Gene therapy: A pharmacokinetic/pharmacodynamic modelling overview

Pharmaceutical Research

Volumn 27, Issue 8, 2010, Pages 1487-1497

  Parra Guillén, Zinnia P ^a   González Aseguinolaza, Gloria ^b   Berraondo, Pedro ^b   Trocóniz, Iñaki F ^a  

^a UNIVERSITY OF NAVARRA   (Spain)

^b UNIVERSITY OF NAVARRA   (Spain)

Author keywords

computational modelling; gene therapy; pharmacokinetic pharmacodynamic modelling

Indexed keywords

ADENOVIRUS VECTOR; CHLORAMPHENICOL ACETYLTRANSFERASE; INTERLEUKIN 2; LIPOSOME; PLASMID DNA; RETROVIRUS VECTOR;

AREA UNDER THE CURVE; CANCER GENE THERAPY; DISTRIBUTION VOLUME; DRUG CLEARANCE; DRUG HALF LIFE; GENE EXPRESSION; GENE THERAPY; HUMAN; HYDRODYNAMICS BASED TRANSFECTION; INTRACELLULAR TRANSPORT; MATHEMATICAL MODEL; MAXIMUM PLASMA CONCENTRATION; MEAN RESIDENCE TIME; MICHAELIS MENTEN KINETICS; NONHUMAN; NONVIRAL GENE DELIVERY SYSTEM; PLASMA CLEARANCE; PLASMA HALF LIFE; PRIORITY JOURNAL; REVIEW; TIME TO MAXIMUM PLASMA CONCENTRATION; TISSUE DISTRIBUTION; TRANSGENE; VIRAL GENE DELIVERY SYSTEM; BIOLOGICAL MODEL; GENE VECTOR;

GENE THERAPY; GENETIC VECTORS; HUMANS; MODELS, BIOLOGICAL; GENETIC THERAPY;

EID: 77955469770     PISSN: 07248741     EISSN: 1573904X     Source Type: Journal    
DOI: 10.1007/s11095-010-0136-4     Document Type: Review

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