Four generations of transition-state analogues for human purine nucleoside phosphorylase

Proceedings of the National Academy of Sciences of the United States of America

Volumn 107, Issue 11, 2010, Pages 4805-4812

  Ho, Meng Chiao ^a   Shi, Wuxian ^a,c   Rinaldo Matthis, Agnes ^a,d   Tyler, Peter C ^b   Evans, Gary B ^b   Clinch, Keith ^b   Almo, Steven C ^a   Schramm, Vern L ^a  

^a ALBERT EINSTEIN COLLEGE OF MEDICINE   (United States)

^b CALLAGHAN INNOVATION   (New Zealand)

^c BROOKHAVEN NATIONAL LABORATORY   (United States)

^d KAROLINSKA INSTITUTE   (Sweden)

Author keywords

Enzyme structure; Immucillins; Inhibitor design; T cells disorders; Tight binding

Indexed keywords

AMINOALCOHOL; CARBENE; CARBON; FORODESINE; PURINE NUCLEOSIDE PHOSPHORYLASE;

ARTICLE; CHEMICAL INTERACTION; CRYSTAL STRUCTURE; ENZYME BINDING; PRIORITY JOURNAL; PROTEIN INTERACTION; PROTEIN STRUCTURE; THERMODYNAMICS;

ANIMALS; CATALYTIC DOMAIN; CATTLE; ENZYME INHIBITORS; HUMANS; MODELS, MOLECULAR; PROTEIN CONFORMATION; PURINE NUCLEOSIDES; PURINE-NUCLEOSIDE PHOSPHORYLASE; PYRIMIDINONES; PYRROLIDINES; THERMODYNAMICS;

EID: 77950425363     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.0913439107     Document Type: Article

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