3-Acylamino-azetidin-2-one as a novel class of cysteine proteases inhibitors

Bioorganic and Medicinal Chemistry Letters

Volumn 13, Issue 1, 2003, Pages 139-141

  Zhou, Nian E ^a   Guo, Deqi ^a   Thomas, George ^a   Reddy, Andhe V N ^a   Kaleta, Jadwiga ^a   Purisima, Enrico ^b   Menard, Robert ^b   Micetich, Ronald G ^a   Singh, Rajeshwar ^a  

^a NAEJA Pharmaceutical Inc   (Canada)

^b NATIONAL RESEARCH COUNCIL CANADA   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

3 ACYLAMINOAZETIDIN 2 ONE; BETA LACTAM; CATHEPSIN B; CATHEPSIN K; CATHEPSIN L; CATHEPSIN S; CYSTEINE; CYSTEINE PROTEINASE; CYSTEINE PROTEINASE INHIBITOR; THIOL; UNCLASSIFIED DRUG; AZETIDINE DERIVATIVE; CATHEPSIN; LACTAM; LEUKOCYTE ELASTASE;

ARTICLE; DRUG POTENCY; ENZYME INHIBITION; IC 50; CHEMISTRY; DRUG ANTAGONISM; DRUG DESIGN; HUMAN; STRUCTURE ACTIVITY RELATION; SYNTHESIS;

AZETIDINES; CATHEPSIN B; CATHEPSINS; CYSTEINE ENDOPEPTIDASES; CYSTEINE PROTEINASE INHIBITORS; DRUG DESIGN; HUMANS; INHIBITORY CONCENTRATION 50; LACTAMS; LEUKOCYTE ELASTASE; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 0037421033     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0960-894X(02)00831-4     Document Type: Article

References (43)

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