Evaluation of the anticocaine monoclonal antibody GNC92H2 as an immunotherapy for cocaine overdose

Pharmacology Biochemistry and Behavior

Volumn 81, Issue 4, 2005, Pages 709-714

  Carrera, M Rocío A ^b   Trigo, José Manuel ^a   Wirsching, Peter ^b   Roberts, Amanda J ^b   Janda, Kim D ^b  

^a UNIVERSIDAD COMPLUTENSE DE MADRID   (Spain)

^b SCRIPPS RESEARCH INSTITUTE   (United States)

Author keywords

Cocaine induced toxicity; GNC92H2; Immunotherapy; Mice; Monoclonal antibody

Indexed keywords

COCAINE; MONOCLONAL ANTIBODY; MONOCLONAL ANTIBODY GNC92H2; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BEHAVIOR; CONTROLLED STUDY; DEATH; DISEASE MODEL; DRUG INFUSION; DRUG MEGADOSE; IMMUNOTHERAPY; INJECTION; INTOXICATION; INTRAVENOUS CATHETER; JUGULAR VEIN; LD 50; MALE; MOUSE; NONHUMAN; PRIORITY JOURNAL; SEIZURE; TIME; TOXICITY;

ANIMALS; ANTIBODIES, MONOCLONAL; BEHAVIOR, ANIMAL; COCAINE; DOSE-RESPONSE RELATIONSHIP, DRUG; IMMUNOTHERAPY; MALE; MICE; OVERDOSE; SEIZURES; SURVIVAL RATE; TIME FACTORS;

ANIMALIA;

EID: 23944507261     PISSN: 00913057     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.pbb.2005.04.018     Document Type: Article

References (40)

1. B.K. Alldredge, D.H. Lowenstein, and R.P. Simon Seizures associated with recreational drug abuse Neurology 39 1989 1037 1039
2. O. Bagasra, L.J. Forman, A. Howeedy, and P. Whittle A potential vaccine for cocaine abuse prophylaxis Immunopharmacology 27 1994 79 84
3. C.K. Bates Medical risks of cocaine use West Med 148 1988 440 444
4. N.L. Benowitz, J. Rosengerg, and C.E. Becker Cardiopulmonary catastrophes in drug-overdosed patients Med Clin North Am 63 1979 267 296
5. M.A. Bozarth, and R.A. Wise Toxicity associated with long-term intravenous heroin and cocaine self-administration in the rat JAMA 5 1985 81 83
6. R.J. Briscoe, P.M. Jeanville, C. Cabrera, T.J. Baird, and J.H. Woods A catalytic antibody against cocaine's cardiovascular effects in mice: a dose and time course analysis Int Immunopharmacol 1 2001 1189 1198
7. D.O. Calligaro, and M.E. Eldefrawi High affinity sterospecific binding of [3H}cocaine in striatum and its relationship to the dopamine transporter Membr Biochem 88 7 1987 87 106
8. M.R.A. Carrera, J.A. Ashley, L.H. Parsons, P. Wirsching, G.F. Koob, and K.D. Janda Suppression of psychoactive effects of cocaine by active immunization Nature 378 1995 727 730
9. M.R.A. Carrera, J.A. Ashley, B. Zhou, P. Wirsching, G.F. Koob, and K.D. Janda Cocaine vaccines: antibody protection against relapse in a rat model Proc Natl Acad Sci U S A 32 2000 6202 6206
10. M.R.A. Carrera, J.A. Ashley, P. Wirsching, G.F. Koob, and K.D. Janda A second generation vaccine protects against the psychoactive effects of cocaine Proc Natl Acad Sci U S A 98 2001 1988 1992
11. J.D. Catravas, and I.W. Waters Acute cocaine intoxication in the conscious dog: studies on the mechanism of lethatlity J Pharmacol Exp Ther 217 1981 350 356
12. M. Coy-Kwong, and R.B. Lipton Dystonia related to cocaine withdrawal: a case report and pathogenic hypothesis Neurology 39 1989 996 997
13. L.L. Cregler, and H. Mark Relation of acute myocardial infarction to cocaine abuse Am J Cardiol 1 1985 794
14. R.W. Derlet, and T.E. Albertson Diazepam in the prevention of seizures and death in cocaine-intoxicated rats Enn Emerg Med 18 1989 542 546
15. A. Dhuna, A. Pascual-Leone, F. Langerdorf, and D.C. Anderson Epiloptogenic properties of cocaine in humans Neurotoxicology 12 1991 621 626
16. H.C. Farrar, and GL. Kearns Cocaine: clinical pharmacology and toxicology J Pediatr 115 1989 665 675
17. B.S. Fox, K.M. Kantak, M.A. Edwards, K.M. Black, B.K. Bollinger, and A.J. Botka Efficacy of a therapeutic cocaine vaccine in rodent models Nat Med 2 1996 1073 1074
18. M.W. Garber, and D. Flaherty Cocaine and sudden death Am Fam Phys 4 1987 174 185
19. F.R. George Cocaine toxicity: genetic differences in cocaine-induced lethality in rats Pharmacol Biochem Behav 38 1991 893 895
20. A.H. Gradman Cardiac effects of cocaine: a review Yale J Biol Med 61 1988 137 147
21. W.L. Hearn, S. Rose, J. Wagner, A. Ciarleglio, and D.C. Mash Cocaethylene is more potent than cocaine in mediating lethality Pharmacol Biochem Behav 39 1991 531 533
22. S. Jonsson, M. O'Meara, and J.B. Young Acute cocaine poisoning. Importance of treating seizures and acidosis Am J Med 75 1983 1061 1064
23. K.M. Kantak, S.L. Collins, E.G. Lipman, J. Bond, K. Giovanoni, and B.S. Fox Evaluation of anti-cocaine antibodies and a cocaine vaccine in a rat self-administration model Psychopharmacolgy (Berl) 148 2000 251 262
24. K.M. Kantak, S.L. Collins, J. Bond, and B.S. Fox Time course of changes in cocaine self-administration behavior in rats during immunization with the cocaine vaccine IPC-1010 Psychopharmacology (Berl) 153 2001 334 340
25. L.T. Kennedy, and I. Hanbauer Sodium-sensitive cocaine binding to rat striatal membrane: possible relationship to dopamine uptake sites J Neurochem 41 1983 172 178
26. S.Z. Langer, and M.A. Enero The potentiation of responses to adrenergic nerve stimulation in the presence of cocaine: its relationship to the metabolic fate of released norepinephrine J Pharmacol Exp Ther 191 1974 431 443
27. K.A. Loper Clinical toxicology of cocaine Med Toxicol Adverse Drug Exp 4 1989 174 185
28. D.H. Lowenstein, S.M. Massa, M.C. Rowbotham, S.D. Collins, H.E. McKinney, and R.P. Simon Acute neurologic and psychiatric complications associated with cocaine abuse Am J Med 83 1987 841 846
29. B. Mets, G. Winger, C. Cabrera, S. Seo, and S. Jamdar A catalytic antibody against cocaine prevents cocaine's reinforcing and toxic effects in rats Proc Natl Acad Sci U S A 18 1998 10176 10181
30. K.A. Miller, J.M. Witkin, J.T. Ungard, and M. Gasior Pharmacological and behavioral characterization of cocaine-kindled seizures in mice Psychopharmacology 148 2000 74 82
31. R.E. Mittleman, and C.V. Wetli Death caused by recreational cocaine use. An update JAMA 12 1984 1889 1893
32. J.A. Myers, and M.P. Earnest Generalized seizures and cocaine abuse Neurology 34 1984 675 676
33. L.E. O'Dell, F.R. George, and M.C. Ritz Antidepressant drugs appear to enhance cocaine-induced toxicity Exp Clin Psychopharmacol 8 2000 133 141
34. L.E. O'Dell, M.J. Kreifeldt, F.R. George, and M.C. Ritz The role of serotonin(2) receptors in mediating cocaine-induced convulsions Pharmacol Biochem Behav 65 2000 677 681
35. R.T. Rappolt, G.R. Gay, and D.S. Inaba Propranolol: a specific antagonist to cocaine Clin Toxicol 10 1977 265 271
36. M.E. Reith, H. Sershen, D.L. Allen, and A. Lajtha A portion of [3H]cocaine binding in brain is associated with serotonergic neurons Mol Pharmacol 23 1983 6000 6006
37. M.C. Ritz, and F.R. George Cocaine-induced seizures and lethality appear to be associated with distinct central nervous system binding sites J Pharmacol Exp Ther 264 1993 1333 1343
38. SAMHSA. Substance Abuse and Mental Health Services Administration. Year-end preliminary estimates from the 1996 drug abuse warning network. U.S. Department of Health Human Services Publication No. (SMA); 98-3175, Rockville, MD.
39. J. Sharkey, M.C. Ritz, J.A. Scheden, R.C. Hanson, and M.J. Kuhar Cocaine inhibits muscarinic cholinergic receptors in the heart and brain J Pharmacol Exp Ther 246 1988 1048 1052
40. M.C. Wilson, and J.M. Holbrook Intravenous cocaine lethality in the rat J Pharmcol Exp Ther 217 1981 350 356