Antimalarial activity of thiosemicarbazones and purine derived nitriles

Bioorganic and Medicinal Chemistry Letters

Volumn 19, Issue 13, 2009, Pages 3546-3549

  Mallari, Jeremy P ^a,b   Guiguemde, Wendyam A ^b   Guy, R Kiplin ^b  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b ST JUDE CHILDREN S RESEARCH HOSPITAL   (United States)

Author keywords

Cysteine protease inhibitor; Falcipain; Malaria; Purine nitrile; Thiosemicarbazone

Indexed keywords

CHLOROQUINE; CYSTEINE PROTEINASE; CYSTEINE PROTEINASE INHIBITOR; FALCIPAIN 2; MOLECULAR SCAFFOLD; NITRILE; PURINE DERIVATIVE; THIOSEMICARBAZONE DERIVATIVE;

ANTIMALARIAL ACTIVITY; ANTIMALARIAL DRUG RESISTANCE; ARTICLE; CELL MEMBRANE PERMEABILITY; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG PENETRATION; NONHUMAN; PLASMODIUM; STRUCTURE ACTIVITY RELATION;

ANIMALS; ANTIMALARIALS; CYSTEINE PROTEINASE INHIBITORS; NITRILES; PLASMODIUM FALCIPARUM; PURINES; THIOSEMICARBAZONES;

EID: 66349087286     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2009.04.142     Document Type: Article

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