Differential N-glycosylation of a monoclonal antibody expressed in tobacco leaves with and without endoplasmic reticulum retention signal apparently induces similar in vivo stability in mice

Plant Biotechnology Journal

Volumn 9, Issue 9, 2011, Pages 1120-1130

  Triguero, Ada ^a   Cabrera, Gleysin ^a   Rodríguez, Meilyn ^a   Soto, Jeny ^a   Zamora, Yasser ^a   Pérez, Marlene ^a   Wormald, Mark R ^b   Cremata, José A ^a  

^a CENTER FOR GENETIC ENGINEERING AND BIOTECHNOLOGY   (Cuba)

^b UNIVERSITY OF OXFORD   (United Kingdom)

Author keywords

Endoplasmic reticulum retention signal; In vivo stability; Plant N glycans; Recombinant antibodies; Transgenic plants

Indexed keywords

EPITOPE; HEPATITIS B ANTIBODY; HEPATITIS B ANTIGEN; MONOCLONAL ANTIBODY; PLANTIBODY; POLYSACCHARIDE; SIGNAL PEPTIDE;

ANIMAL; ARTICLE; BAGG ALBINO MOUSE; BIOSYNTHESIS; CHEMICAL STRUCTURE; COMPARATIVE STUDY; ENDOPLASMIC RETICULUM; FEMALE; GENE EXPRESSION REGULATION; GENETICS; GLYCOSYLATION; HEPATITIS B VIRUS; IMMUNOLOGY; ISOLATION AND PURIFICATION; METABOLISM; MOLECULAR CLONING; MOUSE; PLANT LEAF; PROTEIN STABILITY; RABBIT; RHIZOBIUM RADIOBACTER; TOBACCO; TRANSGENIC PLANT;

AGROBACTERIUM TUMEFACIENS; ANIMALS; ANTIBODIES, MONOCLONAL; CLONING, MOLECULAR; ENDOPLASMIC RETICULUM; EPITOPES; FEMALE; GENE EXPRESSION REGULATION, PLANT; GLYCOSYLATION; HEPATITIS B ANTIBODIES; HEPATITIS B ANTIGENS; HEPATITIS B VIRUS; MICE; MICE, INBRED BALB C; MODELS, MOLECULAR; PLANT LEAVES; PLANTIBODIES; PLANTS, GENETICALLY MODIFIED; POLYSACCHARIDES; PROTEIN SORTING SIGNALS; PROTEIN STABILITY; RABBITS; TOBACCO;

HEPATITIS B VIRUS; MAMMALIA; MURINAE; MUS; NICOTIANA TABACUM;

EID: 80955158648     PISSN: 14677644     EISSN: 14677652     Source Type: Journal    
DOI: 10.1111/j.1467-7652.2011.00638.x     Document Type: Article

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