Evaluation of anti-cocaine antibodies and a cocaine vaccine in a rat self-administration model

Psychopharmacology

Volumn 148, Issue 3, 2000, Pages 251-262

  Kantak, Kathleen M ^a   Collins, Stephanie L ^a   Lipman, Elizabeth G ^a   Bond, Julian ^b   Giovanoni, Kate ^b   Fox, Barbara S ^b,c  

^a BOSTON UNIVERSITY   (United States)

^b ImmuLogic Pharmaceutical Corporation   (United States)

^c Addiction Therapies Inc   (United States)

Author keywords

Active immunization; Anti cocaine antibody; Cocaine; Cocaine vaccine; IPC 1010; Second order schedule of drug delivery; Self administration

Indexed keywords

IPC 1010; MO 240; MONOCLONAL ANTIBODY; UNCLASSIFIED DRUG; VACCINE;

ACTIVE IMMUNIZATION; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIBODY BLOOD LEVEL; ARTICLE; BEHAVIOR; COCAINE DEPENDENCE; CONCENTRATION (PARAMETERS); CONTROLLED STUDY; DRUG EFFICACY; DRUG SELF ADMINISTRATION; MALE; NONHUMAN; PASSIVE IMMUNIZATION; PRIORITY JOURNAL; RAT;

EID: 0034092902     PISSN: 00333158     EISSN: None     Source Type: Journal    
DOI: 10.1007/s002130050049     Document Type: Article

References (37)

1. Balster RL, Schuster CR (1973a) A comparison of d-amphetamine, 1-amphetamine and methamphetamine self-administration in rhesus monkeys. Pharmacol Biochem Behav 1:67-71
2. Balster RL, Schuster CR (1973b) Fixed-interval schedule of cocaine reinforcement: effect of dose and infusion duration. J Exp Anal Behav 20:119-129
3. Benowitz NL (1993) Clinical pharmacology and toxicology of cocaine. Pharmacol Toxicol 72:3-12
4. Bergman J, Kamien JB, Spealman RD (1990) Antagonism of cocaine self-administration by selective dopamine D1 and D2 antagonists. Behav Pharmacol 1:355-363
5. Bonese KF, Wainer BH, Fitch FW, Rothberg RM, Schuster CR (1974) Changes in heroin self-administration by a rhesus monkey after morphine immunization. Nature 252:708-710
6. Booze RM, Lehner AF, Wallace DR, Welch MA, Mactutus CF (1997) Dose-response cocaine pharmacokinetics and metabolite profile following intravenous administration and arterial sampling in unanesthetized, freely moving male rats. Neurotoxicol Teratol 19:7-15
7. Caine SB, Koob GF (1994) Effects of dopamine D-1 and D-2 antagonists on cocaine self-administration under different schedules of reinforcement in the rat. J Pharmacol Exp Ther 270:209-218
8. Carrera MRA, Ashley JA, Parsons LH, Wirschinag P, Koob GF, Janda KD (1995) Suppression of psychoactive effects of cocaine by active immunization. Nature 378:727-730
9. Carroll FI, Lewin AH, Biwas J (1994) Chemical approaches to the treatment of cocaine abuse. Pharm News 1:11-16
10. Dickerson LW, Rodak DJ, Kuhn FE, Wahlstrom SK, Tessel RE, Visner MS, Schaer GL, Gillis RA (1999) Cocaine-induced cardiovascular effects: lack of evidence for a central nervous system site of action based on hemodynamic studies with cocaine methiodide. J Cardiovasc Pharmacol 33:36-42
11. Ettinger RH, Ettinger WF, Harless WE (1997) Active immunization with cocaine-protein conjugate attenuates cocaine effects. Pharmacol Biochem Behav 58:215-220
12. Fox BS, Kantak KM, Edwards MA, Black KM, Bollinger BK, Botka AJ, French TL, Thompson TL, Schad VC, Greenstein JL, Gefter ML, Exley MA, Swain PA, Briner TJ (1996) Efficacy of a therapeutic cocaine vaccine in rodent models. Nat Med 2:1129-1132
13. Glowa JR, Wojnicki FHE, Matecka D, Bacher JD, Mansbach RS, Balster RL, Rice KC (1995) Effects of dopamine reuptake inhibitors on food- and cocaine-maintained responding: I. dependence on unit dose of cocaine. Exp Clin Psychopharmacol 3:219-231
14. Gold MS (1993) Opiate addiction and the locus coeruleus. The clinical utility of clonidine, naltrexone, methadone, and buprenorphine. Psychiatr Clin North Am 16:61-73
15. Goldberg SR (1973) Comparable behavior maintained under fixed-ratio and second-order schedules of food presentation, cocaine injection or d-amphetamine injection in the squirrel monkey. J Pharmacol Exp Ther 186:18-30
16. Goldberg SR, Spealman RD, Kelleher RT (1979) Enhancement of drug-seeking behavior by environmental stimuli associated with cocaine or morphine injections. Neuropharmacology 18: 1015-1017
17. Goldberg SR, Kelleher RT, Goldberg DM (1981) Fixed-ratio responding under second-order schedules of food presentation or cocaine injection. J Pharmacol Exp Ther 218:271-281
18. Hall WC, Talbert RL, Ereshefsky L (1990) Cocaine abuse and its treatment. Pharmacotherapy 10:47-65
19. Johanson CE, Fischman MW (1989) The pharmacology of cocaine related to its abuse. Pharmacol Rev 41:3-52
20. Johanson CE, Schuster CR (1975) A choice procedure for drug reinforcers: cocaine and methylphenidate in the rhesus monkey. J Pharmacol Exp Ther 193:676-688
21. Kantak KM, Collins SL, Bond J, Marr J (1999) Comparison of the effects of the cocaine vaccine IPC-1010 on responding maintained by cocaine and food delivery (abstract). Abstracts of the 61st Annual Meeting of the College on Problems of Drug Dependence, Acapulco, Mexico
22. Katz JL, Newman AH, Izenwasser S (1997) Relations between heterogeneity of dopamine transporter binding and function and the behavioral pharmacology of cocaine. Pharmacol Biochem Behav 57:505-512
23. Kelleher RT (1966) Conditioned reinforcement in second-order schedules. J Exp Anal Behav 9:475-485
24. Kosten TR, Morgan C, Kleber HD (1991) Treatment of heroin addicts using buprenorphine. Am J Drug Alcohol Abuse 17: 119-128
25. Kreek MJ (1992) Rationale for maintenance pharmacotherapy of opiate dependence. Res Publ Assoc Res Nerv Ment Dis 70:205-230
26. Landry DW, Zhao K, Yang GX, Glickman M, Georgiadis TM (1993) Antibody-catalyzed degradation of cocaine. Science 259:1899-1901
27. Mets B, Winger G, Cabrera C, Seo S, Jamdar S, Yang G, Zhao K, Briscoe RJ, Almonte, R, Woods JH, Landry DW (1998) A catalytic antibody against cocaine prevents cocaine's reinforcing and toxic effects in rats. Proc Natl Acad Sci USA 95: 10176-10181
28. Morishima HO, Whittington RA, Iso A, Cooper TB (1999) The comparative toxicity of cocaine and its metabolites in conscious rats. Anesthesiology 90:1684-1690
29. O'Brien CP (1997) A range of research-based pharmacotherapies for addiction. Science 278:66-70
30. Paly D, Jatlow P, Van Dyke C, Jeri R, Byck R (1982) Plasma cocaine concentrations during cocaine paste smoking. Life Sci 30:731-738
31. Pan WJ, Hedaya MA (1999) Cocaine and alcohol interactions in the rat: contribution of cocaine metabolites to the pharmacological effects. J Pharm Sci 88:468-476
32. Peltier R, Schenk S (1991) GR38032F, a serotonin 5-HT3 antagonist, fails to alter cocaine self-administration in rats. Pharmacol Biochem Behav 39:133-136
33. Singh S, Basmadjian GP, Avor KS, Pouw B, Seale TW (1997) Synthesis and ligand binding studies of 4′-iodobenzoyl esters of tropanes and piperidines at the dopamine transporter. J Med Chem 40:2474-2481
34. Sparenborg S, Vocci F, Zukin S (1997) Peripheral cocaine-blocking agents: new medications for cocaine dependence. Drug Alcohol Depend 48:149-151
35. Volkow ND, Wang G-J, Fischman MW, Foltin RW, Fowler JS, Abumrad NN, Vitkun S, Logan J, Gateley SJ, Pappas N, Hitzemann R, Shea CE (1997) Relationship between subjective effects of cocaine and dopamine transporter occupancy. Nature 386:827-830
36. Wise RA, Ranaldi R (1996) Cocaine vaccines revisited. Nat Med 2:1073-1074
37. Woods JH, Winger GD, France CP (1987) Reinforcing and discriminative stimulus effects of cocaine: analysis of pharmacological mechanisms. In: Fisher S, Raskin A, Uhlenhuth E (eds) Cocaine: clinical and biobehavioral aspects. Oxford University Press, New York, pp 21-65