DNA tattoo vaccination: Effect on plasmid purity and transfection efficiency of different topoisoforms

Journal of Controlled Release

Volumn 139, Issue 2, 2009, Pages 153-159

  Quaak, S G L ^a   den Berg, J H van ^a,b   Oosterhuis, K ^b   Beijnen, J H ^a,c   Haanen, J B A G ^a   Nuijen, B ^a  

^a NETHERLANDS CANCER INSTITUTE   (Netherlands)

^b UTRECHT UNIVERSITY   (Netherlands)

^c UTRECHT UNIVERSITY   (Netherlands)

Author keywords

Antigen expression; DNA tattooing; DNA topology; ex vivo skin model; pDNA formulations

Indexed keywords

ANTIGEN EXPRESSION; DNA TOPOLOGY; EX VIVO SKIN MODEL; EX-VIVO; HUMAN SKIN; IMMUNE RESPONSE; IN-VITRO; MURINE MODEL; PDNA FORMULATIONS; PLASMID DNA (PDNA); POLYPLEXES; REGULATORY AUTHORITIES; SHELF LIFE; SKIN MODEL; SUPERCOILED; T-CELL RESPONSE; TRANSFECTION EFFICIENCY;

ANTIGENS; CELL MEMBRANES; DNA; GENES; LAWS AND LEGISLATION; SKIN; TOPOLOGY;

NUCLEIC ACIDS;

DNA VACCINE; PLASMID DNA;

ANIMAL CELL; ANIMAL EXPERIMENT; ANTIGEN EXPRESSION; ARTICLE; BIOLOGICAL ACTIVITY; CONTROLLED STUDY; DNA CONTENT; DNA DAMAGE; DNA DEGRADATION; DNA IMMUNIZATION; DNA SUPERCOILING; DRUG FORMULATION; DRUG POTENCY; DRUG PURITY; DRUG RELEASE; EX VIVO STUDY; FEMALE; GENETIC TRANSFECTION; HUMAN; HUMAN TISSUE; IMMUNE RESPONSE; IN VITRO STUDY; MOUSE; NONHUMAN; NORMAL HUMAN; PRIORITY JOURNAL; SHELF LIFE; SKIN; T LYMPHOCYTE; TATTOOING;

ANIMALS; ANTIGENS; DNA, SUPERHELICAL; FEMALE; GENE EXPRESSION; HUMANS; INJECTIONS, INTRADERMAL; MICE; MICE, INBRED C57BL; PLASMIDS; SKIN; TRANSFECTION; VACCINATION; VACCINES, DNA;

EID: 69949187556     PISSN: 01683659     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jconrel.2009.06.033     Document Type: Article

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