Synthesis, structure, and antiproliferative activity of selenophenfurin, an inosine 5'-monophosphate dehydrogenase inhibitor analogue of selenazofurin

Journal of Medicinal Chemistry

Volumn 40, Issue 11, 1997, Pages 1731-1737

  Franchetti, Palmarisa ^a   Cappellacci, Loredana ^a   Sheikha, Ghassan Abu ^a   Jayaram, Hiremagalur N ^b   Gurudutt, Vivek V ^b   Sint, Thaw ^b   Schneider, Bryan P ^b   Jones, William D ^c   Goldstein, Barry M ^d   Perra, Graziella ^e   De Montis, Antonella ^e   Loi, Anna Giulia ^e   La Colla, Paolo ^e   Grifantini, Mario ^a  

^a UNIVERSITY OF CAMERINO   (Italy)

^b INDIANA UNIVERSITY   (United States)

^c UNIVERSITY OF ROCHESTER   (United States)

^d UNIVERSITY OF ROCHESTER MEDICAL CENTER   (United States)

^e UNIVERSITY OF CAGLIARI   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

INOSINATE DEHYDROGENASE; INOSINATE DEHYDROGENASE INHIBITOR; SELENAZOFURIN; SELENOPHENFURIN; THIAZOLE DERIVATIVE; THIOPHENE DERIVATIVE; TIAZOFURIN; UNCLASSIFIED DRUG;

ANTINEOPLASTIC ACTIVITY; ARTICLE; CATALYSIS; CELL PROLIFERATION; DRUG STRUCTURE; DRUG SYNTHESIS; ENZYME ACTIVITY; GLYCOSYLATION; LEUKEMIA; LYMPHOMA; SOLID TUMOR; STRUCTURE ACTIVITY RELATION;

ANIMALS; ANTINEOPLASTIC AGENTS; CELL DIVISION; COMPUTER SIMULATION; CRYSTALLOGRAPHY, X-RAY; ENZYME INHIBITORS; GUANOSINE TRIPHOSPHATE; HUMANS; IMP DEHYDROGENASE; INOSINE MONOPHOSPHATE; LEUKEMIA; LYMPHOMA; MAGNETIC RESONANCE SPECTROSCOPY; MICE; MODELS, MOLECULAR; MOLECULAR STRUCTURE; NEOPLASMS; ORGANOSELENIUM COMPOUNDS; RIBONUCLEOSIDES; TUMOR CELLS, CULTURED;

EID: 0030976204     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm960864o     Document Type: Article

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