Antitumor agents. 178. Synthesis and biological evaluation of substituted 2-aryl-1,8-naphthyridin-4(1H)-ones as antitumor agents that inhibit tubulin polymerization

Journal of Medicinal Chemistry

Volumn 40, Issue 19, 1997, Pages 3049-3056

  Chen, Ke ^a   Kuo, Sheng Chu ^b   Hsieh, Ming Chieh ^b   Mauger, Anthony ^c   Lin, Chii M ^c   Hamel, Ernest ^c   Lee, Kuo Hsiung ^a  

^a UNIVERSITY OF NORTH CAROLINA   (United States)

^b CHINA MEDICAL UNIVERSITY   (Taiwan)

^c NATIONAL CANCER INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

1,8 NAPHTHYRIDIN 4 ONE DERIVATIVE; ANTINEOPLASTIC AGENT; COLCHICINE; COMBROSTATIN A4; KETONE DERIVATIVE; PODOPHYLLOTOXIN; TUBULIN; UNCLASSIFIED DRUG;

ANTINEOPLASTIC ACTIVITY; ARTICLE; CANCER CELL CULTURE; CYTOTOXICITY; DRUG MECHANISM; DRUG SELECTIVITY; DRUG SYNTHESIS; HUMAN; HUMAN CELL; MICROTUBULE ASSEMBLY; STRUCTURE ACTIVITY RELATION;

ANTINEOPLASTIC AGENTS; CELL SURVIVAL; COLCHICINE; DRUG SCREENING ASSAYS, ANTITUMOR; FEMALE; HUMANS; INDICATORS AND REAGENTS; MACROMOLECULAR SUBSTANCES; MALE; MOLECULAR STRUCTURE; NAPHTHYRIDINES; STRUCTURE-ACTIVITY RELATIONSHIP; TUBULIN; TUMOR CELLS, CULTURED;

EID: 0030823308     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm970146h     Document Type: Article

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