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Volumn 4, Issue 7, 2011, Pages 637-643

Role of leptin and its receptors in the pathogenesis of thyroid cancer

Author keywords

Leptin; Leptin receptors; Papillary thyroid carcinoma; Sinaling pathways

Indexed keywords

LEPTIN; LEPTIN RECEPTOR; LEPTIN RECEPTOR, HUMAN;

EID: 81355139437     PISSN: None     EISSN: 19362625     Source Type: Journal    
DOI: None     Document Type: Review
Times cited : (26)

References (56)
  • 1
    • 0036963628 scopus 로고    scopus 로고
    • Leptin-from a signal of adiposity to a hormonal mediator in peripheral tissues
    • Baratta M. Leptin-from a signal of adiposity to a hormonal mediator in peripheral tissues. Med Sci Monit 2002; 8: RA282-RA292.
    • (2002) Med Sci Monit , vol.8
    • Baratta, M.1
  • 9
    • 2342444310 scopus 로고    scopus 로고
    • Leptin receptor signaling and the regulation of mammalian physiology
    • Myers MG Jr. Leptin receptor signaling and the regulation of mammalian physiology, Rec Prog Horn Res 2004; 59: 287-304.
    • (2004) Rec Prog Horn Res , vol.59 , pp. 287-304
    • Myers Jr., M.G.1
  • 11
    • 0031436148 scopus 로고    scopus 로고
    • Divergent signaling capacities of the long and short isoforms of the leptin receptor
    • Bjorbaek C, Uotani S, da Silva, B and Flier JS. Divergent signaling capacities of the long and short isoforms of the leptin receptor. J Biol Chem 1997; 272: 32686-32695.
    • (1997) J Biol Chem , vol.272 , pp. 32686-32695
    • Bjorbaek, C.1    Uotani, S.2    da Silva, B.3    Flier, J.S.4
  • 13
    • 0036219070 scopus 로고    scopus 로고
    • Identification of the critical sequence elements in the cytoplasmic domain of leptin receptor isoforms required for Janus kinase/signal transducer and activator of transcription activation by receptor heterodimers
    • Bahrenberg G, Behrmann I, Barthel A, Hekerman P, Heinrich PC, Joost HG and Becker W. Identification of the critical sequence elements in the cytoplasmic domain of leptin receptor isoforms required for Janus kinase/signal transducer and activator of transcription activation by receptor heterodimers. Mol Endocrinol 2002; 16: 859-872.
    • (2002) Mol Endocrinol , vol.16 , pp. 859-872
    • Bahrenberg, G.1    Behrmann, I.2    Barthel, A.3    Hekerman, P.4    Heinrich, P.C.5    Joost, H.G.6    Becker, W.7
  • 14
    • 56049083633 scopus 로고    scopus 로고
    • Leptin promotes motility and invasiveness in human colon cancer cells by activating multiple signal-transduction pathways
    • Jaffe T and Schwartz B. Leptin promotes motility and invasiveness in human colon cancer cells by activating multiple signal-transduction pathways. Int J Cancer 2008; 123: 2543-2556.
    • (2008) Int J Cancer , vol.123 , pp. 2543-2556
    • Jaffe, T.1    Schwartz, B.2
  • 15
    • 57649137956 scopus 로고    scopus 로고
    • Leptin stimulates both JAK2-dependent and JAK2-independent signaling pathways
    • Jiang L, Li Z and Rui L. Leptin stimulates both JAK2-dependent and JAK2-independent signaling pathways. J Biol Chem 2008; 283: 28066-28073.
    • (2008) J Biol Chem , vol.283 , pp. 28066-28073
    • Jiang, L.1    Li, Z.2    Rui, L.3
  • 16
    • 0034640508 scopus 로고    scopus 로고
    • Activation of downstream signals by the long form of the leptin receptor
    • Banks AS, Davis SM, Bates SH and Myers MG Jr. Activation of downstream signals by the long form of the leptin receptor. J Biol Chem 2000; 275: 14563-14572.
    • (2000) J Biol Chem , vol.275 , pp. 14563-14572
    • Banks, A.S.1    Davis, S.M.2    Bates, S.H.3    Myers Jr., M.G.4
  • 18
    • 0031761827 scopus 로고    scopus 로고
    • Functional properties of leptin receptor isoforms containing the gln-->pro extracellular domain mutation of the fatty rat
    • da Silva BA, Bjørbaek C, Uotani S and Flier JS. Functional properties of leptin receptor isoforms containing the gln-->pro extracellular domain mutation of the fatty rat. Endocrinology 1998; 39: 3681-3690.
    • (1998) Endocrinology , vol.39 , pp. 3681-3690
    • da Silva, B.A.1    Bjørbaek, C.2    Uotani, S.3    Flier, J.S.4
  • 19
    • 0031436148 scopus 로고    scopus 로고
    • Divergent signaling capacities of the long and short isoforms of the leptin receptor
    • Bjørbaek C, Uotani S, da Silva B and Flier JS. Divergent signaling capacities of the long and short isoforms of the leptin receptor. J Biol Chem 1997; 272: 32686-32695.
    • (1997) J Biol Chem , vol.272 , pp. 32686-32695
    • Bjørbaek, C.1    Uotani, S.2    da Silva, B.3    Flier, J.S.4
  • 21
    • 33847369824 scopus 로고    scopus 로고
    • The antiapoptotic and growth stimulatory actions of leptin in human colon cancer cells involves activation of JNK mitogen activated protein kinase, JAK2 and PI3 kinase/AKT
    • Ogunwobi OO and Beales IL. The antiapoptotic and growth stimulatory actions of leptin in human colon cancer cells involves activation of JNK mitogen activated protein kinase, JAK2 and PI3 kinase/AKT. Int J Colorectal Dis 2007; 22: 401-409.
    • (2007) Int J Colorectal Dis , vol.22 , pp. 401-409
    • Ogunwobi, O.O.1    Beales, I.L.2
  • 22
    • 34047250349 scopus 로고    scopus 로고
    • Concomitant activation of the JAK/STAT, PI3K/AKT, and ERK signaling is involved in leptin-mediated promotion of invasion and migration of hepatocellular carcinoma cells
    • Saxena NK, Sharma D, Ding X, Lin S, Marra F, Merlin D and Anania FA. Concomitant activation of the JAK/STAT, PI3K/AKT, and ERK signaling is involved in leptin-mediated promotion of invasion and migration of hepatocellular carcinoma cells. Cancer Res 2007; 67: 2497-2507.
    • (2007) Cancer Res , vol.67 , pp. 2497-2507
    • Saxena, N.K.1    Sharma, D.2    Ding, X.3    Lin, S.4    Marra, F.5    Merlin, D.6    Anania, F.A.7
  • 23
    • 33745108419 scopus 로고    scopus 로고
    • Leptin promotes the proliferative response and invasiveness in human endometrial cancer cells by activating multiple signaltransduction pathways
    • Sharma D, Saxena NK, Vertino PM and Anania FA. Leptin promotes the proliferative response and invasiveness in human endometrial cancer cells by activating multiple signaltransduction pathways. Endocr Relat Cancer 2006; 13: 629-640.
    • (2006) Endocr Relat Cancer , vol.13 , pp. 629-640
    • Sharma, D.1    Saxena, N.K.2    Vertino, P.M.3    Anania, F.A.4
  • 24
    • 0028909206 scopus 로고
    • Regulation of phosphatidylinositol 3'-kinase by tyrosyl phosphoproteins. Full activation requires occupancy of both SH2 domains in the 85-kDa regulatory subunit
    • Rordorf-Nikolic T, Van Horn DJ, Chen D, White MF, Backer JM. Regulation of phosphatidylinositol 3'-kinase by tyrosyl phosphoproteins. Full activation requires occupancy of both SH2 domains in the 85-kDa regulatory subunit. J Biol Chem 1995; 270: 3662-3666.
    • (1995) J Biol Chem , vol.270 , pp. 3662-3666
    • Rordorf-Nikolic, T.1    Van Horn, D.J.2    Chen, D.3    White, M.F.4    Backer, J.M.5
  • 25
    • 0038578823 scopus 로고    scopus 로고
    • The PI-3 kinase/AKT pathway and T cell activation: pleiotropic pathways downstream of PIP3
    • Kane LP and Weiss A. The PI-3 kinase/AKT pathway and T cell activation: pleiotropic pathways downstream of PIP3. Immunol Rev 2003; 192: 7-20.
    • (2003) Immunol Rev , vol.192 , pp. 7-20
    • Kane, L.P.1    Weiss, A.2
  • 26
    • 0035853833 scopus 로고    scopus 로고
    • AKT and Bcl-xL promote growth factor-independent survival through distinct effects on mitochondrial physiology
    • Plas DR, Talapatra S, Edinger AL, Rathmell JC and Thompson CB. AKT and Bcl-xL promote growth factor-independent survival through distinct effects on mitochondrial physiology. J Biol Chem 2001; 276: 12041-12048.
    • (2001) J Biol Chem , vol.276 , pp. 12041-12048
    • Plas, D.R.1    Talapatra, S.2    Edinger, A.L.3    Rathmell, J.C.4    Thompson, C.B.5
  • 28
    • 14044265068 scopus 로고    scopus 로고
    • Stress-responsive protein kinases in redox-regulated apoptosis signaling
    • Matsuzawa A and Ichijo H. Stress-responsive protein kinases in redox-regulated apoptosis signaling. Antioxid Redox Signal 2005; 7: 472-481.
    • (2005) Antioxid Redox Signal , vol.7 , pp. 472-481
    • Matsuzawa, A.1    Ichijo, H.2
  • 30
    • 1842333237 scopus 로고    scopus 로고
    • Interleukin-3-induced phosphorylation of BAD through the protein kinase AKT
    • del Peso L, Gonzalez-Garcia M, Page C, Herrera R and Nunez G. Interleukin-3-induced phosphorylation of BAD through the protein kinase AKT. Science 1997; 278: 687-689.
    • (1997) Science , vol.278 , pp. 687-689
    • del Peso, L.1    Gonzalez-Garcia, M.2    Page, C.3    Herrera, R.4    Nunez, G.5
  • 31
    • 0030584079 scopus 로고    scopus 로고
    • Apoptosis meets signal transduction: elimination of a BAD influence
    • Gajewski TF and Thompson CB. Apoptosis meets signal transduction: elimination of a BAD influence. Cell 1996; 87: 589-592.
    • (1996) Cell , vol.87 , pp. 589-592
    • Gajewski, T.F.1    Thompson, C.B.2
  • 33
    • 0029587224 scopus 로고
    • Inhibition of glycogen synthase kinase-3 by insulin mediated by protein kinase B
    • Cross DA, Alessi DR, Cohen P, Andjelkovich M and Hemmings BA. Inhibition of glycogen synthase kinase-3 by insulin mediated by protein kinase B. Nature 1995; 378: 785-789.
    • (1995) Nature , vol.378 , pp. 785-789
    • Cross, D.A.1    Alessi, D.R.2    Cohen, P.3    Andjelkovich, M.4    Hemmings, B.A.5
  • 34
    • 24944480788 scopus 로고    scopus 로고
    • The AKT-mTOR tango and its relevance to cancer
    • Hay N. The AKT-mTOR tango and its relevance to cancer. Cancer Cell 2005; 8: 179-183.
    • (2005) Cancer Cell , vol.8 , pp. 179-183
    • Hay, N.1
  • 36
    • 77951699992 scopus 로고    scopus 로고
    • Differential roles of leptin in regulating cell migration in thyroid cancer cells
    • Cheng SP, Yin PH, Chang YC, Lee CH, Huang SY and Chi CW. Differential roles of leptin in regulating cell migration in thyroid cancer cells. Oncol Rep 2010; 23: 1721-1727.
    • (2010) Oncol Rep , vol.23 , pp. 1721-1727
    • Cheng, S.P.1    Yin, P.H.2    Chang, Y.C.3    Lee, C.H.4    Huang, S.Y.5    Chi, C.W.6
  • 37
    • 0035369623 scopus 로고    scopus 로고
    • Transcription-dependent and -independent control of neuronal survival by the PI3K-AKT signaling pathway
    • Brunet A, Datta SR and Greenberg ME. Transcription-dependent and -independent control of neuronal survival by the PI3K-AKT signaling pathway. Curr Opin Neurobiol 2001; 11: 297-305.
    • (2001) Curr Opin Neurobiol , vol.11 , pp. 297-305
    • Brunet, A.1    Datta, S.R.2    Greenberg, M.E.3
  • 38
    • 0034644712 scopus 로고    scopus 로고
    • XIAP regulates DNA damageinduced apoptosis downstream of caspase-9 cleavage
    • Datta R, Oki E, Endo K, Biedermann V, Ren J and Kufe D. XIAP regulates DNA damageinduced apoptosis downstream of caspase-9 cleavage. J Biol Chem 2000; 275: 31733-31738.
    • (2000) J Biol Chem , vol.275 , pp. 31733-31738
    • Datta, R.1    Oki, E.2    Endo, K.3    Biedermann, V.4    Ren, J.5    Kufe, D.6
  • 41
    • 59349121844 scopus 로고    scopus 로고
    • Leptin expression correlates with favorable clinicopathologic phenotype and better prognosis in colorectal adenocarcinoma
    • Paik SS, Jang SM, Jang KS, Lee KH, Choi D and Jang SJ. Leptin expression correlates with favorable clinicopathologic phenotype and better prognosis in colorectal adenocarcinoma. Ann Surg Oncol 2009; 16: 297-303.
    • (2009) Ann Surg Oncol , vol.16 , pp. 297-303
    • Paik, S.S.1    Jang, S.M.2    Jang, K.S.3    Lee, K.H.4    Choi, D.5    Jang, S.J.6
  • 42
    • 70449377000 scopus 로고    scopus 로고
    • Overexpression of leptin receptor predicts an unfavorable outcome in Middle Eastern ovarian cancer
    • Uddin S, Bu R, Ahmed M, Abubaker J, Al-Dayel F, Bavi P and Al-Kuraya KS. Overexpression of leptin receptor predicts an unfavorable outcome in Middle Eastern ovarian cancer. Mol Cancer 2009; 8: 74.
    • (2009) Mol Cancer , vol.8 , pp. 74
    • Uddin, S.1    Bu, R.2    Ahmed, M.3    Abubaker, J.4    Al-Dayel, F.5    Bavi, P.6    Al-Kuraya, K.S.7
  • 43
    • 12244271468 scopus 로고    scopus 로고
    • Expression of leptin receptors and potential effects of leptin on the cell growth and activation of mitogen-activated protein kinases in ovarian cancer cells
    • Choi JH, Park SH, Leung PC and Choi KC. Expression of leptin receptors and potential effects of leptin on the cell growth and activation of mitogen-activated protein kinases in ovarian cancer cells. J Clin Endocrinol Metab 2005; 90: 207-210.
    • (2005) J Clin Endocrinol Metab , vol.90 , pp. 207-210
    • Choi, J.H.1    Park, S.H.2    Leung, P.C.3    Choi, K.C.4
  • 44
    • 77954096916 scopus 로고    scopus 로고
    • Leptin receptor expression and its association with PI3K/AKT signaling pathway in diffuse large Bcell lymphoma
    • Uddin S, Bu R, Ahmed M, Hussain AR, Ajarim D, Al-Dayel F, Bavi P and Al-kuraya KS. Leptin receptor expression and its association with PI3K/AKT signaling pathway in diffuse large Bcell lymphoma. Leuk Lymphoma 2010; 51: 1305-1314.
    • (2010) Leuk Lymphoma , vol.51 , pp. 1305-1314
    • Uddin, S.1    Bu, R.2    Ahmed, M.3    Hussain, A.R.4    Ajarim, D.5    Al-Dayel, F.6    Bavi, P.7    Al-kuraya, K.S.8
  • 47
    • 33646515095 scopus 로고    scopus 로고
    • Effects of thyroid hormones on serum levels of adipokines as studied in patients with differentiated thyroid carcinoma during thyroxine withdrawal
    • Botella-Carretero JI, Alvarez-Blasco F, Sancho J and Escobar-Morreale HF. Effects of thyroid hormones on serum levels of adipokines as studied in patients with differentiated thyroid carcinoma during thyroxine withdrawal. Thyroid 2006; 16: 397-402.
    • (2006) Thyroid , vol.16 , pp. 397-402
    • Botella-Carretero, J.I.1    Alvarez-Blasco, F.2    Sancho, J.3    Escobar-Morreale, H.F.4
  • 49
    • 77952320543 scopus 로고    scopus 로고
    • Clinicopathologic significance of leptin and leptin receptor expressions in papillary thyroid carcinoma
    • Cheng SP, Chi CW, Tzen CY, Yang TL, Lee JJ, Liu TP and Liu CL. Clinicopathologic significance of leptin and leptin receptor expressions in papillary thyroid carcinoma. Surgery 2010; 147: 847-853.
    • (2010) Surgery , vol.147 , pp. 847-853
    • Cheng, S.P.1    Chi, C.W.2    Tzen, C.Y.3    Yang, T.L.4    Lee, J.J.5    Liu, T.P.6    Liu, C.L.7
  • 51
    • 54349109378 scopus 로고    scopus 로고
    • High rate of persistent/recurrent disease among patients with differentiated thyroid cancer in Saudi Arabia: factors affecting nonremission
    • Raef H, Alfadhli E, Al-Hajjaj A, Malabu UH, Al-Sobhi S, Rifai A and Al Nuaim A. High rate of persistent/recurrent disease among patients with differentiated thyroid cancer in Saudi Arabia: factors affecting nonremission. Ann Saudi Med 2008; 28: 277-281.
    • (2008) Ann Saudi Med , vol.28 , pp. 277-281
    • Raef, H.1    Alfadhli, E.2    Al-Hajjaj, A.3    Malabu, U.H.4    Al-Sobhi, S.5    Rifai, A.6    Al Nuaim, A.7
  • 52
    • 6344243617 scopus 로고    scopus 로고
    • SH2-B promotes insulin receptor substrate 1 (IRS1)-and IRS2-mediated activation of the phosphatidylinositol 3-kinase pathway in response to leptin
    • Duan C, Li M and Rui L. SH2-B promotes insulin receptor substrate 1 (IRS1)-and IRS2-mediated activation of the phosphatidylinositol 3-kinase pathway in response to leptin. J Biol Chem 2004; 279: 43684-43691.
    • (2004) J Biol Chem , vol.279 , pp. 43684-43691
    • Duan, C.1    Li, M.2    Rui, L.3
  • 56
    • 0035266318 scopus 로고    scopus 로고
    • XIAP regulates AKT activity and caspase-3-dependent cleavage during cisplatin-induced apoptosis in human ovarian epithelial cancer cells
    • Asselin E, Mills GB and Tsang BK. XIAP regulates AKT activity and caspase-3-dependent cleavage during cisplatin-induced apoptosis in human ovarian epithelial cancer cells. Cancer Res 2001; 61: 1862-1868.
    • (2001) Cancer Res , vol.61 , pp. 1862-1868
    • Asselin, E.1    Mills, G.B.2    Tsang, B.K.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.