Oxygen- and glucose-dependent regulation of central carbon metabolism in Pichia anomala

Applied and Environmental Microbiology

Volumn 70, Issue 10, 2004, Pages 5905-5911

  Fredlund, Elisabeth ^a   Blank, Lars M ^b   Schnürer, Johan ^a   Sauer, Uwe ^b   Passoth, Volkmar ^a  

^a SWEDISH UNIVERSITY OF AGRICULTURAL SCIENCES   (Sweden)

^b ETH ZURICH   (Switzerland)

Author keywords

[No Author keywords available]

Indexed keywords

BIOMASS; ENZYMES; GLUCOSE; METABOLISM; OXYGEN;

AEROBIC BATCH CULTURE; CARBON METABOLISM;

MICROBIOLOGY;

ACETIC ACID; ACETIC ACID ETHYL ESTER; ALCOHOL; ALCOHOL DEHYDROGENASE; CARBON; CARBON 13; GLUCOSE; GLYCEROL; OXYGEN; PYRUVATE DECARBOXYLASE; SUCCINIC ACID;

BIOLOGICAL CONTROL; YEAST;

AEROBIC METABOLISM; ARTICLE; BIOLOGICAL PEST CONTROL; BIOMASS; CARBON METABOLISM; CITRIC ACID CYCLE; CONTROLLED STUDY; ENERGY METABOLISM; ENZYME ACTIVITY; FERMENTATION; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HYPOXIA; METABOLIC REGULATION; NONHUMAN; PICHIA; PICHIA ANOMALA; SACCHAROMYCES;

ACETATES; ALCOHOL DEHYDROGENASE; CARBON; CITRIC ACID CYCLE; ETHANOL; FERMENTATION; FOOD MICROBIOLOGY; GLUCOSE; KINETICS; MODELS, BIOLOGICAL; OXYGEN; PENTOSE PHOSPHATE PATHWAY; PEST CONTROL, BIOLOGICAL; PICHIA; PYRUVATE DECARBOXYLASE; WINE;

PICHIA; PICHIA ANOMALA; SACCHAROMYCES; TRIXIS;

EID: 8144231101     PISSN: 00992240     EISSN: None     Source Type: Journal    
DOI: 10.1128/AEM.70.10.5905-5911.2004     Document Type: Article

References (59)

1. Bergmeyer, H. (ed.). 1974. Methods in enzymatic analysis, vol. 1. Academic Press, New York, N.Y.
2. Blank, L., and U. Sauer. 2004. TCA cycle activity in Saccharomyces cerevisiae is a function of the environmentally determined specific growth and glucose uptake rates. Microbiology 150:1085-1093.
3. Boles, E., J. Heinisch, and F. K. Zimmermann. 1993. Different signals control the activation of glycolysis in the yeast Saccharomyces cerevisiae. Yeast 9:761-770.
4. Bradbury, S., J. Clark, C. Steinman, and C. Jakoby. 1975. Aldehyde dehydrogenase from baker's yeast. Methods Enzymol. 41:354-360.
5. Bradford, M. M. 1976. A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding. Anal. Biochem. 72:248-254.
6. Buchs. J. 2001. Introduction to advantages and problems of shaken cultures. Biochem. Eng. J. 7:91-98.
7. Ciriacy, M., and I. Breitenbach. 1979. Physiological effects of seven different blocks in glycolysis in Saccharomyces cerevisiae. J. Bacteriol. 139:152-160.
8. Davies, R., E. Falkiner, J. Wilkinson, and J. Peel. 1951. Ester formation by yeast, 1. Ethyl acetate formation by Hansenula species. Biochem. J. 49:58-60.
9. De Deken, R. 1966. The Crabtree effect: a regulatory system in yeast. J. Gen. Microbiol. 44:149-156.
10. Dellweg, H., M. Rizzi, H. Methner, and D. Debus. 1984. Xylose fermentation by yeasts, comparison of Pachysolen tannophilus and Pichia stipitis. Biotechnol. Lett. 6:395-400.
11. Druvefors, U., N. Jonsson, M. E. Boysen, and J. Schnürer. 2002. Efficacy of the biocontrol yeast Pichia anomala during long-term storage of moist feed grain under different oxygen and carbon dioxide regimens. FEMS Yeast Res. 2:389-394.
12. Elsworth, R., V. Williams, and R. Harris-Smith. 1957. The effect of oxygen supply on the rate of growth of Aerobacter cloacea. J. Appl. Chem. 7:269-274.
13. Fiaox, J., Z. P. Cakar, M. Sonderegger, K. Wüthrich, T. Szyperski, and U. Sauer. 2003. Metabolic-flux profiling of the yeasts Saccharomyces cerevisiae and Pichia slipitis. Eukaryot. Cell 2:170-180.
14. Fischer, E., and U. Sauer. 2003. Metabolic flux profiling of Escherichia coll mutants in central carbon metabolism using GC-MS. Eur. J. Biochem. 270: 880-891.
15. 13C constraints. Anal. Biochem. 325:308-316.
16. Flikweert, M. T., L. van der Zanden, W. Janssen, H. Y. Steensma, J. P. van Dijken, and J. T. Pronk. 1996. Pyruvate decarboxylase: an indispensable enzyme for growth of Saccharomyces cerevisiae on glucose. Yeast 12:247-257.
17. Fredlund, E., A. Broberg, M. E. Boysen, L. Kenne, and J. Schnürer. 2004. Metabolite profiles of the biocontrol yeast Pichia anomala J121 grown under oxygen limitation. Appl. Microbiol. Biotechnol. 64:403-409.
18. Fredlund, E., U. Druvefors, K.-J. Lingsten, M. E. Boysen, and J. Schnürer. 2002. Physiological characteristics of the biocontrol yeast Pichia anomala J121. FEMS Yeast Res. 2:395-402.
19. Fredlund, E., U. Ä. Druvefors, M. N. Olstorpe, V. Passoth, and J. Schnürer. 2004. Influence of ethyl acetate production and ploidy on the anti-mould activity of Pichia anomala. FEMS Microbiol. Lett. 238:133-137.
20. Gancedo, J. M. 1998. Yeast carbon catabolite repression. Microbiol. Mol. Biol. Rev. 62:334-361.
21. Gombert, A. K., M. M. dos Santos, B. Christensen, and J. Nielsen. 2001. Network identification and flux quantification in the central metabolism of Saccharomyces cerevisiae under different conditions of glucose repression. J. Bacteriol. 183:1441-1451.
22. Jijakli, M., and P. Lepoivre. 1998. Characterization of an exo-β-1,3-glucanase produced by Pichia anomala strain K, antagonist of Botrytis cinerea on apples. Phytopathology 88:335-343.
23. Kiers, J., A. M. Zeeman, M. Luttik, C. Thiele, J. I. Castrillo, H. Y. Steensma, J. P. van Dijken, and J. T. Pronk. 1998. Regulation of alcoholic fermentation in batch and chemostat cultures of Kluyveromyces lactis CBS 2359. Yeast 14:459-469.
24. Kosse, D., H. Seller, R. Araann, W. Ludwig, and S. Scherer. 1997. Identification of yoghurt-spoiling yeasts with 18S rRNA-targeted oligonucleotide probes. Syst. Appl. Microbiol. 20:468-480.
25. Lanciotti, R., M. Sinigaglia, F. Cardini, and M. E. Guerzoni. 1998. Mansenula anomala as spoilage agent of cream-filled cakes. Microbiol. Res. 153:145-148.
26. Loureiro, V., and M. Malfeito-Ferreira. 2003. Spoilage yeasts in the wine industry. Int. J. Food Microbiol. 86:23-50.
27. Maaheimo, H., J. Fiaux, Z. P. Cakar, J. E. Bailey, U. Sauer, and T. Szyperski. 2001. Central carbon metabolism of Saccharomyces cerevisiae explored by biosynthetic fractional C-13 labeling of common amino acids. Eur. J. Biochem. 268:2464-2479.
28. Malcorps, P., J. Cheval, S. Jamil, and J. P. Dufour. 1992. A new model for the regulation of ester synthesis by alcohol acetyltransferase in Saccharomyces cerevisiae during fermentation. ASBC J. 49:47-53.
29. Masih, E. I., I. Alie, and B. Paul. 2000. Can the grey mould disease of the grape-vine be controlled by yeast? FEMS Microbiol. Lett. 189:233-237.
30. Mason, A. B., and J. P. Dufour. 2000. Alcohol acetyltransferases and the significance of ester synthesis in yeast. Yeast 16:1287-1298.
31. Mauricio, J., J. Moreno, E. Valero, L. Zea, M. Medina, and J. Ortega. 1993. Ester formation and specific activities of in vitro alcohol acetyltransferase and esterase by Saccharomyces cerevisiae during grape must fermentation. J. Agric. Food Chem. 41:2086-2091.
32. Mingorance-Cazorla, L., J. M. Clemente-Jiménez, S. Martínez-Rodríguez, F. J. Las Heras-Vázquez, and F. Rodríguez-Vico. 2003. Contribution of different natural yeasts to the aroma of two alcoholic beverages. World J. Microbiol. Biotechnol. 19:297-304.
33. Moller, K., B. Christensen, J. Förster, J. Piskur, J. Nielsen, and L. Olsson. 2002. Aerobic glucose metabolism of Saccharomyces kluyveri: growth, metabolite production, and quantification of metabolic fluxes. Biotechnol. Bioeng. 77:186-193.
34. Oda, S., Y. Inada, A. Kobayashi, A. Kalo, N. Matsudomi, and H. Ohta. 1996. Coupling of metabolism and bioconversion: microbial esterification of citronellol with acetyl coenzyme A produced via metabolism of glucose in an interface bioreactor. Appl. Environ. Microbiol. 62:2216-2220.
35. 2-regulated promoter. Enzyme Microb. Technol. 26:781-784.
36. Passoth, V., and J. Schnürer. 2003. Non-conventional yeasts in antifungal application, p. 297-330. In H. de Winde (ed.), Functional genetics of industrial yeasts, vol. 2. Springer Verlag, Berlin, Germany.
37. Passoth, V., M. Zimmermann, and U. Klinner. 1996. Peculiarities of the regulation of fermentation and respiration in the Crabtree-negative, xylose-fermenting yeast Pichia stipitis. Appl. Biochem. Biotechnol. 58:201-212.
38. Petersson, S., and J. Schnürer. 1998. Pichia anomala as a biocontrol agent of Penicillium roquefoni in high-moisture wheat, rye, barley, and oats stored under airtight conditions. Can. J. Microbiol. 44:471-476.
39. Plata, C., C. Millan, J. C. Mauricio, and J. M. Ortega. 2003. Formation of ethyl acetate and isoamyl acetate by various species of wine yeasts. Food Microbiol. 20:217-224.
40. Plata, M. O., J. C. Mauricio, C. Millan, and J. M. Ortega. 1998. In vitro specific activity of alcohol acetyltransferase and esterase in two flor yeast strains during biological aging of sherry wines. J. Ferment. Bioeng. 85:369-374.
41. Postma, E., C. Verduyn, W. A. Scheffers, and J. P. van Dijken. 1989. Enzymic analysis of the Crabtree effect in glucose-limited chemostat cultures of Saccharomyces cerevisiae. Appl. Environ. Microbiol. 55:468-477.
42. Rapp, A., and H. Mandary. 1986. Wine aroma. Experientia 42:873-884.
43. Rodrigues, F., M. Côrte-Real, C. Leão, J. P. van Dyken, and J. T. Pronk. 2001. Oxygen requirements of the food spoilage yeast Zygosaccharomyces bailii in synthetic and complex media. Appl. Environ. Microbiol. 67:2123-2128.
44. Rojas, V., J. V. Gil, P. Manzanares, R. Gavara, F. Pinaga, and A. Flors. 2002. Measurement of alcohol acetyltransferase and ester hydrolase activities in yeast extracts. Enzyme Microb. Technol. 30:224-230.
45. Rojas, V., J. V. Gil, F. Piñaga, and P. Manzanares. 2003. Acetate ester formation in wine by mixed cultures in laboratory fermentations. Int. J. Food Microbiol. 86:181-188.
46. Rojas, V., J. V. Gil, F. Piñaga, and P. Manzanares. 2001. Studies on acetate ester production by non-Saccharomyces wine yeasts. Int. J. Food Microbiol. 70:283-289.
47. Sauer, U. 2004. High-throughput phenomics: experimental methods for mapping fluxomes. Curr. Opin. Biotechnol. 15:58-63.
48. Sauer, U., D. Lasko, J. Fiaux, M. Hochuli, R. Glaser, T. Szyperski, K. Wüthrich, and J. Bailey. 1999. Metabolic flux ratio analysis of genetic and environmental modulations of Escherichia coli central carbon metabolism. J. Bacteriol. 181:6679-6688.
49. Skoog, K., H. Jepsson, and B. Hahn-Hägerdal. 1992. The effect of oxygenation on glucose fermentation with Pichia stipitis. Appl. Biochem. Biotechnol. 34/35:369-375.
50. Tabachnick, J., and M. Joslyn. 1953. Formation of esters by yeast. I. The production of ethyl acetate by standing surface cultures of Hansenula anomala. J. Bacteriol. 65:1-9.
51. Ullrich, J. 1970. Yeast pyruvate decarboxylase (2-oxoacid carboxy-lyase, EC 4.1.1.1.) assay of thiamine pyrophosphate. Methods Enzymol. 18:109-115.
52. van Dijken, J., and A. Scheffers. 1986. Redox balances in the metabolism of sugars by yeasts. FEMS Microbiol. Rev. 32:199-224.
53. van Hoek, P., J. P. van Dijken, and J. T. Pronk. 2000. Regulation of fermentative capacity and levels of glycolytic enzymes in chemostat cultures of Saccharomyces cerevisiae. Enzyme Microb. Technol. 26:724-736.
54. Van Urk, H., W. S. L. Voll, W. A. Scheffers, and J. P. Van Dijken. 1990. Transient-state analysis of metabolic fluxes in Crabtree-positive and Crabtree-negative yeasts. Appl. Environ. Microbiol. 56:281-287.
55. Visser, W., W. A. Scheffers, W. H. Batenburg-Van der Vegte, and J. P. van Dijken. 1990. Oxygen requirements of yeasts. Appl. Environ. Microbiol. 56: 3785-3792.
56. Wills, C., and J. Phelps. 1975. A technique for the isolation of yeast alcohol dehydrogenase mutants with altered substrate specificity. Arch. Biochem. Biophys. 167:627-637.
57. Wittman, C., M. Hans, and E. Heinzle. 2002. In vivo analysis of intracellular amino acid labeling by GC/MS. Anal. Biochem. 307:379-382.
58. Yoshioka, K., and N. Hashimoto. 1983. Cellular fatty acid and ester formation by brewer's yeast. Agric. Biol. Chem. 47:2287-2294.
59. Yoshioka, K., and N. Hashimoto. 1981. Ester formation by alcohol acetyltransferase from brewer's yeast. Agric. Biol. Chem. 45:2183-2190.