Antitumor agents. 196. Substituted 2-thienyl-1,8-naphthyridin-4-ones: Their synthesis, cytotoxicity, and inhibition of tubulin polymerization

Journal of Medicinal Chemistry

Volumn 42, Issue 20, 1999, Pages 4081-4087

  Zhang, Shun Xiang ^a   Bastow, Kenneth F ^a   Tachibana, Yoko ^a   Kuo, Sheng Chu ^b   Hamel, Ernest ^c   Mauger, Anthony ^d   Narayanan, Ven L ^d   Lee, Kuo Hsiung ^a  

^a UNIVERSITY OF NORTH CAROLINA   (United States)

^b CHINA MEDICAL UNIVERSITY   (Taiwan)

^c NATIONAL CANCER INSTITUTE   (United States)

^d NATIONAL CANCER INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

2 (3 METHOXYPHENYL) 6 (1 PYRROLIDINYL) 4 QUINOLONE; 2 (4 CHLOROPHENYL) 6 METHYL 1,8 NAPHTHYRIDIN 4 ONE; 2 THIENYL 1,8 NAPHTHYRIDIN 4 ONE DERIVATIVE; 5,7 METHYL 2 (3' BENZO[B]THIENYL) 1,8 NAPHTHYRIDIN 4 ONE; 6 METHYL 2 (3' BENZO[B]THIENYL) 1,8 NAPHTHYRIDIN 4 ONE; 6 METHYL 2 (3' METHYL 2' THIENYL) 1,8 NAPHTHYRIDIN 4 ONE; 7 METHYL 2 (3' BENZO[B]THIENYL) 1,8 NAPHTHYRIDIN 4 ONE; 7 METHYL 2 (3' METHYL 2' THIENYL) 1,8 NAPHTHYRIDIN 4 ONE; 7 METHYL 2 (5' METHYL 2' THIENYL) 1,8 NAPHTHYRIDIN 4 ONE; ANTIMITOTIC AGENT; ANTINEOPLASTIC AGENT; COLCHICINE; COMBRETASTATIN A4; CORNIGERINE; FLAVONOL; NAPHTHYRIDINE DERIVATIVE; PACLITAXEL; PODOPHYLLOTOXIN; QUINOLONE DERIVATIVE; STEGANACIN; TUBULIN; UNCLASSIFIED DRUG; VINBLASTINE;

ARTICLE; CONTROLLED STUDY; CYTOTOXICITY; DRUG STRUCTURE; DRUG SYNTHESIS; HUMAN; HUMAN CELL; MICROTUBULE ASSEMBLY; SOLID TUMOR; TUMOR CELL LINE;

ANTINEOPLASTIC AGENTS; BIOPOLYMERS; COLCHICINE; DRUG SCREENING ASSAYS, ANTITUMOR; HUMANS; INHIBITORY CONCENTRATION 50; MODELS, MOLECULAR; NAPHTHYRIDINES; STRUCTURE-ACTIVITY RELATIONSHIP; THIOPHENES; TUBULIN; TUMOR CELLS, CULTURED;

EID: 0033533865     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm990208z     Document Type: Article

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