Rational design of aziridine-containing cysteine protease inhibitors with improved potency: Studies on inhibition mechanism

ChemMedChem

Volumn 1, Issue 9, 2006, Pages 1021-1028

  Vicik, Radim ^a   Helten, Holger ^a   Schirmeister, Tanja ^a   Engels, Bernd ^a  

^a UNIVERSITY OF WÜRZBURG   (Germany)

Author keywords

Cysteine proteases; Inhibitors; Quantum chemical computations

Indexed keywords

AZIRIDINE DERIVATIVE; CYSTEINE PROTEINASE INHIBITOR; DIMETHYL SULFOXIDE; NITROGEN; PROTON; SOLVENT;

ARTICLE; DIALYSIS; DRUG DESIGN; ENTROPY; KINETICS; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; SYNTHESIS; THERMODYNAMICS;

AZIRIDINES; CYSTEINE PROTEINASE INHIBITORS; DIALYSIS; DIMETHYL SULFOXIDE; DRUG DESIGN; ENTROPY; KINETICS; MAGNETIC RESONANCE SPECTROSCOPY; NITROGEN; PROTONS; SOLVENTS; THERMODYNAMICS;

EID: 33749002536     PISSN: 18607179     EISSN: 18607187     Source Type: Journal    
DOI: 10.1002/cmdc.200600081     Document Type: Article

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