Nanoparticle mediated delivery of pure P53 supercoiled plasmid DNA for gene therapy

Journal of Controlled Release

Volumn 156, Issue 2, 2011, Pages 212-222

  Gaspar, Vítor M ^a   Correia, Ilídio J ^a   Sousa, Ângela ^a   Silva, Filomena ^a   Paquete, Catarina M ^b   Queiroz, João A ^a   Sousa, Fani ^a  

^a UNIVERSITY OF BEIRA INTERIOR   (Portugal)

^b INSTITUTO DE TECNOLOGIA QUÍMICA E BIOLÓGICA   (Portugal)

Author keywords

Gene therapy; Nanoparticles; p53 Tumor suppressor; Supercoiled plasmid DNA

Indexed keywords

CHITOSAN NANOPARTICLES; CHROMATOGRAPHIC MATRIX; CLINICAL APPLICATION; ENCAPSULATION EFFICIENCY; EXPRESSION LEVELS; EXPRESSION VECTORS; GENE DELIVERY; GENE REPLACEMENT; HIGH PURITY; IN-VITRO; IONOTROPIC GELATION; ISOFORMS; NONVIRAL; P53 PROTEIN; P53 TUMOR SUPPRESSOR; PARTICLE SYNTHESIS; PLASMID DNA; PLASMID DNA (PDNA); SPECIFIC RECOGNITION; STRUCTURAL STABILITIES; SUPERCOILED; TRANSFECTED CELLS; TRANSFECTION EFFICIENCY; TRANSGENE EXPRESSION; TUMOR SUPPRESSORS;

AMINO ACIDS; BIOMOLECULES; COAGULATION; DISEASES; DNA; ENCAPSULATION; GELATION; GENE EXPRESSION; GENE TRANSFER; NANOPARTICLES; STABILITY; TUMORS;

GENE THERAPY;

CHITOSAN; PLASMID DNA; PROTEIN P53;

AFFINITY CHROMATOGRAPHY; ANIMAL CELL; APOPTOSIS; ARTICLE; CANCER CELL; DNA SUPERCOILING; DRUG DELIVERY SYSTEM; GENE THERAPY; HUMAN; HUMAN CELL; IN VITRO STUDY; NONHUMAN; PARTICLE SIZE; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT; TUMOR SUPPRESSOR GENE;

ANIMALS; CELL LINE, TUMOR; CELLS, CULTURED; DNA, SUPERHELICAL; GENE EXPRESSION REGULATION, NEOPLASTIC; GENE THERAPY; HUMANS; NANOPARTICLES; NEOPLASMS; PLASMIDS; RATS; TRANSFECTION; TUMOR SUPPRESSOR PROTEIN P53;

EID: 81255211172     PISSN: 01683659     EISSN: 18734995     Source Type: Journal    
DOI: 10.1016/j.jconrel.2011.08.007     Document Type: Article

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