Structure-based design and protein engineering of intersubunit disulfide bonds in gonadotropins

Nature Biotechnology

Volumn 15, Issue 7, 1997, Pages 658-662

  Heikoop, Judith C ^a   van den Boogaart, Paul ^a   Mulders, John W M ^a   Grootenhuis, Peter D J ^a  

^a NV ORGANON   (Netherlands)

Author keywords

Follicle stimulating hormone; Human choriogonadotropin; Luteinizing hormone; Molecular modeling; Protein engineering; Rational design

Indexed keywords

CHORIONIC GONADOTROPIN; CYSTINE; DISULFIDE; FOLLITROPIN; GONADOTROPIN; LUTEINIZING HORMONE; PROTEIN SUBUNIT;

ALPHA CHAIN; ANIMAL CELL; ARTICLE; BETA CHAIN; CHO CELL; CONTROLLED STUDY; COVALENT BOND; DISULFIDE BOND; DRUG DESIGN; DRUG STRUCTURE; GENETIC ENGINEERING; MUTANT; NONHUMAN; PRIORITY JOURNAL; SHELF LIFE; THERMOSTABILITY;

ANIMALS; BIOTECHNOLOGY; CHO CELLS; CHORIONIC GONADOTROPIN; CRICETINAE; CYSTINE; DISULFIDES; DRUG DESIGN; DRUG STABILITY; FOLLICLE STIMULATING HORMONE; GONADOTROPINS; HUMANS; LUTEINIZING HORMONE; MODELS, MOLECULAR; MUTAGENESIS, SITE-DIRECTED; PROTEIN CONFORMATION; PROTEIN ENGINEERING; RECEPTORS, LH; SIGNAL TRANSDUCTION; TEMPERATURE; TRANSFECTION;

ANIMALIA;

EID: 0030873203     PISSN: 10870156     EISSN: 15461696     Source Type: Journal    
DOI: 10.1038/nbt0797-658     Document Type: Article

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