Design, synthesis and biological evaluation of peptidyl- vinylaminophosphonates as novel cysteine protease inhibitors

Bioorganic and Medicinal Chemistry

Volumn 19, Issue 23, 2011, Pages 7129-7135

  Bhattacharya, Asish K ^a   Rana, Kalpeshkumar C ^a  

^a NATIONAL CHEMICAL LABORATORY   (India)

Author keywords

Cysteine; Inhibitor design; Protease inhibitors; Synthesis; Tsuji Trost reaction; Vinylaminophosphonates

Indexed keywords

CYSTEINE PROTEINASE INHIBITOR; PAPAIN; PEPTIDYL VINYLAMINOPHOSPHONIC ACID DERIVATIVE; PHOSPHONIC ACID DERIVATIVE; UNCLASSIFIED DRUG;

ARTICLE; CHEMICAL REACTION; CONCENTRATION RESPONSE; COUPLING REACTION; DRUG CLASSIFICATION; DRUG DESIGN; DRUG SYNTHESIS; ENZYME INHIBITION; ENZYME INHIBITOR INTERACTION; IC 50; IN VITRO STUDY; INFRARED SPECTROSCOPY; REACTION ANALYSIS; TSUJI TROST REACTION;

CYSTEINE PROTEINASE INHIBITORS; HUMANS; MODELS, MOLECULAR; MOLECULAR STRUCTURE; PEPTIDES; PHOSPHONIC ACIDS; SPECTROSCOPY, FOURIER TRANSFORM INFRARED; STRUCTURE-ACTIVITY RELATIONSHIP; VINYL COMPOUNDS;

EID: 80655136959     PISSN: 09680896     EISSN: 14643391     Source Type: Journal    
DOI: 10.1016/j.bmc.2011.09.058     Document Type: Article

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