X-inactivation in female human embryonic stem cells is in a nonrandom pattern and prone to epigenetic alterations

Proceedings of the National Academy of Sciences of the United States of America

Volumn 105, Issue 12, 2008, Pages 4709-4714

  Shen, Yin ^a   Matsuno, Youko ^c   Fouse, Shaun D ^a   Rao, Nagesh ^a   Root, Sierra ^d   Xu, Renhe ^d   Pellegrini, Matteo ^b   Riggs, Arthur D ^c   Fan, Guoping ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

^c CITY OF HOPE NATIONAL MEDICAL CENTER   (United States)

^d UNIVERSITY OF CONNECTICUT HEALTH CENTER   (United States)

Author keywords

Culture variation; DNA methylation; Gene regulation

Indexed keywords

ALLELE; ARTICLE; CPG ISLAND; EMBRYONIC STEM CELL; EPIGENETICS; FEMALE; GENE ACTIVATION; GENE EXPRESSION; HUMAN; HUMAN CELL; METHYLATION; MUTATION; PRIORITY JOURNAL; X CHROMOSOME INACTIVATION; X CHROMOSOME LINKAGE; CELL CULTURE; CYTOLOGY; DNA METHYLATION; GENE EXPRESSION REGULATION; GENETIC EPIGENESIS; GENETIC MARKER; GENETICS; GENOTYPE; METABOLISM; PROMOTER REGION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SINGLE NUCLEOTIDE POLYMORPHISM; X CHROMOSOMAL INHERITANCE;

COMPLEMENTARY DNA; UNCLASSIFIED DRUG; UNTRANSLATED RNA; X (INACTIVE) SPECIFIC TRANSCRIPT (XIST); X (INACTIVE)-SPECIFIC TRANSCRIPT (XIST);

CELLS, CULTURED; CPG ISLANDS; DNA METHYLATION; DNA, COMPLEMENTARY; DOSAGE COMPENSATION, GENETIC; EMBRYONIC STEM CELLS; EPIGENESIS, GENETIC; FEMALE; GENES, X-LINKED; GENETIC MARKERS; GENOTYPE; HUMANS; POLYMORPHISM, SINGLE NUCLEOTIDE; PROMOTER REGIONS (GENETICS); REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, UNTRANSLATED; X CHROMOSOME INACTIVATION;

EID: 42449163490     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.0712018105     Document Type: Article

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