Peptidyl epoxides extended in the P′ direction as cysteine protease inhibitors: Effect on affinity and mechanism of inhibition

Bioorganic and Medicinal Chemistry

Volumn 16, Issue 19, 2008, Pages 9032-9039

  Perlman, Nurit ^a   Hazan, Maya ^a   Shokhen, Michael ^a   Albeck, Amnon ^a  

^a BAR ILAN UNIVERSITY   (Israel)

Author keywords

Cathepsin B; Endo peptidyl epoxides; Enzyme inhibitors; Papain; Peptidomimetics; Structure activity relationships

Indexed keywords

CATHEPSIN B; CYSTEINE PROTEINASE INHIBITOR; EPOXIDE; PAPAIN; PEPTIDYL EPOXIDE DERIVATIVE; UNCLASSIFIED DRUG;

ARTICLE; BINDING AFFINITY; COMPETITIVE INHIBITION; COMPUTER MODEL; ENZYME ACTIVE SITE; ENZYME INHIBITOR INTERACTION; MOLECULAR DOCKING; MOLECULAR MODEL; STRUCTURE ACTIVITY RELATION;

CATALYTIC DOMAIN; CATHEPSIN B; CYSTEINE PROTEINASE INHIBITORS; EPOXY COMPOUNDS; PAPAIN; PEPTIDES; PROTEIN CONFORMATION; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 52949154630     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmc.2008.08.031     Document Type: Article

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