Antitumor agents. 174. 2',3',4',5,6,7-Substituted 2-phenyl-1,8- naphthyridin-4-ones: Their synthesis, cytotoxicity, and inhibition of tubulin polymerization

Journal of Medicinal Chemistry

Volumn 40, Issue 14, 1997, Pages 2266-2275

  Chen, Ke ^a   Kuo, Sheng Chu ^b   Hsieh, Ming Chieh ^b   Mauger, Anthony ^c   Lin, Chii M ^c   Hamel, Ernest ^c   Lee, Kuo Hsiung ^a  

^a UNIVERSITY OF NORTH CAROLINA   (United States)

^b CHINA MEDICAL UNIVERSITY   (Taiwan)

^c NATIONAL CANCER INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

2 (3 METHOXYPHENYL) 6 (1 PYRROLIDINYL) 4 QUINOLONE; 2 PHENYL 1,8 NAPHTHYRIDIN 4 ONE DERIVATIVE; 2 PHENYLPYRIDO[1,2 A]PYRIMIDIN 4 ONE DERIVATIVE; ANTINEOPLASTIC AGENT; COLCHICINE; COMBRETASTATIN A4; CORNIGERINE; PODOPHYLLOTOXIN; STEGANACIN; TUBULIN; UNCLASSIFIED DRUG;

ANTINEOPLASTIC ACTIVITY; ARTICLE; CANCER INHIBITION; CYTOTOXICITY; DRUG MECHANISM; DRUG POTENCY; POLYMERIZATION; STRUCTURE ACTIVITY RELATION;

ANIMALS; ANTINEOPLASTIC AGENTS; CELL SURVIVAL; DRUG SCREENING ASSAYS, ANTITUMOR; FEMALE; HUMANS; INDICATORS AND REAGENTS; KB CELLS; MAGNETIC RESONANCE SPECTROSCOPY; MALE; MICE; NAPHTHYRIDINES; SOFTWARE; STRUCTURE-ACTIVITY RELATIONSHIP; TUBULIN; TUMOR CELLS, CULTURED;

EID: 0030738726     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm960858s     Document Type: Article

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