Analysis of a form of oxidative DNA damage, 8-hydroxy-2'-deoxyguanosine, as a marker of cellular oxidative stress during carcinogenesis

Mutation Research - Reviews in Mutation Research

Volumn 387, Issue 3, 1997, Pages 147-163

  Kasai, Hiroshi ^a  

^a UNIVERSITY OF OCCUPATIONAL AND ENVIRONMENTAL HEALTH   (Japan)

Author keywords

8 Hydroxy 2' deoxyguanosine; DNA damage; Oxygen radical

Indexed keywords

8 HYDROXYDEOXYGUANOSINE; MARKER;

CARCINOGENESIS; DNA DAMAGE; DNA DETERMINATION; DNA REPAIR; ELECTROCHEMICAL DETECTION; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HUMAN; IMMUNOASSAY; IN VITRO STUDY; LEUKOCYTE; NONHUMAN; OXIDATIVE STRESS; PRIORITY JOURNAL; REVIEW; URINALYSIS;

ANIMALIA;

EID: 0031469841     PISSN: 13835742     EISSN: None     Source Type: Journal    
DOI: 10.1016/S1383-5742(97)00035-5     Document Type: Article

References (195)

1. [1] H. Kasai, H. Hayami, Z. Yamaizumi, H. Saito, S. Nishimura, Detection and identification of mutagens and carcinogens as their adducts with guanosine derivatives, Nucl. Acids Res. 12 (1984) 2127-2136.
2. [2] H. Kasai, S. Nishimura, Hydroxylation of deoxyguanosine at the C-8 position by ascorbic acid and other reducing agents, Nucl. Acids. Res. 12 (1984) 2137-2145.
3. [3] H. Kasai, M. Nakayama, N. Toda, Z. Yamaizumi, J. Oikawa, S. Nishimura, Methylreductic acid and hydroxymethylreductic acid: oxygen radical forming agents in heated starch, Mutation Res. 214 (1989) 159-164.
4. [4] H. Kasai, S. Nishimura, Hydroxylation of guanine in nucleosides and DNA at the C-8 position by heated glucose and oxygen radical-forming agents, Environ. Health Perspect. 67 (1986) 111-116.
5. [5] H. Kasai, S. Nishimura, Hydroxylation of deoxyguanosine at the C-8 position by polyphenols and aminophenols in the presence of hydrogen peroxide and ferric ion, Gann 75 (1984) 565-566.
6. [6] H. Kasai, H. Tanooka, S. Nishimura, Formation of 8-hydroxyguanine residues in DNA by X-irradiation, Gann 75 (1984) 1037-1039.
7. [7] H. Kasai, M.-H. Chung, H. Kiyosawa, E. Ohtsuka, S. Nishimura, Formation of 8-hydroxydeoxyguanosine in DNA and carcinogenesis, in: O.F. Nygaard, A.C. Upton (Eds.), Anticarcinogenesis and Radiation Protection, vol. 2, Plenum Press, New York, 1991, pp. 141-144.
8. [8] H. Kasai, S. Nishimura, DNA damage induced by asbestos in the presence of hydrogen peroxide, Gann 75 (1984) 841-844.
9. [9] H. Kasai, S. Nishimura, Formation of 8-hydroxydeoxyguanosine in DNA by auto-oxidized unsaturated fatty acids, in: O. Hayaishi, E. Niki, M. Kondo, et al. (Eds.), Medical Biochemical and Chemical Aspects of Free Radicals, Elsevier Science B.V., Amsterdam, 1988, pp. 1021-1023.
10. [10] J.-W. Park, R.A. Floyd, Lipid peroxidation products mediate the formation of 8-hydroxydeoxyguanosine in DNA, Free Rad. Biol. Med. 12 (1992) 245-250.
11. [11] M. Nagashima, H. Kasai, J. Yokota, Y. Nagamachi, T. Ichinose, M. Sagai, Formation of an oxidative DNA damage, 8-hydroxydeoxyguanosine, in mouse lung DNA after intratracheal instillation of diesel exhaust particles and effects of high dietary fat and beta-carotene on this process, Carcinogenesis 16 (1995) 1441-1445.
12. [12] M. Dizdaroglu, Formation of an 8-hydroxyguanine moiety in deoxyribonucleic acid on γ-irradiation in aqueous solution, Biochemistry 24 (1985) 4476-4481.
13. [13] P. Leanderson, C. Tagesson, Cigarette smoke-induced DNA-damage: role of hydroquinone and catechol in the formation of the oxidative DNA-adduct, 8-hydroxydeoxyguanosine, Chem.-Biol. Interactions 75 (1990) 71-81.
14. [14] U.J. Nair, R.A. Floyd, J. Nair, V. Bussachini, M. Friesen, H. Bartsch, Formation of reactive oxygen species and of 8-hydroxydeoxyguanosine in DNA in vitro with betel quid ingredients, Chem. Biol. Interactions 63 (1987) 157-169.
15. [15] J.A. Rosier, C.H. Van Peteghem, Peroxidative in vitro metabolism of diethylstil-bestrol induces formation of 8-hydroxy-2′-deoxyguanosine, Carcinogenesis 10 (1989) 405-406.
16. [16] M. Shioya, K. Wakabayashi, K. Yamashita, M. Nagao, T. Sugimura, Formation of 8-hydroxydeoxyguanosine in DNA treated with fecapentene-12 and -14, Mutation Res. 225 (1989) 91-94.
17. [17] B. Epe, M. Haring, D. Ramaiah, H. Stopper, M. Abou-Elzahab, W. Adam, C.R. Saha-Moller, DNA damage induced by furocoumarin hydroperoxides plus UV (360 nm), Carcinogenesis 14 (1993) 2271-2276.
18. [18] R.A. Floyd, M.S. West, K.L. Eneff, W.E. Hogesett, D.T. Tingey, Hydroxyl free radical mediated formation of 8-hydroxyguanine in isolated DNA, Arch. Biochim. Biophys. 262 (1988) 266-272.
19. [19] K. S. Kasprzak, L. Hernandez, Enhancement of hydroxylation and deglycosylation of 2′-deoxyguanosine, Carcinogenesis 10 (1981) 405-406.
20. [20] H. Ohshima, A. Ono, A. Matsuda, S. Sawamura, M. Kuwabara, Reactions between hydroxy-radical-induced 7,8-dihydro-8-oxo-2′-deoxyguanosine precursor and the spin trap a-phenyl-N-tert-butylnitrone, J. Radiat. Res. 38 (1997) 15-25.
21. [21] R.A. Floyd, M.S. West, K.L. Eneff, J.E. Schneider, Methylene blue plus light mediates 8-hydroxyguanine formation in DNA, Arch. Biochim. Biophys. 273 (1989) 106-111.
22. 2 system, Chem. Pharm. Bull. 38 (1990) 3072-3075.
23. [23] H. Kasai, Z. Yamazumi, M. Berger, J. Cadet, Photosensitized formation of 7,8-dihydro-8-oxo-2′-deoxyguanosine in DNA by riboflavin: a non singlet oxygen mediated reaction, J. Am. Chem. Soc. 114 (1992) 9692-9694.
24. [24] K. Kohda, M. Tada, H. Kasai, S. Nishimura, Y. Kawazoe, Formation of 8-hydroxyguanine residues in cellular DNA exposed to the carcinogen 4-nitroquinoline 1-oxide, Biochim. Biophys. Res., Commun. 139 (1980) 626-632.
25. [25] B. Epe, D. Ballmaier, I. Roussyn, K. Briviba, H. Sies, Nucl. Acids Res. 24 (1996) 4105-4110.
26. [26] S. Shibutani, M. Takeshita, A.P. Grollman, Insertion of specific bases during DNA synthesis past the oxidation-damaged base 8-oxodG, Nature 349 (1991) 431-434.
27. [27] M.L. Wood, M. Dizdaroglu, E. Gajewski, J.M. Essigmann, Mechanistic studies of ionizing radiation and oxidative mutagenesis: genetic effects of a single 8-hydroxyguanine (7-hydro-8-oxoguanine) residue inserted at a unique site in a viral genome, Biochemistry 29 (1990) 7024-7032.
28. [28] K.C. Cheng, D.S. Cahill, H. Kasai, S. Nishimura, L.A. Loeb, 8-Hydroxyguanine, an abundant form of oxidative DNA damage, causes G → T and A → C substitutions, J. Biol. Chem. 267 (1992) 166-172.
29. [29] M. Moriya, C. Ou, V. Bodepudi, F. Johnson, M. Takeshita, A.P. Grollman, Site-specific mutagenesis using a gapped duplex vector: a study of translesion synthesis past 8-oxodeoxyguanosine in E. coli, Mutation Res. 254 (1991) 281-288.
30. [30] H. Kamiya, K. Miura, H. Ishikawa, H. Inoue, S. Nishimura, E. Ohtsuka, c-Ha-ras containing 8-hydroxyguanine at codon 12 induces point mutations at the modified and adjacent positions, Cancer Res. 52 (1992) 3483-3485.
31. [31] R.A. Floyd, J.J. Watson, P.K. Wong, D.H. Altmiller, R.C. Rickard, Hydroxyl free radical adduct of deoxyguanosine: sensitive detection and mechanisms of formation, Free Rad. Res. Commun. 1 (1986) 163-172.
32. [32] H. Kasai, S. Nishimura, Y. Kurokawa, Y. Hayashi, Oral administration of the renal carcinogen, potassium bromate, specifically produces 8-hydroxydeoxyguanosine in rat target organ DNA, Carcinogensis 8 (1987) 1959-1961.
33. [33] H. Kasai, Y. Okada, S. Nishimura, M.S. Rao, J.K. Reddy, Formation of 8-hydroxydeoxyguanosine in liver DNA of rats following long-term exposure to peroxisome proliferators, Cancer Res. 49 (1989) 2603-2605.
34. [34] E.S. Fiala, C. Conaway, J.F. Mathis, Oxidative DNA and RNA damage in the livers of Sprague-Dawley rats treated with the hepatocarcinogen 2-nitropropane, Cancer Res. 49 (1989) 5518-5522.
35. [35] A. Takagi, K. Sai, T. Umemura, R. Hasegawa, Y. Kurokawa, H. Kasai, Production of 8-hydroxydeoxyguanosine in rat liver DNA by oral administration of peroxisome proliferators, Igaku no Ayumi 149 (1989) 65-66.
36. [36] M.E. Hegi, D. Ulrich, P. Sagelsdorff, C. Richter, W.K. Lutz, No measurable increase in thymidine glylcol or 8-hydroxydeoxyguanosine in liver DNA of rats treated with nafenopin or choline-devoid low-methionine diet, Mutation Res. 238 (1990) 325-329.
37. [37] N.S. Hussain, C.C. Conaway, N. Guo, W. Asaad, E.S. Fiala, Oxidative DNA and RNA damage in rat liver due to acetoxime: similarity to effects of 2-nitropropane, Carcinogenesis 11 (1990) 1013-1016.
38. [38] T.M. Hagen, M.K. Shigenaga, J.W. Kitzler, B.N. Ames, Increased oxidative DNA damage following partial hepatectomy, Free Rad. Biol. Med. 1 (1990) 49.
39. [39] K.S. Kasprzak, K. Higinbotham, B.A. Diwan, A.O. Perantoni, J.M. Rice, Correlation of DNA base oxidation with the activation of K-ras oncogene in Nickel-induced renal tumors, Free Rad. Biol. Med. 1 (1990) 172.
40. [40] D. Nakae, H. Yoshiji, H. Maruyama, T. Kinugasa, A. Denda, Y. Konishi, Production of both 8-hydroxydeoxyguanosine in liver DNA and gamma-glutamyltransferase-positive hepatocellular lesions in rats given choline-deficienet, L-amino acid defined diet, Jpn. J. Cancer Res. 81 (1990) 1081-1084.
41. [41] T. Umemura, K. Sai, A. Takagi, R. Hasegawa, Y. Kurokawa, Oxidative DNA damage, lipid peroxidation and nephrotoxicity induced in the rat kidney after ferric nitrilotriacetate administration, Cancer Lett. 54 (1990) 95-100.
42. [42] A. Takagi, K. Sai, T. Umemura, R. Hasegawa, Y. Kurokawa, Relationship between hepatic peroxisome proliferation and 8-hydroxydeoxyguanosine formation in liver DNA of rats following long-term exposure to three peroxisome proliferators: di(2-ethylhexyl) phthalate, aluminium clofibrate and simfibrate, Cancer Lett. 53 (1990) 33-38.
43. [43] A. Takagi, K. Sai, T. Umemura, R. Hasegawa, Y. Kurokawa, Significant increase of 8-hydroxydeoxyguanosine in liver DNA of rats following short-term exposure to the peroxisome proliferators di(2-ethylhexyl)phthalate and di(2-ethylhexyl)adipate, Jpn. J. Cancer Res. 81 (1990) 213-215.
44. [44] K. Sai, A. Takagi, T. Umemura, R. Hasegawa, Y. Kurokawa, Relation of 8-hydroxydeoxyguanosine formation in rat kidney to lipid peroxidation, glutathione level and relative organ weight after a single administration of potassium bromate, Jpn. J. Cancer Res. 82 (1990) 165-169.
45. [45] G.G. Fraga, M.K. Shigenaga, J.W. Park, P. Degan, B.N. Ames, Oxidative damage to DNA during aging: 8-hydroxy-2́-deoxyguanosine in rat organ DNA and urine, Proc. Natl. Acad. Sci. USA 87 (1990) 4533-4537.
46. [46] A. Denda, K. Sai, Q. Tang, T. Tsujiuchi, M. Tsutsumi, T. Amanuma, Y. Murata, D. Nakae, H. Maruyama, Y. Kurokawa, Y. Konishi, Induction of 8-hydroxydeoxyguanosine but not initiation of carcinogenesis by redox enzyme modulations with or without menadione in rat liver, Carcinogenesis 12 (1991) 719-726.
47. [47] A. Takagi, K. Sai, T. Umemura, R. Hasegawa, Y. Kurokawa, Short-term exposure to the peroxisome proliferators, perfluorooctanoic acid and perfluorodecanoic acid, causes significant increase of 8-hydroxydeoxyguanosine in liver DNA of rats, Cancer Lett. 57 (1991) 55-60.
48. [48] C.C. Conaway, G. Nie, N.S. Hussain, E.S. Fiala, Comparison of oxidative damage to rat liver DNA and RNA by primary nitroalkanes, secondary nitroalkanes, cyclopentanone oxime, and related compounds, Cancer Res. 51 (1991) 3143-3147.
49. [49] M.H. Chung, H. Kasai, S. Nishimura, B.P. Yu, Protection of DNA damage by dietary restriction, Free Rad. Biol. Med. 12 (1992) 523-525.
50. [50] T. Yokozawa, K. Jujioka, H. Oura, Increase in kidney 8-hydroxydeoxyguanosine level with the progression of renal failure, Nephron 61 (1992) 236-237.
51. [51] M. Dahlhaus, K.E. Appel, N-nitrosodimethylamine, N-nitrosodiethylamine, and N-nitrosomorpholine fail to generate 8-hydroxy-2′-deoxyguanosine in liver DNA of male F344 rats, Mutation Res. 285 (1993) 295-302.
52. [52] M. Takasawa, M. Hayakawa, S. Sugiyama, K. Hattori, T. Ito, T. Ozawa, Age-associated damage in mitochondrial function in rat hearts, Exp. Gerontol. 28 (1993) 269-280.
53. [53] F. Yamamoto, H. Kasai, Y. Togashi, N. Takeichi, T. Hori, S. Nishimura, Elevated level of 8-hydroxydeoxyguanosine in DNA of liver, kidneys, and brain of long-evans cinnamon rats, Jpn. J. Cancer Res. 84 (1993) 508-511.
54. 3) carcinogenesis, J. Cancer Res. Clin. Oncol. 119 (1993) 463-469.
55. [55] S. Adachi, K. Kawamura, K. Takemoto, Oxidative damage of nuclear DNA in liver of rats exposed to psychological stress, Cancer Res. 53 (1993) 4153-4155.
56. [56] K. Umegaki, S. Ikegami, T. Ichikawa, Influence of dietary vitamin-E on the 8-hydroxydeoxyguanosine levels in rat liver DNA, J. Nut. Sci. Vitaminol. 39 (1993) 303-310.
57. [57] R.C. Cattley, S.E. Glover, Elevated 8-hydroxydeoxyguanosine in hepatic DNA of rats following exposure to peroxisome proliferators: relationship to carcinogenesis and nuclear localization, Carcinogenesis 14 (1993) 2495-2499.
58. 3, Cancer Lett. 74 (1993) 141-145.
59. [59] D. Haegele, A.P. Briggs, H.J. Thompson, Antioxidant status and dietary lipid unsaturation modulate oxidative DNA damage, Free Rad. Biol. Med. 16 (1993) 111-115.
60. [60] H.J. Ha, C. Kim, Y. Son, M.H. Chung, K.H. Kim, DNA damage in the kidneys of diabetic rats exhibiting microalbuminuria, Free Rad. Biol. Med. 16 (1994) 271-274.
61. [61] Y. Mizumoto, D. Nakae, H. Yoshiji, N. Andoh, K. Horiguchi, T. Endoh, E. Kobayashi, T. Tsujiuchi, N. Shimoji, A. Denda, T. Tsujii, M. Nagao, K. Wakabayashi, Y. Konishi, Inhibitory effects of 2-O-octadecylascorbic acid and other vitamin C and E derivatives on the induction of enzyme-altered putative preneoplastic lesions in the livers of rats fed a choline-deficient, L-amino acid-defined diet, Carcinogenesis 15 (1994) 241-246.
62. [62] S. Adachi, K. Kawamura, K. Takemoto, Increased susceptibility to oxidative DNA damage in regenerating liver, Carcinogenesis 15 (3) (1994) 539-543.
63. [63] S. Toyokuni, J.L. Sagripanti, Increased 8-hydroxydeoxyguanosine in kidney and liver of rats continuously exposed to copper, Toxicol. Appl. Pharmacol. 126 (1994) 91-97.
64. [64] K.S. Kasprzak, T.H. Zastawny, S.L. North, C.W. Riggs, B.A. Diwan, J.M. Rice, M. Dizdaroglu, Oxidative DNA base damage in renal, hepatic, and pulmonary chromatin of rats after intraperitoneal injection of cobalt(II)acetate, Chem. Res. Toxicol. 7 (1994) 329-335.
65. [65] A. Denda, Q. Tang, T. Endoh, T. Tsujiuchi, K. Horiguchi, O. Noguchi, Y. Mizumoto, D. Nakae, Y. Konishi, Prevention by acetylsalicylic acid of liver cirrhosis and carcinogenesis as well as generations of 8-hydroxydeoxyguanosine and thiobarbituric acid-reactive substances caused by a choline-deficient, L-amino acid-defined diet in rats, Carcinogenesis 15 (1994) 1279-1283.
66. [66] D. Nakae, N. Andoh, Y. Mizumoto, T. Endoh, N. Shimoji, K. Horiguchi, K. Shiraiwa, K. Tamura, A. Denda, Y. Konishi, Selective 8-hydroxyguanine formation in pancreatic DNA due to a single intravenous administration of 4-hydroxyaminoquinoline 1-oxide in rats, Cancer Lett. 83 (1-2) (1994) 97-103.
67. [67] F. Hayashi, H. Tamura, J. Yamada, H. Kasai, T. Suga, Characteristics of the hepatocarcinogenesis caused by dehydroepiandrosterone, a peroxisome proliferator, in male F-344 rats, Carcinogenesis 15 (1994) 2215-2219.
68. [68] C.Y. Huang, M.W. Wilson, L.T. Lay, C.K. Chow, L.W. Robertson, H.P. Glauert, Increased 8-hydroxydeoxyguanosine in hepatic DNA of rats treated with the peroxisome proliferators ciprofibrate and perfluorodecanoic acid, Cancer Lett. 87 (1994) 223-228.
69. [69] J. Suzuki, Y. Inoue, S. Suzuki, Changes in the urinary excretion level of 8-hydroxyguanine by exposure to reactive oxygen-generating substances, Free Rad. Biol. Med. 18 (1995) 431-436.
70. [70] H.M. Shen, C.N. Ong, B.L. Lee, C.Y. Shi, Aflatoxin B-1-induced 8-hydroxydeoxyguanosine formation in rat hepatic DNA, Carcinogenesis 16 (1995) 419-422.
71. [71] S.H. Cho, J.G. Im, Y.S. Choi, Y.S. Son, M.H. Chung, Lipid peroxidation and 8-hydroxydeoxyguanosine formation in rats fed fish oil with different levels of vitamin E, J. Nut. Sci. Vitaminol. 41 (1995) 61-72.
72. [72] A. Takagi, K. Sai, T. Umemura, R. Hasegawa, Y. Kurokawa, Inhibitory effects of vitamin E and ellagic acid on 8-hydroxydeoxyguanosine formation in liver nuclear DNA of rats treated with 2-nitropropane, Cancer Lett. 91 (1995) 139-144.
73. [73] P.J. Sausen, D.C. Lee, M.L. Rose, R.C. Cattley, Elevated 8-hydroxydeoxyguanosine in hepatic DNA of rats following exposure to peroxisome proliferators: relationship to mitochondrial alterations, Carcinogenesis 16 (1995) 1795-1801.
74. [74] M. Inagake, T. Yamane, Y. Kitao, K. Oya, H. Matsumoto, N. Kikuoka, H. Nakatani, T. Takahashi, H. Nishimura, A. Iwashima, Inhibition of 1,2-dimethylhydrazine-induced oxidative DNA damage by green tea extract in rat, Jpn. J. Cancer Res. 86 (1995) 1106-1111.
75. [75] T. Tsujiuchi, E. Kobayashi, D. Nakae, Y. Mizumoto, N. Andoh, H. Kitada, K. Ohashi, T. Fukuda, A. Kido, M. Tsutsumi, A. Denda, Y. Konishi, Prevention by methionine of enhancement of hepatocarcinogenesis by coadministration of a choline-deficient L-amino acid-defined diet and ethionine in rats, Jpn. J. Cancer Res. 86 (1995) 1136-1142.
76. [76] T. Akiyama, S. Hamazaki, S. Okada, Absence of ras mutations and low incidence of p53 mutations in renal cell carcinomas induced by ferric nitrilotriacetate, Jpn. J. Cancer Res. 86 (1995) 1143-1149.
77. [77] R. Hasegawa, T. Chujo, K. Saikato, T. Umemura, A. Tanimura, Y. Kurokawa, Preventive effects of green tea against liver oxidative DNA damage and hepatotoxicity in rats treated with 2-nitropropane, Food Chem. Toxicol. 33 (1995) 961-970.
78. [78] Y. Yamano, J. Kagawa, T. Hanaoka, T. Takahashi, H. Kasai, S. Tsugane, S. Watanabe, Oxidative DNA damage induced by silica in vivo, Environ. Res. 69 (1995) 102-107.
79. [79] T. Umemura, R. Hasegawa, K. Sai-Kato, A. Nishikawa, S. Toyokuni, K. Uchida, T. Inoue, Y. Kurokawa, Prevention by 2-mercaptoethane sulfonate and N-acetylcysteine of renal oxidative damage in rats treated with ferric nitrilotriacetate, Jpn. J. Cancer Res. 87 (1996) 882-886.
80. [80] A.M. Tritscher, A.M. Seacat, J.D. Yager, J.D. Groopman, B.D. Miller, D. Bell, T.R. Sutter, G.W. Lucier, Increased oxidative DNA damage in livers of 2,3,7,8-tetrachlorodibenzo-p-dioxin treated intact but not ovariectomized rats, Cancer Lett. 98 (1996) 219-225.
81. [81] T. Kato, R. Hasegawa, D. Nakae, M. Hirose, M. Yaono, L. Cui, Y. Kobayashi, Y. Konishi, N. Ito, T. Shirai, Dose-dependent induction of 8-hydroxyguanine and preneoplastic foci in rat liver by a food-derived carcinogen, 2-amino-3[8-dimethylimidazo-4,5-f]quinoxaline, at low dose levels, Jpn. J. Cancer Res. 87 (1996) 127-133.
82. [82] C. Ip, S.P. Briggs, A.D. Haegele, H.J. Thompson, J. Storkson, J.A. Scimeca, The efficacy of conjugated linoleic acid in mammary cancer prevention is independent of the level or type of fat in the diet, Carcinogenesis 17 (1996) 1045-1050.
83. [83] A. Yarborough, T.-J. Zhang, T.-M. Hsu, R.M. Santella, Immunoperoxidase detection of 8-hydroxydeoxyguanosine in aflatoxine B1-treated rat liver and human oral mucosal cells, Cancer Res. 56 (1996) 683-688.
84. [84] E. Kobayashi, T. Tsujiuchi, D. Nakae, Y. Mizumioto, N. Andoh, T. Endo, H. Kitada, M. Tsutsumi, A. Denda, Y. Konishi, Inhibitory effects of N,N′-diphenyl-p-phenylenediamine on the early stage of the enhanced hepatocarcinogenesis caused by coadministration of ethionine and a choline-deficient L-amino acid-defined diet in rats, Exp. Toxicol. Pathol. 48 (1996) 275-282.
85. [85] R. Yamaguchi, T. Hirano, S. Asami, M.-H. Chung, A. Sugita, H. Kasai, Increased 8-hydroxyguanine levels in DNA and its repair activity in rat kidney after administration of a renal carcinogen, ferric nitrilotriacetate, Carcinogenesis 17 (1996) 2419-2422.
86. [86] K.B. Kim, B.M. Lee, Oxidative stress to DNA, protein, and antioxidant enzymes (superoxide dismutase and catalase) in rats treated with benzo[a]pyrene, Cancer Lett. 113 (1997) 205-212.
87. [87] M. Lodovici, C. Casalini, C. Briani, P. Dolara, Oxidative liver DNA damage in rats treated with pesticide mixtures, Toxicology 117 (1997) 55-60.
88. [88] D. Nakae, Y. Kobayashi, H. Akai, N. Ando, H. Satoh, K. Ohashi, M. Tsutsumi, Y. Konishi, Involvement of 8-hydroxyguanine formation in the initiation of rat liver carcinogenesis by low dose levels of N-nitrosodiethylamine, Cancer Res. 57 (1997) 1281-1287.
89. [89] H. Kasai, P.F. Grain, Y. Kuchino, S. Nishimura, A. Ootsuyama, H. Tanooka, Formation of 8-hydroxyguanine moiety in cellular NDA by agents producing oxygen radicals and evidence for its repair, Carcinogenesis 7 (1986) 1849-1851.
90. [90] K. Frenkel, H. Wei, Formation of oxidazed nucleosides in DNA of mouse skin treated with tumor promoters, Free Rad. Biol. Med. 1 (1990) 170.
91. [91] T. Masuda, N. Miyasaka, T. Kato, Y. Ueno, Formation of the 8-hydroxydeoxyguanosine moiety in hepatic DNA of mice orally administered with luteoskyrin, a bisanthraquinoid mycotoxin, Toxicol. Lett. 58 (1991) 287-295.
92. [92] S.P. Faux, J.F. Francis, A.G. Smith, J.K. Chipman, Induction of 8-hydroxydeoxyguanosine in ah-responsive mouse liver by iron and aroclor 1254, Carcinogenesis 13 (1992) 247-250.
93. [93] H. Wei, K. Frenkel, Suppression of tumor promoter-induced oxidative events and DNA damage in vivo by sarcophytol A: a possible mechanism of antipromotion, Cancer Res. 52 (1992) 2298-2303.
94. [94] F.L. Chung, Y. Xu, Increased 8-oxodeoxyguanosine levels in lung DNA of A/J mice and F344 rats treated with the tobacco-specific nitrosamine 4-(methylnitrosamine)-1-(3-pyridyl)-1-butanone, Carcinogenesis 13 (1992) 1269-1272.
95. [95] Y. Xu, C.T. Ho, S.G. Amin, C. Han, F.L. Chung, Inhibition of tobacco-specific nitrosamine-induced lung toumorigenesis in A/J mice by green tea and its major polyphenol as antioxidants, Cancer Res. 52 (1992) 3875-3879.
96. [96] M. Hayakawa, T. Ogawa, S. Sugiyama, M. Tanaka, T. Ozawa, Conversion of deoxyguanosine into 8-hydroxydeoxyguanosine in mouse liver mitochondrial DNA by administration of azidothymidine, Int. J. Immunother. 8 (1992) 171-175.
97. [97] P. Kolachana, V.V. Subrahmanyam, K.B. Meyer, L.P. Zhang, M.T. Smith, Benzene and its phenolic metabolites produce oxidative DNA damage in HL60 cells in vitro and in the bone marrow in vivo, Cancer Res. 53 (1993) 1023-1026.
98. [98] K. Frenkel, H. Wei, R. Bhimani, J. Ye, J.A. Zadunaisky, M.-T. Huang, T. Ferraro, A.M. Conney, D. Grunberger, Inhibition of tumor promoter-mediated processes in mouse skin and bovine lens by caffeic acid phenethyl ester, Cancer Res. 53 (1993) 1255-1261.
99. [99] L. Wei, H. Wei, K. Frenkel, Sensitivity to tumor promotion of SENCAR and C57BL/6J mice correlates with oxidative events and DNA damage, Carcinogenesis 14 (1993) 841-847.
100. [100] H.C. Wei, K. Frenkel, Relationship of oxidative events and DNA oxidation in SENCAE mice to invivo promoting activity of phorbol ester-type tumor promotors, Carcinogenesis 14 (1993) 1195-1201.
101. [101] Y. Hattori-Nakakuki, C. Nishigori, K. Okamoto, S. Imamura, H. Hiai, S. Toyokuni, Formation of 8-hydroxy-2′-deoxyguanosine in epidermis of hairless mice exposed to near-UV, Biochim. Biophys. Res. Comm. 201 (1994) 1132-1139.
102. [102] M. Dahlhaus, E. Almstadt, K.E. Appel, The pentachlorophenol metabolite tetrachloro-p-hydroquinone induces the formation of 8-hydroxy-2-deoxyguanosine in liver DNA of male B6C3F1 mice, Toxicol. Lett. 74 (1994) 265-274.
103. [103] T.M. Hagen, S. Huang, J. Curnutte, P. Fowler, V. Martinez, C.M. Wehr, B.N. Ames, F.V. Chisari, Extensive oxidative DNA damage in hepatocytes of transgenic mice with chronic active hepatitis destined to develop hepatocellular carcinoma, Proc. Natl. Acad. Sci. USA 91 (1994) 12808-12812.
104. [104] W.H. Fischer, W.K. Lutz, Correlation of individual papilloma latency time with DNA adducts, 8-hydroxy-2′-deoxyguanosine, and the rate of DNA synthesis in the epidermis of mice treated with 7,12-dimethylbenz[a]anthracene, Proc. Natl. Acad. Sci. USA 92 (1995) 5900-5904.
105. [105] K. Sai-Kato, T. Umemura, A. Takagi, R. Hasegawa, A. Tanimura, Y. Kurokawa, Pentachlorophenol-induced oxidative DNA damage in mouse liver and protective effect of antioxidants, Food Chem. Toxicol. 33 (1995) 877-882.
106. [106] L. Liu, P.G. Wells, DNA oxidation as a potential molecular mechanism mediating drug-induced birth defects: phenytoin and structually rrelated teratogens initiate the formation of 8-hydroxy-2′-deoxyguanosine in vitro and invivo in murine maternal hepatic and embrionic tissues, Free Radic. Biol. Med. 19 (1995) 639-648.
107. [107] T. Umemura, K. Saikato, A. Takagi, R. Hasegawa, Y. Kurokawa, Oxidative DNA damage and cell proliferation in the livers of B6C3F1 mice exposed to pentachlorophenol in their diet, Fundamental Appl. Toxicol. 30 (1996) 285-289.
108. [108] E.W. Austin, J.M. Parrish, D.H. Kinder, R.J. Bull, Lipid peroxidation and formation of 8-hydroxydeoxyguanosine from acute doses of halogenated acetic acids, Fundamental Appl. Toxicol. 31 (1996) 77-82.
109. [109] U. Hattori, C. Nishigori, T. Tanaka, K. Uchida, O. Nikaido, T. Osawa, H. Hiai, S. Imamura, S. Toyokuni, 8-Hydroxy-2′-deoxyguanosine is increased in epidermal cells of hairless mice after chronic ultraviolet exposure, J. Invest. Dermatol. 107 (1996) 733-737.
110. [110] T. Ichinose, Y. Yajima, M. Nagashima, S. Takenoshita, Y. Nagamachi, M. Sagai, Lung carcinogenesis and formation of 8-hydroxydeoxyguanosine in mice by diesel exhaust particles, Carcinogenesis 18 (1997) 185-192.
111. [111] D. Zhang, S. Okada, Y. Yu, P. Zheng, R. Yamaguchi, H. Kasai, Vitamin E inhibits apotosis, DNA modification and cancer incidence induced by iron-mediated peroxidation in Wister rat kidney, Cancer Res. 57 (1997) 2410-2414.
112. [112] D.C. Malins, R. Haimanot, 4,6-Diamino-5-formanidopyrimidine, 8-hydroxyguanine and 8-hydroxyadenine in DNA from neoplastic liver of English sole exposed to carcinogens, Biochim. Biophys. Res. Commun. 173 (1990) 614-619.
113. [113] M. Nishimoto, W.T. Roubal, J.E. Stein, U. Varanasi, Oxidative DNA damage in tissues of english sole (Parophrys-Vetulus) exposed to nitrofurantoin, Chemico-Biol. Interactions 80 (1990) 317-326.
114. [114] J.D. Kelly, G.A. Orner, J.D. Hendricks, D.E. Williams, Dietary hydrogen peroxide enhances hepatocarcinogenesis in trout: correlation with 8-hydroxy-2′-deoxyguanosine levels in liver DNA, Carcinogenesis 13 (1992) 1639-1642.
115. [115] D.C. Malins, S.J. Gunselman, Fourier-transform infrared spectroscopy and gas chromatography mass spectrometry reveal a remarkable degree of structural damage in the DNA of wild fish exposed to toxic chemicals, Proc. Natl. Acad. Sci. USA 91 (1994) 13038-13041.
116. [116] D. Roy, R.A. Floyd, J.G. Liehr, Elevated 8-hydroxydeoxyguanosine levels in DNA of diethylstilbestrol-treated Syrian hamsters: covalent DNA damage by free radicals generated by redox cycling of diethylstilbestrol, Cancer Res. 51 (1991) 3882-3885.
117. [117] L. Han, J.G. Liehr, 8-Hydroxylation of guanine bases in kidney and liver DNA of hamsters treated with estradiol: role of free radicals in estrogen-induced carcinogenesis, Cancer Res. 54 (1994) 5515-5517.
118. [118] E.S. Fiala, G. Nie, R. Sodum, C.C. Conaway, O.S. Sohn, 2-Nitropropane-induced liver DNA and RNA base modifications: differences between Sprague-Dawley rats and New Zealand White rabbits, Cancer Lett. 74 (1993) 9-14.
119. [119] K.L. Olin, M.K. Shigenaga, B.N. Ames, M.S. Golub, M.E. Gershwin, A.G. Hendrickx, C.L. Keen, Maternal dietary zinc influences DNA strand break and 8-hydroxy-2′-deoxyguanosine levels in infant rhesus monkey liver, Proc. Soc. Exp. Biol. Med. 203 (1993) 461-466.
120. [120] R. Yamaguchi, T. Hirano, Y. Ootsuyama, S. Asami, Y. Tsurudome, S. Fukada, H. Yamato, T. Tsuda, I. Tanaka, H. Kasai, Increased 8-hydroxyguanine in DNA and its repair activity in hamster and rat lungs after intratracheal instillation of crocidolite asbestos and glass fiber: a new approach to the assessment of man-made-mineral fiber carcinogenicity, Proc. 88th Ann. Meeting Am. Assoc. Cancer Res. 518 (1997) San Diego.
121. [121] T. Hirano, Y. Homma, H. Kasai, Formation of 8-hydroxyguanine in DNA by aging and oxidative stress, in: R.G. Cutler, L. Packer, J. Bertram, A. Mori (Eds.), Oxidative Stress and Aging, pp. 69-76.
122. [122] D. Nakae, Y. Mizumoto, E. Kobayashi, O. Noguchi, Y. Konishi, Improved genomic/nuclear DNA extraction for 8-hydroxydeoxyguanosine analysis of small amounts of rat liver tissue, Cancer Lett. 97 (1995) 233-239.
123. [123] M. Nakajima, T. Takeuchi, K. Morimoto, Determination of 8-hydroxydeoxyguanosine in human cells under oxygen-free conditions, Carcinogenesis 17 (1996) 787-791.
124. [124] K.C. Cundy, R. Kohen, B.N. Ames, Determination of 8-hydroxydeoxyguanosine in human urine: a possible assay for in vivo oxidative DNA damage' oxigen radicals in biology and medicine, in: M.G. Simic, K.A. Taylor, J.F. Ward, C. von Sonntag (Eds.), Basic Life Sciences, vol. 49, Plenum Press, NY, 1991, pp. 479-482.
125. [125] M.K. Shigenaga, C.J. Gimeno, B.N. Ames, Urinary 8-hydroxy-2′-deoxyguanosine as a biological marker of in vivo oxidative DNA damage, Proc. Natl. Acad. Sci. USA 86 (1989) 9697-9701.
126. [126] H. Kiyosawa, M. Suko, T. Takaishi, H. Morita, H. Okudaira, K. Ito, H. Kasai, S. Nishimura, The effect of smoking on 8-hydroxydeoxyguanosine levels in human lung DNA, Free Rad. Biol. Med. 1 (1990) 50.
127. [127] H. Kiyosawa, M. Suko, H. Okudaira, K. Murata, T. Miyamoto, M.H. Chung, H. Kasai, S. Nishimura, Cigarette smoking induces formation 8-hydroxydeoxyguanosine, one of the oxidative DNA damages in human peripheral leukocytes, Free Rad. Res. Commun. 11 (1990) 23-27.
128. [128] G.G. Fraga, P.A. Motchnik, M.K. Shigenaga, H.J. Helbock, R.A. Jacob, B.N. Ames, Ascorbic acid protects against endogenous oxidative DNA damage in human sperm, Proc. Natl. Acad. Sci. USA 88 (1991) 11003-11006.
129. [129] M. Hayakawa, K. Torii, S. Sugiyama, M. Tanaka, T. Ozawa, Age-associated accumulation of 8-hydroxydeoxyguanosine in mitochondrial DNA of human diaphragm, Biochim. Biophys. Res. Commun. 179 (1991) 1023-1029.
130. [130] S. Loft, K. Vistisen, M. Ewertz, A.T. Jonneland, K. Overvad, H.E. Poulsen, Oxidative DNA damage estimated by 8-hydroxy-deoxyguanosine excretion in humans: influence of smoking, gender and body mass index, Carcinogenesis 13 (1992) 2241-2247.
131. [131] E.-M. Park, M.K. Shigenaga, P. Degan, T.S. Korn, B.N. Ames, Assay of excised oxidative DNA lesions: isolation of 8-oxoguanine and its nucleoside derivatives from biological fruids with a monoclonal antibody column, Proc. Natl. Acad. Sci. USA 89 (1992) 3375-3379.
132. [132] V.L. Wilson, B.C. Taffe, P.G. Shields, A.C. Povey, C.C. Harris, Detection and quantification of 8-hydroxydeoxyguanosine adducts in peripheral blood of people exposed to ionizing radiation, Environ. Health Perspect. 99 (1993) 261-263.
133. [133] D.C. Malins, E.H. Holmes, N.L. Polissar, S.J. Gunselman, The etiology of breast cancer: characteristic alterations in hydroxyl radical-induced DNA base lesions during oncogenesis with potential for evaluating incidence risk, Cancer 71 (1993) 3036-3043.
134. [134] T. Hanaoka, S. Tsugane, Y. Yamano, T. Takahashi, H. Kasai, Y. Natori, S. Watanabe, Quantitative analysis of 8-hydroxyguanine in peripheral blood cells: an application for asbestosis patients, Int. Arch. Occup. Environ. Health 65 (1993) S215-S217.
135. [135] S. Bashir, G. Harris, M.A. Denman, D.R. Blake, P.G. Winyard, Oxidative DNA damage and cellular sensitivity to oxidative stress in human autoimmune diseases, Ann. Rheumatic Diseases 52 (1993) 659-666.
136. [136] P. Mecocci, U. Macgarvey, A.E. Kaufman, D. Koontz, J.M. Shoffner, D.C. Wallace, M.F. Beal, Oxidative damage to mitochondrial DNA shows marked age-dependent increases in human brain, Ann. Neurol. 34 (1993) 609-616.
137. [137] T. Inoue, Z. Mu, K. Sumikawa, K. Adachi, T. Okochi, Effect of physical exercise on the content of 8-hydroxydeoxyguanosine in nuclear DNA prepared from human lymphocytes, Jpn. J. Cancer Res. 84 (1993) 720-725.
138. [138] C.A. Viguie, B. Frei, M.K. Shigenaga, B.N. Ames, L. Packer, G.A. Brooks, Antioxidant status and indexes of oxidative stress during consecutive days of exercise, J. Appl. Physiol. 75 (1993) 566-572.
139. [139] R. Shimoda, M. Nagashima, M. Sakamoto, N. Yamaguchi, S. Hirohashi, J. Yokota, H. Kasai, Increased formation of oxidative DNA damage, 8-hydroxydeoxyguanosine, in human livers with chronic hepatitis, Cancer Res. 54 (1994) 3171-3172.
140. [140] J. Lunec, K. Herbert, S. Blount, H.R. Griffiths, P. Emery, 8-Hydroxydeoxyguanosine: a marker of oxidative DNA damage in systemic lupus erythematosus, FEBS Lett. 348 (1994) 131-138.
141. [141] T. Takeuchi, M. Nakajima, Y. Ohta, K. Mure, T. Takeshita, K. Morimoto, Evaluation of 8-hydroxydeoxyguanosine, a typical oxidative DNA damage, in human leukocytes, Carcinogenesis 15 (1994) 1519-1523.
142. [142] K. Okamoto, S. Toyokuni, K. Uchida, O. Ogawa, J. Takenewa, Y. Kakehi, H. Kinoshita, Y. Hattori-Nakakuki, H. Hiai, O. Yoshida, Formation of 8-hydroxy-2′-deoxyguanosine and 4-hydroxy-2-nonenal-modified proteins in human renal-cell carcinoma, Int. J. Cancer 58 (1994) 825-829.
143. [143] J.R. Sanchezramos, E. Overvik, B.N. Ames, A marker of oxyradical-mediated DNA damage (8-hydroxy-2′deoxyguanosine) is increased in nigro-striatum of Parkinson's disease brain, Neurodegeneration 3 (1994) 197-204.
144. [144] M. Gao, L.S. Levy, S.P. Faux, T.C. Aw, R.A. Braithwaite, S.S. Brown, Use of molecular epidemiological techniquiques in a pilot study on workers exposed to chromium, Occup. Environ. Med. 51 (1994) 663-668.
145. [145] S. Lagorio, C. Tagesson, F. Forastiere, I. Iavarone, O. Axelson, A. Carere, Exposure to benzene and urinary concentrations of 8-hydroxydeoxyguanosine, a biological marker of oxidative damage to DNA, Occup. Environ. Med. 51 (1994) 739-743.
146. [146] P.L. Carmichael, A. Hewer, M.R. Osborne, A.J. Strain, D.H. Phillips, Detection of bulky DNA lesions in the liver of patients with Wilson's disease and primary haemochromatosis, Mutation Res. 326 (1995) 235-243.
147. [147] R.K. Brown, A. Mcburney, J. Lunec, F.J. Kelly, Oxidative damage to DNA in patients with cystic fibrosis, Free Rad. Biol. Med. 18 (1995) 801-806.
148. [148] H. Verhagen, H.E. Poulsen, S. Loft, G. van Poppel, M.I. Willems, P.J. van Bladeren, Reduction of oxidative DNA-damage in humans by brussels, Carcinogenesis 16 (1995) 969-970.
149. [149] M. Nagashima, H. Tsuda, S. Takenoshita, Y. Nagamachi, S. Hirohashi, J. Yokota, H. Kasai, 8-hydroxydeoxyguanosine levels in DNA of human breast cancers are not significantly different from those of non-cancerous breast tissues by the HPLC-ECD method, Cancer Lett. 90 (1995) 157-162.
150. [150] C. Tagesson, M. Kallberg, C. Klintenberg, H. Starkhammar, Determination of urinary 8-hydroxydeoxyguanosine by automated coupled-column high performance liquid chromatography: a powerful technique for assaying in vivo oxidative DNA damage in cancer patients, Eur. J. Cancer 31 (A) (1995) 934-940.
151. [151] R.P.F. Schins, P.A.E.L. Schilderman, P.J.A. Borm, Oxidative DNA damage in peripheral blood lymphocytes of coal workers, Int. Arch. Occup. Environ. Health 67 (1995) 153-157.
152. [152] S.I.S. Rattan, G.E. Siboska, F.P. Wikmar, B.F.C. Clark, P. Woolley, Levels of oxidative DNA damage product 8-hydroxy-2′-deoxyguanosine in human serum increase with age, Med. Sci. Res. 23 (1995) 469-470.
153. [153] P. Degan, S. Bonassi, M. De Caterina, L.G. Korkina, L. Pinto, F. Scopacasa, A. Zatterale, R. Calzone, G. Pagano, In vivo accumuration of 8-hydroxy-2′-deoxyguanosine in DNA correlates with release of reactive oxygen species in Fanconi's anaemia families, Carcinogenesis 16 (1995) 735-741.
154. [154] K. Bialkowski, R. Kowara, W. Windorbska, R. Olinski, 8-Oxo-2′-deoxyguanosine level in lymphocytes DNA of cancer patients undergoing radiotherapy, Cancer Lett. 99 (1996) 93-97.
155. [155] P. Dandona, K. Thusu, S. Cook, B. Snyder, J. Makowski, D. Armstrong, T. Nicotera, Oxidative damage to DNA in diabetes mellitus, Lancet 347 (1996) 444-445.
156. [156] S.C. Baik, H.S. Youn, M.H. Chung, W.K. Lee, M.J. Cho, G.H. Ko, C.K. Park, H. Kasai, K.H. Rhee, Increased oxidative DNA damage in Helicobacter pylori-infected human gastric mucosa, Cancer Res. 56 (1996) 1279-1282.
157. [157] S. Asami, T. Hirano, R. Yamaguchi, Y. Tomioka, H. Itoh, H. Kasai, Increase of a type of oxidative DNA damage, 8-hydroxyguanine, and its repair activity in human leukocytes by cigarette smoking, Cancer Res. 56 (1996) 2546-2549.
158. [158] C. Dennog, A. Hartmann, G. Frey, G. Speit, Detection of DNA damage after hyperbaric oxygen (HBO) therapy, Mutagenesis 11 (1996) 605-609.
159. [159] C. Tagesson, M. Kallberg, G. Wingren, Urinary malondialdehyde and 8-hydroxydeoxyguanosine as potential markers of oxidative stress in industrial art glass workers, Int. Arch. Occup. Environ. Health 69 (1996) 5-13.
160. [160] J. Musarrat, J. Arezina-Wilson, A.A. Wani, Prognostic and aetiological relevance of 8-hydroxyguanosine in human breast carcinogenesis, Eur. J. Cancer 32 (A) (1996) 1209-1214.
161. [161] R.I. Nilsson, R.G. Nordlinder, C. Tagesson, S. Walles, B.G. Jarvholm, Genotoxic effects in workers exposed to low levels of benzene from gasoline, Am. J. Ind. Med. 30 (1996) 317-324.
162. [162] M. Nakajima, T. Takeuchi, T. Takeshita, K. Morimoto, 8-hydroxydeoxyguanosine in human leukocyte DNA and daily health practice factors: effects of individual alcohol sensitivity, Environ. Health Perspect. 104 (1996) 1336-1338.
163. [163] C.G. Fraga, P.A. Motchnik, A.J. Wyrobek, D.M. Rempel, B.N. Ames, Smoking and low antioxidant levels increase oxidative damage to sperm DNA, Mutation Res. 351 (1996) 199-203.
164. [164] T. Yamamoto, K. Hosokawa, T. Tamura, H. Kanno, M. Urabe, H. Honjo, Urinary 8-hydroxy-2′-deoxyguanosine (8-OHdG) levels in women with or without gynecologic cancer, J. Obstet. Gynaecol. Res. 22 (1996) 59-363.
165. [165] H. Daube, G. Scherer, K. Riedel, T. Ruppert, A.R. Tricker, P. Rosenbaum, F. Adlkofer, DNA adducts in human placenta in relation to tobacco smoke exposure and plasma antioxidant status, J. Cancer Res. Clin. Oncol. 123 (1997) 141-151.
166. [166] K. Takahashi, G. Pan, H. Kasai, T. Hanaoka, Y. Feng, N. Liu, S. Zhang, Z. Xu, T. Tsuda, H. Yamato, T. Higashi, T. Okubo, Relationship between asbestos exposures and 8-hydroxydeoxyguanosine levels in leukocytic DNA of workers at a Chinese asbestos-material plant, Int. J. Occup. Environ. Health 3 (1997) 111-119.
167. [167] S. Asami, H. Manabe, J. Miyake, Y. Tsurudome, T. Hirano, R. Yamaguchi, H. Itoh, H. Kasai, Cigarette smoking induces an increase in oxidative DNA damage, 8-hydroxydeoxyguanosine, in a central site of the human lung, Carcinogenesis 18 (1997) in press.
168. [168] M. Hollstein, D. Sidransky, B. Vogelstein, C.C. Harris, p53 mutations in human cancers, Science 253 (1991) 49-53.
169. [169] J. Hegler, D. Bittner, S. Boiteux, B. Epe, Quantification of oxidative DNA modifications in mitochondria, Carcinogenesis 14 (1993) 2309-2312.
170. [170] C. Richter, J. Park, B. Ames, Normal oxidative damage to mitochondrial and nuclear-DNA is extensive, Proc. Natl. Acad. Sci. USA 85 (1988) 6465-6467.
171. [171] J.L. Ravant, R.J. Turesky, E. Gremaud, L.J. Trudel, R.H. Stader, Determination of 8-oxoguanine in DNA by gas chromatography-mass spectrometry and HPLC-electrochemical detection: overestimation of the background level of the oxidized base by the gas chromatography-mass spectrometry assay, Chem. Res. Toxicol. 8 (1995) 1039-1045.
172. [172] H.G. Claycamp, Phenol sensitization of DNA to subsequent oxidative damage in 8-hydroxyguanine assays, Carcinogenesis 13 (1992) 1289-1292.
173. [173] S. Toyokuni, T. Tanaka, Y. Hattori, Y. Nishiyama, A. Yoshida, K. Uchida, H. Ochi, T. Osawa, Quantitative immunohistochemical determination of 8-hydroxy-2′-deoxyguanosine by monoclonal antibody N45.1: its application to ferric nitrilotriacetate-induced renal carcinogenesis model, Laboratory Invest. 76 (1997) 365-374.
174. 8Gua glycosylase in rat kidneys by potassium bromate (KBrO3), a renal oxidative carcinogen, Mutation Res. 364 (1996) 227-233.
175. [175] R. Bases, F. Mendez, W.A. Franklin, Enhanced repair endonuclease activities from radiation-arrested G2 phase mammalian cells, Int. J. Radiat. Biol. 65 (1994) 591-603.
176. [176] H.-S. Kim, Y.-W. Park, H. Kasai, S. Nishimura, C.-W. Park, K.-H. Choi, M.-H. Chung, Induction of E. coli oh8Gua endonuclease by oxidative stress: its significance in aerobic life, 1996.
177. [177] J. Hall, H. Bresil, F. Donato, C.P. Wild, N.A. Loktio-nova, O.I. Kazanoya, I.P. Komyakov, V.G. Lemek-hov, A.J. Likhachev, R. Montesano, Alkylation and oxidative-DNA damage repair activity in blood leukocytes of smokers and non-smokers, Int. J. Cancer. 54 (1990) 728-733.
178. [178] H. Kasai, S. Nishimura, Formation of 8-hydroxyguanine by oxidative DNA damage, its repair and its mutagenic effects, Adv. Mutagen. Res. 4 (1993) 31-45.
179. [179] Y. Luo, E.S. Henle, S. Linn, Oxidative damage to DNA constituents by iron-mediated Fenton reactions: the deoxycytidine family, J. Biol. Chem. 271 (1996) 21167-21176.
180. [180] E.S. Henle, Y. Luo, W. Gassmann, S. Linn, Oxidative damage to DNA constituents by iron-mediated Fenton reactions: the deoxyguanosine family, J. Biol. Chem. 271 (1996) 21177-21186.
181. [181] D.I. Feig, L.C. Sowers, L.A. Loeb, Reverse chemical mutagenesis: identification of the mutagenic lesions resulting from reactive oxygen species-mediated damage to DNA, Proc. Natl. Acad. Sci. USA 91 (1994) 6609-6613.
182. [182] J.R. Wagner, C.C. Hu, B.N. Ames, Endogenous oxidative damage of deoxycytidine in DNA, Proc. Natl. Acad. Sci. USA 89 (1992) 3380-3384.
183. [183] N. Murata-Kamiya, H. Kamiya, M. Muraoka, H. Kaji, H. Kasai, Comparison of oxidation products from DNA components by γ-irraiation and Fenton-type reactions, J. Radiat. Res. 38 (1997) 121-131.
184. [184] H. Kamiya, H. Kasai, Formation of 2-hydroxydeoxyadenosine triphosphate, an oxidatively damaged nucleotide, and its incorporation by DNA polymerases: steady-state kinetics of the incorporation, J. Biol. Chem. 270 (1995) 19446-19450.
185. [185] H. Kamiya, H. Kasai, Effects of sequence contexts on misincorporation of nucleotides opposite 2-hydroxyadenine, FEBS Lett. 391 (1996) 113-116.
186. [186] H. Kamiya, H. Kasai, Substitution and deletion mutations induced by 2-hydroxyadenine in Escherichia coli: effects of sequence contexts in leading and lagging strands, Nucl. Acids Res. 25 (1997) 304-310.
187. [187] H. Kamiya, H. Kasai, Mutations induced by 2-hydroadenine during leading and lagging strand syntheses in mammalian cells, Biochemistry (1997) submitted.
188. [188] Y. Tsurudome, T. Hirano, R. Yamaguchi, S. Asami, H. Kamiya, H. Itoh, H. Kasai, Comparison of repair enzyme activity for 8-hydroxyguanine and 2-hydroxyadenine, Proc. 88th Ann. Meeting Am. Assoc. Cancer Res. 524 (1997) San Diego.
189. [189] N. Murata-Kamiya, H. Kamiya, N. Iwamoto, H. Kasai, Formation of a mutagen, glyoxal, from DNA treated with oxygen free radicals, Carcinogenesis 16 (1995) 2251-2253.
190. [190] N. Murata-Kamiya, H. Kaji, H. Kasai, Types of mutations induced by glyoxal, a major oxidative DNA damage product, in Salmonella typhimurium, Mutation Res. 377 (1997) 13-16.
191. [191] N. Murata-Kamiya, H. Kamiya, H. Kaji, H. Kasai, Mutational specificity of glyoxal, a product of DNA oxidation, in the lacI gene of wild-type Escherichia coli W3110, Mutation Res. 377 (1997) 255-262.
192. [192] N. Murata-Kamiya, H. Kamiya, H. Kaji, H. Kasai, Glyoxal, a major product of DNA oxidation, induces mutations at G:C sites on a shuttle vector plasmid replicated in mammalian cells, Nucl. Acids Res. 25 (1997) 1897-1902.
193. [193] T.J. McBride, B.D. Preston, L.A. Loeb, Mutagenic spectrum resulting from DNA damage by oxygen radicals, Biochemistry 30 (1991) 207-213.
194. [194] H. Kasai, A. Iida, Z. Yamaizumi, S. Nishimura, H. Tanooka, 5-Formyldeoxyuridine: a new type of DNA damage induced by ionizing radiation and its mutagenicity to Salmonella strain TA 102, Mutation Res. 243 (1990) 249-253.
195. [195] M. Yoshida, K. Makino, H. Morita, H. Terao, Y. Ohyama, H. Ide, Substrate and mispairing properties of 5-formyl-2′-deoxyuridine 5′-triphosphate assessed by in vitro DNA polymerase reactions, Nucl. Acid. Res. 25 (1997) 1570-1577.