Biochemical characterization and structural analysis of a highly proficient cocaine esterase

Biochemistry

Volumn 41, Issue 41, 2002, Pages 12297-12307

  Turner, James M ^a   Larsen, Nicholas A ^a   Basran, Amrik ^b   Barbas III, Carlos F ^a   Bruce, Neil C ^b   Wilson, Ian A ^a   Lerner, Richard A ^a  

^a SCRIPPS RESEARCH INSTITUTE   (United States)

^b UNIVERSITY OF CAMBRIDGE   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

MUTATION;

ALCOHOLS; ANTIBODIES; DETOXIFICATION; ESTERS; HYDROLYSIS; METABOLITES; UREA;

BIOCHEMISTRY;

CARBOXYLESTERASE; ENZYME ANTIBODY; UREA;

ARTICLE; CIRCULAR DICHROISM; CRYSTAL STRUCTURE; ENZYME ACTIVE SITE; ENZYME DENATURATION; ENZYME KINETICS; ENZYME STRUCTURE; FLUORESCENCE; GENE MUTATION; IONIZATION; PH; PRIORITY JOURNAL; STRUCTURE ANALYSIS; TITRIMETRY;

BACTERIAL PROTEINS; BINDING SITES; BINDING SITES, ANTIBODY; CARBOXYLIC ESTER HYDROLASES; CATALYSIS; CATALYTIC DOMAIN; COCAINE; CRYSTALLIZATION; CRYSTALLOGRAPHY, X-RAY; HYDROGEN-ION CONCENTRATION; HYDROLYSIS; MUTAGENESIS, SITE-DIRECTED; PHENYLALANINE; PROTEIN BINDING; PROTEIN DENATURATION; PROTEIN FOLDING; PROTEIN STRUCTURE, TERTIARY; RHODOCOCCUS; STRUCTURE-ACTIVITY RELATIONSHIP; SUBSTRATE SPECIFICITY; TYROSINE; UREA;

BACTERIA (MICROORGANISMS);

EID: 0037108184     PISSN: 00062960     EISSN: None     Source Type: Journal    
DOI: 10.1021/bi026131p     Document Type: Article

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