Kinetic mechanism of active site assembly and chemical catalysis of DNA polymerase β

Biochemistry

Volumn 50, Issue 45, 2011, Pages 9865-9875

  Balbo, Paul B ^a   Wang, Eric Chun Wei ^a,b   Tsai, Ming Daw ^a,b  

^a INSTITUTE OF BIOLOGICAL CHEMISTRY   (Taiwan)

^b NATIONAL TAIWAN UNIVERSITY   (Taiwan)

Author keywords

[No Author keywords available]

Indexed keywords

ABSORBANCES; ACTIVE SITE; ACTIVE SITE RESIDUES; CHEMICAL CATALYSIS; COMPUTATIONAL STUDIES; CONFORMATIONAL CHANGE; COOPERATIVITY; COORDINATING LIGANDS; DISCRETE STEP; DNA POLYMERASE; GENERAL BASE CATALYSIS; HIGH PH; KINETIC MECHANISM; KINETIC MODELS; KINETIC SIMULATION; PH DEPENDENCE; PH-DEPENDENT; PROTONIC; RATE LIMITING; STOPPED FLOW; SUBDOMAIN; TRANSIENT STATE KINETICS;

CATALYSIS; COMPUTER SIMULATION; CONFORMATIONS; DNA; PH EFFECTS; POLYMERS; PROTONS;

KINETICS;

DEOXYADENOSINE TRIPHOSPHATE; DNA DIRECTED DNA POLYMERASE BETA; MAGNESIUM ION;

ARTICLE; CATALYSIS; ENZYME KINETICS; FLOW KINETICS; FLUORESCENCE ANALYSIS; PH MEASUREMENT; PRIORITY JOURNAL; PROTON TRANSPORT;

ANIMALS; BASE SEQUENCE; CATALYTIC DOMAIN; DEOXYADENINE NUCLEOTIDES; DNA; DNA POLYMERASE BETA; HYDROGEN-ION CONCENTRATION; KINETICS; LIGANDS; MAGNESIUM; MODELS, MOLECULAR; PROTEIN CONFORMATION; PROTEIN STRUCTURE, TERTIARY; RATS; RECOMBINANT PROTEINS;

EID: 80755156306     PISSN: 00062960     EISSN: 15204995     Source Type: Journal    
DOI: 10.1021/bi200954r     Document Type: Article

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