Orally bioavailable, liver-selective stearoyl-CoA desaturase (SCD) inhibitors

Bioorganic and Medicinal Chemistry Letters

Volumn 19, Issue 11, 2009, Pages 3050-3053

  Koltun, Dmitry O ^a   Vasilevich, Natalya I ^b   Parkhill, Eric Q ^a   Glushkov, Andrei I ^b   Zilbershtein, Timur M ^b   Mayboroda, Elena I ^b   Boze, Melanie A ^a   Cole, Andrew G ^c   Henderson, Ian ^c   Zautke, Nathan A ^a   Brunn, Sandra A ^a   Chu, Nancy ^a   Hao, Jia ^a   Mollova, Nevena ^a   Leung, Kwan ^a   Chisholm, Jeffrey W ^a   Zablocki, Jeff ^a  

^a CV THERAPEUTICS INC   (United States)

^b Asinex Ltd   (Russian Federation)

^c Ligand Pharmaceuticals Inc   (United States)

Author keywords

HEPG2 assay; Microsomal assay; Saturation index; Stearoyl CoA desaturase (SCD); Tissue distribution; Tissue partition

Indexed keywords

ACYL COENZYME A DESATURASE; CVT 11563; FATTY ACID; OXYGENASE INHIBITOR; SUCROSE; UNCLASSIFIED DRUG;

ADIPOSE TISSUE; ANIMAL EXPERIMENT; ANIMAL TISSUE; AREA UNDER THE CURVE; ARTICLE; CARBOHYDRATE INTAKE; CONTROLLED STUDY; DRUG ACTIVITY; DRUG BIOAVAILABILITY; DRUG DISTRIBUTION; DRUG HALF LIFE; DRUG PENETRATION; DRUG POTENCY; DRUG SELECTIVITY; DRUG STRUCTURE; GAS CHROMATOGRAPHY; HUMAN; HUMAN CELL; LIPID COMPOSITION; MALE; NONHUMAN; RAT;

ADMINISTRATION, ORAL; ANIMALS; BENZYL COMPOUNDS; CELL LINE, TUMOR; DIETARY CARBOHYDRATES; ENZYME INHIBITORS; HUMANS; MICROSOMES, LIVER; PYRIMIDINONES; RATS; RATS, SPRAGUE-DAWLEY; STEAROYL-COA DESATURASE; TISSUE DISTRIBUTION;

RATTUS;

EID: 65149089384     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2009.04.004     Document Type: Article

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