Pharmacological inhibition of Stearoyl-CoA Desaturase 1 improves insulin sensitivity in insulin-resistant rat models

European Journal of Pharmacology

Volumn 618, Issue 1-3, 2009, Pages 28-36

  Issandou, Marc ^a   Bouillot, Anne ^a   Brusq, Jean Marie ^a   Forest, Marie Claire ^a   Grillot, Didier ^a   Guillard, Raphaelle ^a   Martin, Sandrine ^a   Michiels, Christelle ^a   Sulpice, Thierry ^b   Daugan, Alain ^a  

^a GLAXOSMITHKLINE   (France)

^b Prologue Biotech   (France)

Author keywords

Insulin resistance; SCD1 inhibitor

Indexed keywords

ACYL COENZYME A DESATURASE; ACYL COENZYME A DESATURASE 1; GLUCOSE; GSK 993; LIPID; OXYGENASE INHIBITOR; TRIACYLGLYCEROL; TYLOXAPOL; UNCLASSIFIED DRUG; VERY LOW DENSITY LIPOPROTEIN;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CELL STRAIN HEPG2; CONTROLLED STUDY; DRUG EFFICACY; DRUG MECHANISM; DRUG POTENCY; ENZYME INHIBITION; GLUCOSE CLAMP TECHNIQUE; GLUCOSE METABOLISM; GLUCOSE TOLERANCE; HUMAN; HUMAN CELL; INSULIN RESISTANCE; INSULIN SENSITIVITY; LIPID LIVER LEVEL; LIPID METABOLISM; LIPOGENESIS; LIVER CELL; LIVER MICROSOME; MUSCLE CELL; NONHUMAN; PRIORITY JOURNAL; RAT;

ANIMALS; CATTLE; CELL LINE, TUMOR; DIET; DISEASE MODELS, ANIMAL; DRUG EVALUATION, PRECLINICAL; ENZYME INHIBITORS; GLUCOSE; HUMANS; INSULIN; INSULIN RESISTANCE; ISOQUINOLINES; LIPID METABOLISM; LIVER; PYRAZOLES; RATS; STEAROYL-COA DESATURASE;

EID: 69249213918     PISSN: 00142999     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ejphar.2009.07.004     Document Type: Article

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