Bicyclic heteroaryl inhibitors of stearoyl-CoA desaturase: From systemic to liver-targeting inhibitors

Bioorganic and Medicinal Chemistry Letters

Volumn 21, Issue 19, 2011, Pages 5692-5696

  Ramtohul, Yeeman K ^a   Powell, David ^a   Leclerc, Jean Philippe ^a   Leger, Serge ^a   Oballa, Renata ^a   Black, Cameron ^a   Isabel, Elise ^a   Li, Chun Sing ^a   Crane, Sheldon ^a   Robichaud, Joel ^a   Guay, Jocelyne ^a   Guiral, Sébastien ^a   Zhang, Lei ^a   Huang, Zheng ^a  

^a MERCK FROSST CENTRE FOR THERAPEUTIC RESEARCH   (Canada)

Author keywords

Desaturation index; Liver selective inhibitors; Mouse liver PD; SCD1 inhibitors; Stearoyl CoA

Indexed keywords

ACYL COENZYME A DESATURASE; ACYL COENZYME A DESATURASE INHIBITOR; ENZYME INHIBITOR; MF 152; THIAZOLE DERIVATIVE; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DRUG DISTRIBUTION; DRUG DOSE COMPARISON; DRUG POTENCY; DRUG STRUCTURE; DRUG SYNTHESIS; DRUG TARGETING; LIVER; MOUSE; NONHUMAN; TISSUE DISTRIBUTION;

AMIDES; ANIMALS; DRUG DESIGN; DRUG DISCOVERY; DRUG EVALUATION, PRECLINICAL; DRUG STABILITY; ENZYME INHIBITORS; LIVER; MICE; MICROSOMES, LIVER; MOLECULAR STRUCTURE; PIPERAZINES; RATS; STEAROYL-COA DESATURASE; STRUCTURE-ACTIVITY RELATIONSHIP; THIAZOLES;

RODENTIA;

EID: 80052555159     PISSN: 0960894X     EISSN: 14643405     Source Type: Journal    
DOI: 10.1016/j.bmcl.2011.08.037     Document Type: Article

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