Central mechanisms involved in the orexigenic actions of ghrelin

Peptides

Volumn 32, Issue 11, 2011, Pages 2248-2255

  Andrews, Zane B ^a  

^a MONASH UNIVERSITY   (Australia)

Author keywords

AgRP; AMPK; CaMKK; CPT1; Ghrelin; Ghrelin resistance; Intracellular; NPY; UCP

Indexed keywords

ACETYL COENZYME A CARBOXYLASE; APPETITE STIMULANT; CARNITINE PALMITOYLTRANSFERASE I; GHRELIN; GROWTH HORMONE SECRETAGOGUE RECEPTOR; MALONYL COENZYME A DECARBOXYLASE; MITOGEN ACTIVATED PROTEIN KINASE; REACTIVE OXYGEN METABOLITE;

BODY WEIGHT; FOOD INTAKE; GENE EXPRESSION; HYPOTHALAMUS; IMMUNOREACTIVITY; MITOCHONDRION; NERVE CELL; NONHUMAN; OBESITY; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; REVIEW; SIGNAL TRANSDUCTION;

ACYLTRANSFERASES; AGOUTI-RELATED PROTEIN; ANIMALS; APPETITE REGULATION; CALCIUM; DIET, HIGH-FAT; EATING; ENERGY METABOLISM; FASTING; GENE EXPRESSION; GHRELIN; HUMANS; HYPOTHALAMUS; MICE; MICE, KNOCKOUT; NEURONS; NEUROPEPTIDE Y; RECEPTORS, GHRELIN; SIGNAL TRANSDUCTION; STOMACH;

MUS;

EID: 81755172024     PISSN: 01969781     EISSN: 18735169     Source Type: Journal    
DOI: 10.1016/j.peptides.2011.05.014     Document Type: Review

References (72)

1. A. Abizaid, Z.W. Liu, Z.B. Andrews, M. Shanabrough, E. Borok, and J.D. Elsworth Ghrelin modulates the activity and synaptic input organization of midbrain dopamine neurons while promoting appetite J Clin Invest 116 2006 3229 3239
2. K.A. Anderson, T.J. Ribar, F. Lin, P.K. Noeldner, M.F. Green, and M.J. Muehlbauer Hypothalamic CaMKK2 contributes to the regulation of energy balance Cell Metab 7 2008 377 388
3. U. Andersson, K. Filipsson, C.R. Abbott, A. Woods, K. Smith, and S.R. Bloom AMP-activated protein kinase plays a role in the control of food intake J Biol Chem 279 2004 12005 12008
4. Z.B. Andrews The extra-hypothalamic actions of ghrelin on neuronal function Trends Neurosci 34 2011 31 40
5. Z.B. Andrews, S. Diano, and T.L. Horvath Mitochondrial uncoupling proteins in the CNS: in support of function and survival Nat Rev Neurosci 6 2005 829 840
6. Z.B. Andrews, D. Erion, R. Beiler, Z.W. Liu, A. Abizaid, and J. Zigman Ghrelin promotes and protects nigrostriatal dopamine function via a UCP2-dependent mitochondrial mechanism J Neurosci 29 2009 14057 14065
7. Z.B. Andrews, Z.W. Liu, N. Walllingford, D.M. Erion, E. Borok, and J.M. Friedman UCP2 mediates ghrelin's action on NPY/AgRP neurons by lowering free radicals Nature 454 2008 846 851
8. W.A. Banks The blood-brain barrier as a cause of obesity Curr Pharm Des 14 2008 1606 1614
9. S.G. Bouret, J.N. Gorski, C.M. Patterson, S. Chen, B.E. Levin, and R.B. Simerly Hypothalamic neural projections are permanently disrupted in diet-induced obese rats Cell Metab 7 2008 179 185
10. D.I. Briggs, and Z.B. Andrews Metabolic status regulates ghrelin function on energy homeostasis Neuroendocrinology 93 2011 48 57
11. D.I. Briggs, and Z.B. Andrews A recent update on the role of ghrelin in glucose homeostasis Curr Diab Rev 2011
12. D.I. Briggs, P.J. Enriori, M.B. Lemus, M.A. Cowley, and Z.B. Andrews Diet-induced obesity causes ghrelin resistance in arcuate NPY/AgRP neurons Endocrinology 151 2010 4745 4755
13. D.I. Briggs, M.B. Lemus, E. Kua, and Z.B. Andrews Diet-induced obesity attenuates fasting-induced hyperphagia J Neuroendocrinol 2011
14. H.Y. Chen, M.E. Trumbauer, A.S. Chen, D.T. Weingarth, J.R. Adams, and E.G. Frazier Orexigenic action of peripheral ghrelin is mediated by neuropeptide Y and agouti-related protein Endocrinology 145 2004 2607 2612
15. M. Claret, M.A. Smith, R.L. Batterham, C. Selman, A.I. Choudhury, and L.G. Fryer AMPK is essential for energy homeostasis regulation and glucose sensing by POMC and AgRP neurons J Clin Invest 117 2007 2325 2336
16. S.P. Collins, J.L. Reoma, D.M. Gamm, and M.D. Uhler LKB1, a novel serine/threonine protein kinase and potential tumour suppressor, is phosphorylated by cAMP-dependent protein kinase (PKA) and prenylated in vivo Biochem J 345 Pt 3 2000 673 680
17. M.A. Cowley, R.G. Smith, S. Diano, M. Tschop, N. Pronchuk, and K.L. Grove The distribution and mechanism of action of ghrelin in the CNS demonstrates a novel hypothalamic circuit regulating energy homeostasis Neuron 37 2003 649 661
18. J.C. Erickson, G. Hollopeter, and R.D. Palmiter Attenuation of the obesity syndrome of ob/ob mice by the loss of neuropeptide Y Science 274 1996 1704 1707
19. X.F. Gao, W. Chen, X.P. Kong, A.M. Xu, Z.G. Wang, and G. Sweeney Enhanced susceptibility of Cpt1c knockout mice to glucose intolerance induced by a high-fat diet involves elevated hepatic gluconeogenesis and decreased skeletal muscle glucose uptake Diabetologia 52 2009 912 920
20. E. Gropp, M. Shanabrough, E. Borok, A.W. Xu, R. Janoschek, and T. Buch Agouti-related peptide-expressing neurons are mandatory for feeding Nat Neurosci 8 2005 1289 1291
21. J.A. Gutierrez, P.J. Solenberg, D.R. Perkins, J.A. Willency, M.D. Knierman, and Z. Jin Ghrelin octanoylation mediated by an orphan lipid transferase Proc Natl Acad Sci U S A 105 2008 6320 6325
22. A.K. Hewson, and S.L. Dickson Systemic administration of ghrelin induces Fos and Egr-1 proteins in the hypothalamic arcuate nucleus of fasted and fed rats J Neuroendocrinol 12 2000 1047 1049
23. B. Holst, A. Cygankiewicz, T.H. Jensen, M. Ankersen, and T.W. Schwartz High constitutive signaling of the ghrelin receptor - identification of a potent inverse agonist Mol Endocrinol 17 2003 2201 2210
24. H. Jiang, L. Betancourt, and R.G. Smith Ghrelin amplifies dopamine signaling by cross talk involving formation of growth hormone secretagogue receptor/dopamine receptor subtype 1 heterodimers Mol Endocrinol 20 2006 1772 1785
25. J. Kamegai, H. Tamura, T. Shimizu, S. Ishii, H. Sugihara, and I. Wakabayashi Central effect of ghrelin, an endogenous growth hormone secretagogue, on hypothalamic peptide gene expression Endocrinology 141 2000 4797 4800
26. J. Kamegai, H. Tamura, T. Shimizu, S. Ishii, H. Sugihara, and I. Wakabayashi Chronic central infusion of ghrelin increases hypothalamic neuropeptide Y and Agouti-related protein mRNA levels and body weight in rats Diabetes 50 2001 2438 2443
27. H. Kirchner, J.A. Gutierrez, P.J. Solenberg, P.T. Pfluger, T.A. Czyzyk, and J.A. Willency GOAT links dietary lipids with the endocrine control of energy balance Nat Med 15 2009 741 745
28. D. Kohno, H.Z. Gao, S. Muroya, S. Kikuyama, and T. Yada Ghrelin directly interacts with neuropeptide-Y-containing neurons in the rat arcuate nucleus: Ca2+ signaling via protein kinase A and N-type channel-dependent mechanisms and cross-talk with leptin and orexin Diabetes 52 2003 948 956
29. D. Kohno, M. Nakata, F. Maekawa, K. Fujiwara, Y. Maejima, and M. Kuramochi Leptin suppresses ghrelin-induced activation of neuropeptide Y neurons in the arcuate nucleus via phosphatidylinositol 3-kinase- and phosphodiesterase 3-mediated pathway Endocrinology 148 2007 2251 2263
30. D. Kohno, H. Sone, Y. Minokoshi, and T. Yada Ghrelin raises [Ca2+]i via AMPK in hypothalamic arcuate nucleus NPY neurons Biochem Biophys Res Commun 366 2008 388 392
31. B. Kola, E. Hubina, S.A. Tucci, T.C. Kirkham, E.A. Garcia, and S.E. Mitchell Cannabinoids and ghrelin have both central and peripheral metabolic and cardiac effects via AMP-activated protein kinase J Biol Chem 280 2005 25196 25201
32. M. Lopez, R. Lage, A.K. Saha, D. Perez-Tilve, M.J. Vazquez, and L. Varela Hypothalamic fatty acid metabolism mediates the orexigenic action of ghrelin Cell Metab 7 2008 389 399
33. S. Luquet, F.A. Perez, T.S. Hnasko, and R.D. Palmiter NPY/AgRP neurons are essential for feeding in adult mice but can be ablated in neonates Science 310 2005 683 685
34. S. Luquet, C.T. Phillips, and R.D. Palmiter NPY/AgRP neurons are not essential for feeding responses to glucoprivation Peptides 28 2007 214 225
35. S. Malik, F. McGlone, D. Bedrossian, and A. Dagher Ghrelin modulates brain activity in areas that control appetitive behavior Cell Metab 7 2008 400 409
36. T.L. Martin, T. Alquier, K. Asakura, N. Furukawa, F. Preitner, and B.B. Kahn Diet-induced obesity alters AMP kinase activity in hypothalamus and skeletal muscle J Biol Chem 281 2006 18933 18941
37. Y. Minokoshi, T. Alquier, N. Furukawa, Y.B. Kim, A. Lee, and B. Xue AMP-kinase regulates food intake by responding to hormonal and nutrient signals in the hypothalamus Nature 428 2004 569 574
38. N. Murakami, T. Hayashida, T. Kuroiwa, K. Nakahara, T. Ida, and M.S. Mondal Role for central ghrelin in food intake and secretion profile of stomach ghrelin in rats J Endocrinol 174 2002 283 288
39. M. Nakazato, N. Murakami, Y. Date, M. Kojima, H. Matsuo, and K. Kangawa A role for ghrelin in the central regulation of feeding Nature 409 2001 194 198
40. S. Obici, Z. Feng, A. Arduini, R. Conti, and L. Rossetti Inhibition of hypothalamic carnitine palmitoyltransferase-1 decreases food intake and glucose production Nat Med 9 2003 756 761
41. H.R. Patel, Y. Qi, E.J. Hawkins, S.M. Hileman, J.K. Elmquist, and Y. Imai Neuropeptide Y deficiency attenuates responses to fasting and high-fat diet in obesity-prone mice Diabetes 55 2006 3091 3098
42. M. Perello, I. Sakata, S. Birnbaum, J.C. Chuang, S. Osborne-Lawrence, and S.A. Rovinsky Ghrelin increases the rewarding value of high-fat diet in an orexin-dependent manner Biol Psychiatry 67 2010 880 886
43. M. Perreault, N. Istrate, L. Wang, A.J. Nichols, E. Tozzo, and A. Stricker-Krongrad Resistance to the orexigenic effect of ghrelin in dietary-induced obesity in mice: reversal upon weight loss Int J Obes Relat Metab Disord 28 2004 879 885
44. P.S. Petersen, D.P. Woldbye, A.N. Madsen, K.L. Egerod, C. Jin, and M. Lang In vivo characterization of high Basal signaling from the ghrelin receptor Endocrinology 150 2009 4920 4930
45. P.T. Pfluger, H. Kirchner, S. Gunnel, B. Schrott, D. Perez-Tilve, and S. Fu Simultaneous deletion of ghrelin and its receptor increases motor activity and energy expenditure Am J Physiol Gastrointest Liver Physiol 294 2008 G610 G618
46. I. Sakata, J. Yang, C.E. Lee, S. Osborne-Lawrence, S.A. Rovinsky, and J.K. Elmquist Colocalization of ghrelin O-acyltransferase and ghrelin in gastric mucosal cells Am J Physiol Endocrinol Metab 297 2009 E134 E141
47. M.W. Schwartz, A.J. Sipols, J.L. Marks, G. Sanacora, J.D. White, and A. Scheurink Inhibition of hypothalamic neuropeptide Y gene expression by insulin Endocrinology 130 1992 3608 3616
48. Y.B. Shrestha, K. Wickwire, and S. Giraudo Effect of reducing hypothalamic ghrelin receptor gene expression on energy balance Peptides 30 2009 1336 1341
49. Y. Shuto, T. Shibasaki, A. Otagiri, H. Kuriyama, H. Ohata, and H. Tamura Hypothalamic growth hormone secretagogue receptor regulates growth hormone secretion, feeding, and adiposity J Clin Invest 109 2002 1429 1436
50. A.J. Sipols, D.G. Baskin, and M.W. Schwartz Effect of intracerebroventricular insulin infusion on diabetic hyperphagia and hypothalamic neuropeptide gene expression Diabetes 44 1995 147 151
51. G.R. Steinberg, and B.E. Kemp AMPK in health and disease Physiol Rev 89 2009 1025 1078
52. Y. Sun, N.F. Butte, J.M. Garcia, and R.G. Smith Characterization of adult ghrelin and ghrelin receptor knockout mice under positive and negative energy balance Endocrinology 149 2008 843 850
53. Y. Sun, P. Wang, H. Zheng, and R.G. Smith Ghrelin stimulation of growth hormone release and appetite is mediated through the growth hormone secretagogue receptor Proc Natl Acad Sci U S A 101 2004 4679 4684
54. G.S. Tannenbaum, M. Lapointe, A. Beaudet, and A.D. Howard Expression of growth hormone secretagogue-receptors by growth hormone-releasing hormone neurons in the mediobasal hypothalamus Endocrinology 139 1998 4420 4423
55. C. Theander-Carrillo, P. Wiedmer, P. Cettour-Rose, R. Nogueiras, D. Perez-Tilve, and P. Pfluger Ghrelin action in the brain controls adipocyte metabolism J Clin Invest 116 2006 1983 1993
56. B. Tiesjema, S.E. la Fleur, M.C. Luijendijk, M.A. Brans, E.J. Lin, and M.J. During Viral mediated neuropeptide Y expression in the rat paraventricular nucleus results in obesity Obesity (Silver Spring) 15 2007 2424 2435
57. Q. Tong, C.P. Ye, J.E. Jones, J.K. Elmquist, and B.B. Lowell Synaptic release of GABA by AgRP neurons is required for normal regulation of energy balance Nat Neurosci 2008
58. M. Tschop, M.A. Statnick, T.M. Suter, and M.L. Heiman GH-releasing peptide-2 increases fat mass in mice lacking NPY: indication for a crucial mediating role of hypothalamic agouti-related protein Endocrinology 143 2002 558 568
59. L. Wang, D.H. Saint-Pierre, and Y. Tache Peripheral ghrelin selectively increases Fos expression in neuropeptide Y - synthesizing neurons in mouse hypothalamic arcuate nucleus Neurosci Lett 325 2002 47 51
60. M.G. Willesen, P. Kristensen, and J. Romer Co-localization of growth hormone secretagogue receptor and NPY mRNA in the arcuate nucleus of the rat Neuroendocrinology 70 1999 306 316
61. M.J. Wolfgang, S.H. Cha, A. Sidhaye, S. Chohnan, G. Cline, and G.I. Shulman Regulation of hypothalamic malonyl-CoA by central glucose and leptin Proc Natl Acad Sci U S A 104 2007 19285 19290
62. M.J. Wolfgang, T. Kurama, Y. Dai, A. Suwa, M. Asaumi, and S. Matsumoto The brain-specific carnitine palmitoyltransferase-1c regulates energy homeostasis Proc Natl Acad Sci U S A 103 2006 7282 7287
63. M.J. Wolfgang, and M.D. Lane The role of hypothalamic malonyl-CoA in energy homeostasis J Biol Chem 281 2006 37265 37269
64. A. Woods, K. Dickerson, R. Heath, S.P. Hong, M. Momcilovic, and S.R. Johnstone Ca2+/calmodulin-dependent protein kinase kinase-beta acts upstream of AMP-activated protein kinase in mammalian cells Cell Metab 2 2005 21 33
65. K.E. Wortley, K.D. Anderson, K. Garcia, J.D. Murray, L. Malinova, and R. Liu Genetic deletion of ghrelin does not decrease food intake but influences metabolic fuel preference Proc Natl Acad Sci U S A 101 2004 8227 8232
66. J. Yang, M.S. Brown, G. Liang, N.V. Grishin, and J.L. Goldstein Identification of the acyltransferase that octanoylates ghrelin, an appetite-stimulating peptide hormone Cell 132 2008 387 396
67. W. Yin, J. Mu, and M.J. Birnbaum Role of AMP-activated protein kinase in cyclic AMP-dependent lipolysis In 3T3-L1 adipocytes J Biol Chem 278 2003 43074 43080
68. C.Y. Zhang, G. Baffy, P. Perret, S. Krauss, O. Peroni, and D. Grujic Uncoupling protein-2 negatively regulates insulin secretion and is a major link between obesity, beta cell dysfunction, and type 2 diabetes Cell 105 2001 745 755
69. T.J. Zhao, G. Liang, R.L. Li, X. Xie, M.W. Sleeman, and A.J. Murphy Ghrelin O-acyltransferase (GOAT) is essential for growth hormone-mediated survival of calorie-restricted mice Proc Natl Acad Sci U S A 107 2010 7467 7472
70. X. Zhu, Y. Cao, K. Voogd, and D.F. Steiner On the processing of proghrelin to ghrelin J Biol Chem 281 2006 38867 38870
71. J.M. Zigman, J.E. Jones, C.E. Lee, C.B. Saper, and J.K. Elmquist Expression of ghrelin receptor mRNA in the rat and the mouse brain J Comp Neurol 494 2006 528 548
72. J.M. Zigman, Y. Nakano, R. Coppari, N. Balthasar, J.N. Marcus, and C.E. Lee Mice lacking ghrelin receptors resist the development of diet-induced obesity J Clin Invest 115 2005 3564 3572