treatment of multiple sclerosis with the pregnancy hormone estriol. Ann. Neurol. 52 (2002) 421-428
26. Sturzebecher S., Wandinger K.P., Rosenwald A., Sathyamoorthy M., Tzou A., Mattar P., Frank J.A., Staudt L., Martin R., and McFarland H.F. Expression profiling identifies responder and non-responder phenotypes to interferon-beta in multiple sclerosis. Brain 126 (2003) 1419-1429
27. Wegmann T.G., Lin H., Guilbert L., and Mosmann T.R. Bidirectional cytokine interactions in the maternal-fetal relationship: is successful pregnancy a TH2 phenomenon?. Immunol. Today 14 (1993) 353-356
28. Weinstock-Guttman B., Badgett D., Patrick K., Hartrich L., Santos R., Hall D., Baier M., Feichter J., and Ramanathan M. Genomic effects of IFN-beta in multiple sclerosis patients. J. Immunol. 171 (2003) 2694-2702
29. Wiendl H., Mitsdoerffer M., and Weller M. Express and protect yourself: the potential role of HLA-G on muscle cells and in inflammatory myopathies. Hum. Immunol. 64 (2003) 1050-1056
30. Wiendl H., Feger U., Mittelbronn M., Jack C., Schreiner B., Stadelmann C., Antel J., Brueck W., Meyermann R., Bar-Or A., Kieseier B.C., and Weller M. Expression of the immune-tolerogenic major histocompatibility molecule HLA-G in multiple sclerosis: implications for CNS immunity. Brain 128 (2005) 2689-2704
31. Yang Y.H., Dudoit S., Luu P., Lin D.M., Peng V., Ngai J., and Speed T.P. Normalization for cDNA microarray data: a robust composite method addressing single and multiple slide systematic variation. Nucleic Acids Res. 30 (2002) e15