Regulation of fermentative capacity and levels of glycolytic enzymes in chemostat cultures of Saccharomyces cerevisiae

Enzyme and Microbial Technology

Volumn 26, Issue 9-10, 2000, Pages 724-736

  Van Hoek, Pim ^a   Van Dijken, Johannes P ^a   Pronk, Jack T ^a  

^a DELFT UNIVERSITY OF TECHNOLOGY   (Netherlands)

Author keywords

Alcoholic fermentation; Bakers' yeast; Chemostat cultures; Fermentative capacity

Indexed keywords

BIOMASS; CELL CULTURE; CHEMOSTATS; ENZYMES; FERMENTATION; GLUCOSE; METABOLITES;

ALCOHOLIC FERMENTATION; CHEMOSTAT CULTURE; FERMENTATIVE CAPACITY; GLYCOLYTIC ENZYME; SACCHAROMYCES CEREVISIAE;

YEAST;

ALCOHOL DEHYDROGENASE; GLYCOLYTIC ENZYME; PHOSPHOGLYCERATE KINASE; PYRUVATE DECARBOXYLASE;

BIOMASS; CELL METABOLISM; CHEMOSTAT; CONFERENCE PAPER; ENZYME ACTIVITY; ENZYME ASSAY; ENZYME REGULATION; FERMENTATION; NONHUMAN; OXYGEN CONSUMPTION; PROTEIN CONTENT; SACCHAROMYCES CEREVISIAE; STRAIN DIFFERENCE;

SACCHAROMYCES CEREVISIAE;

EID: 0034213554     PISSN: 01410229     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0141-0229(00)00164-2     Document Type: Conference Paper

References (44)

1. Chen S.L., Chiger M. Production of baker's yeast. Moo-Young M. Comprehensive biotechnology. Vol. 3:1985;429-455 Pergamon Press, Oxford, UK.
2. Reed G, Nagodawithana TW. Yeast technology, 2nd ed. New York, Van Nostrand Reinhold, 1991.
3. De Deken R.H. The Crabtree effect a regulatory system in yeast . J Gen Microbiol. 44:1966;149-156.
4. Petrik M., Käppeli O., Fiechter A. An expanded concept for glucose effect in the yeast Saccharomyces uvarum involvement of short- and long-term regulation . J Gen Microbiol. 129:1983;43-49.
5. Von Meyenburg H.K. Energetics of the budding cycle of Saccharomyces cerevisiae during glucose-limited aerobic growth. Arch Mikrobiol. 66:1969;289-303.
6. Verduyn C. Physiology of yeasts in relation to growth yields. Ant van Leeuwenhoek. 60:1991;325-353.
7. Beudeker R.F., van Dam H.W., van der Plaat J.B., Vellega K. Developments in bakers' yeast production. Verachtert H., De Mot R. Yeast biotechnology and biocatalysis. 1990;103-146 Marcel Dekker, New York.
8. Benítez B, Gasent-Ramirez JM, Castrejón F, Codón AC. Development of new strains for the food industry. Biotechnol Prog 1996:12;149-63.
9. Clifton D., Weinstock S.B., Fraenkel D.G. Glycolysis mutants in Saccharomyces cerevisiae. Genetics. 88:1977;1-11.
10. Dombek K.M., Ingram L.O. Ethanol production during batch fermentation with Saccharomyces cerevisiae changes in glycolytic enzymes and internal pH . Appl Environ Microbiol. 53:1987;1286-1291.
11. Schaaff I., Heinisch J., Zimmermann F.K. Overproduction of glycolytic enzymes in yeast. Yeast. 5:1989;285-290.
12. van Dijken J.P., van den Bosch E., Hermans J.J., de Miranda L.R., Scheffers W.A. Alcoholic fermentation by 'non-fermenting' yeasts. Yeast. 2:1986;123-127.
13. van Hoek P., Flikweert M.T., van der Aart Q.J.M., Yde Steensma H., van Dijken J.P., Pronk J.T. Effects of pyruvate decarboxylase overproduction on flux distribution at the pyruvate branchpoint in Saccharomyces cerevisiae. Appl Env Microbiol. 64:1998;2133-2140.
14. van Hoek P., van Dijken J.P., Pronk J.T. Effect of specific growth rate on fermentative capacity of bakers' yeast. Appl Env Microbiol. 64:1998;4226-4233.
15. Verduyn C., Postma E., Scheffers W.A., van Dijken J.P. Effect of benzoic acid on metabolic fluxes in yeasts a continuous study on the regulation of respiration and alcoholic fermentation . Yeast. 8:1992;501-517.
16. Verduyn C., Postma E., Scheffers W.A., van Dijken J.P. Physiology of Saccharomyces cerevisiae in anaerobic glucose-limited chemostat cultures. J Gen Microbiol. 136:1990;395-403.
17. Noorman H.J., Baksteen J., Heijnen J.J., Luyben KChAM. The bioreactor overflow device an undesired selective separator in continuous cultures? J Gen Microbial. 13:1991;2171-2177.
18. Sherman F., Fink G.R., Hicks J.B. Laboratory course manual for methods in yeast gene genetics. 1986;Cold Spring Harbor Laboratory, Cold Spring Harbor, New York.
19. Schulze U. Anaerobic physiology of Saccharomyces cerevisiae. Technical University of Denmark, Lyngby, Denmark, 1995. Thesis.
20. Verduyn C. Energetic aspects of metabolic fluxes in yeast. Delft University of Technology, Delft, The Netherlands, 1992. Thesis.
21. van Urk H., Mak P.R., Scheffers W.A., van Dijken J.P. Metabolic responses of Saccharomyces cerevisiae CBS 8066 and Candida utilis CBS 621 upon transition from glucose limitation to glucose excess. Yeast. 4:1988;283-291.
22. Weusthuis R.A., Luttik M.A.H., Scheffers W.A., van Dijken J.P., Pronk J.T. Is the Kluyver effect in yeast caused by product inhibition? Microbiology. 140:1994;1723-1729.
23. Verduyn C., van Dijken J.P., Scheffers W.A. Colorimetric alcohol assays with alcohol oxidase. J Microbiol Meth. 2:1984;15-25.
24. Postma E., Scheffers W.A., van Dijken J.P. Adaptation of the kinetics of glucose transport to environmental conditions in the yeast Candida utilis CBS 621 a continuous-culture study . J Gen Microbiol. 134:1988;1109-1116.
25. Bergmeyer HU. Methods of enzymatic analysis, 2nd ed., Vol. 1. New York: Academic Press, 1974.
26. de Jong-Gubbels P., Vanrolleghem P., Heijnen J.J., van Dijken J.P., Pronk J.T. Regulation of carbon metabolism in chemostat cultures of Saccharomyces cerevisiae grown on mixtures of glucose and ethanol. Yeast. 11:1995;407-418.
27. van Dijken J.P., Harder W., Beardsmore A.J., Quayle J.R. Dihydroxyacetone an intermediate in the assimilation of methanol by yeasts? FEMS Microbiol Lett. 4:1978;97-102.
28. Postma E., Verduyn C., Scheffers W.A., van Dijken J.P. Enzymic analysis of the Crabtree effect in glucose-limited chemostat cultures of Saccharomyces cerevisiae. Appl Env Microbiol. 53:1989;468-477.
29. Verduyn C., Postma E., Scheffers W.A., van Dijken J.P. Physiology of Saccharomyces cerevisiae in anaerobic glucose-limited chemostat cultures. J Gen Microbiol. 136:1990;395-403.
30. Fiechter A., Fuhrmann G.F., Käppeli O. Regulation of glucose metabolism in growing yeast cells. Adv Microb Physiol. 22:1981;123-183.
31. Verduyn C., Stouthamer A.H., Scheffers W.A., van Dijken J.P. A theoretical evaluation of growth yields of yeasts. Ant van Leeuwenhoek. 59:1991;49-63.
32. Kell D.B., Westerhoff H.V. Metabolic control theory its role in microbiology and biotechnology . FEMS Microbial Rev. 39:1986;305-320.
33. Walsh K., Koshland D.E. Characterization of rate-controlling steps in vivo by use of an adjustable expression vector. Proc Natl Acad Sci. 82:1985;3577-3581.
34. Poolman B., Bosman B., Kiers J., Konings W.N. Control of glycolysis by glyceraldehyde-3-phosphate dehydrogenase in Streptococcus cremoris and Streptococcus lactis. J Bacteriol. 169:1987;5887-5890.
35. Trivedi N.B., Jacobson G.K., Tesch W. Bakers' yeast. CRC Crit Rev Biotechnol. 4:1986;75-109.
36. van Hoek P, de Hulster E, van Dijken JP, Pronk JT. Biotechnol Bioeng. In press.
37. Kell D.B., Westerhoff H.V. Metabolic control theory its role in microbiology and biotechnology . FEMS Microbiol Rev. 39:1986;305-320.
38. Niederberger P., Prasad R., Miozzari G., Kacser H. A strategy for increasing an in vivo flux by genetic manipulations. The tryptophan system of yeast. Biochem J. 287:1992;473-479.
39. Lagunas R., Dominguez C., Busturia A., Sáez M.J. Mechanisms of appearance of the Pasteur effect in Saccharomyces cerevisiae inactivation of sugar transport system . J Bacteriol. 152:1982;19-25.
40. Oehlen L.J.W.M., Scholte M.E., de Koning W., van Dam K. Decrease in glycolytic flux in Saccharomyces cerevisiae cdc35-1 cells at restrictive temperature correlates with a decrease in glucose transport. Microbiol. 140:1994;1891-1898.
41. Diderich J.A., Schepper M., van Hoek P., Luttik M.A.H., van Dijken J.P., Pronk J.T., Klaassen P., Boelens H.F.M., Teixeira de Mattos M.J., van Dam K., Kruckeberg A.L. Glucose uptake kinetics and transcription of HXT genes in chemostat cultures of Saccharomyces cerevisiae. J Biol Chem. 274:1999;15350-15359.
42. Osinga KA, Buedeker RF, van der Plaat JB, de Hollander JA. New yeast strains providing for an enhanced rate of the fermentation of sugars. A process to obtain such yeasts and the use of these yeasts. 1986, Eur Patent Appl 0 306 107.
43. Navas M.A., Cerdán S., Gancedo J.M. Futile cycles in Saccharomyces cerevisiae strains expressing gluconeogenic enzymes during growth on glucose. Proc Natl Acad Sci. 90:1993;1290-1294.
44. Lowry R.H., Rosebrough N.J., Farr A.L., Randall R.J. Protein measurement with the folin phenol reagent. J Biol Chem. 193:1951;265-275.