Nicotinic acids: Liver-targeted SCD inhibitors with preclinical anti-diabetic efficacy

Bioorganic and Medicinal Chemistry Letters

Volumn 21, Issue 24, 2011, Pages 7281-7286

  Powell, David A ^a   Black, W Cameron ^a   Bleasby, Kelly ^b   Chan, Chi Chung ^a   Deschenes, Denis ^a   Gagnon, Marc ^a   Gordon, Rob ^a   Guay, Jocelyne ^a   Guiral, Sebastien ^a   Hafey, Michael J ^b   Huang, Zheng ^a   Isabel, Elise ^a   Leblanc, Yves ^a   Styhler, Angela ^a   Xu, Li Jing ^a   Zhang, Lei ^a   Oballa, Renata M ^a  

^a MERCK FROSST CENTRE FOR THERAPEUTIC RESEARCH   (Canada)

^b MERCK RESEARCH LABORATORIES   (United States)

Author keywords

Liver targeted; Nicotinic acid; OATP; SCD; Stearoyl coenzyme A

Indexed keywords

ACYL COENZYME A DESATURASE; ACYL COENZYME A DESATURASE INHIBITOR; ANTIDIABETIC AGENT; NICOTINIC ACID DERIVATIVE; ORGANIC ANION TRANSPORTER 1; ORGANIC ANION TRANSPORTER 1B1; ORGANIC ANION TRANSPORTER 1B2; ORGANIC ANION TRANSPORTER 1B3; OXYGENASE INHIBITOR; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; CELL LINE; CELL STRAIN HEPG2; CONTROLLED STUDY; DRUG ACTIVITY; DRUG BLOOD LEVEL; DRUG EFFICACY; DRUG LIVER LEVEL; DRUG POTENCY; DRUG SCREENING; DRUG STRUCTURE; DRUG TARGETING; DRUG TISSUE LEVEL; GENETIC TRANSFECTION; GLUCOSE TOLERANCE TEST; HUMAN; HUMAN CELL; IC 50; LIQUID CHROMATOGRAPHY; LIVER; MALE; MASS SPECTROMETRY; MOLECULAR RECOGNITION; MOUSE; NONHUMAN; RAT; STRUCTURE ACTIVITY RELATION;

ADMINISTRATION, ORAL; ANIMALS; CELL LINE; DRUG EVALUATION, PRECLINICAL; ENZYME ACTIVATION; ENZYME INHIBITORS; HUMANS; HYPOGLYCEMIC AGENTS; LIVER; MICE; MICE, INBRED C57BL; NICOTINIC ACIDS; RATS; STEAROYL-COA DESATURASE; STRUCTURE-ACTIVITY RELATIONSHIP; TISSUE DISTRIBUTION;

EID: 81255199178     PISSN: 0960894X     EISSN: 14643405     Source Type: Journal    
DOI: 10.1016/j.bmcl.2011.10.040     Document Type: Article

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