2′-Methoxy-6-methylflavone: A novel anxiolytic and sedative with subtype selective activating and modulating actions at GABA A receptors

British Journal of Pharmacology

Volumn 165, Issue 4, 2012, Pages 880-896

  Karim, Nasiara ^a   Curmi, John ^c   Gavande, Navnath ^a   Johnston, Graham Ar ^b   Hanrahan, Jane R ^a   Tierney, M Louise ^c   Chebib, Mary ^a  

^a UNIVERSITY OF SYDNEY   (Australia)

^b University of Sydney   (Australia)

^c Biology and Environment   (Australia)

Author keywords

1 and 2 containing GABA A receptors; anxiolytic agents; dissociated hippocampal neurons; flavonoids; GABA ( aminobutyric acid); GABA A receptors; sedative effects; Xenopus oocytes

Indexed keywords

2' METHOXY 6 METHYLFLAVONE; 3 AMINO 2 (3 CARBOXYPROPYL) 6 (4 METHOXYPHENYL)PYRIDAZINIUM BROMIDE; 4 AMINOBUTYRIC ACID; 4 AMINOBUTYRIC ACID A RECEPTOR; 4 AMINOBUTYRIC ACID A RECEPTOR ALPHA2BETA2; ANXIOLYTIC AGENT; BARBITURIC ACID DERIVATIVE; BICUCULLINE; CHLORIDE ION; DIAZEPAM; FLAVONOID; FLUMAZENIL; RECOMBINANT PROTEIN; SEDATIVE AGENT; UNCLASSIFIED DRUG; 2'-METHOXY-6-METHYLFLAVONE; BENZODIAZEPINE RECEPTOR AFFECTING AGENT; FLAVONE DERIVATIVE; HYPNOTIC SEDATIVE AGENT;

ANIMAL BEHAVIOR; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANXIETY DISORDER; ARTICLE; CHLORIDE CONDUCTANCE; CHLORIDE CURRENT; CONTROLLED STUDY; DRUG MEGADOSE; ELECTRODE; HIPPOCAMPUS; LIGAND BINDING; MALE; MAZE TEST; MUSCLE RELAXATION; NERVE CELL; NEWBORN; NONHUMAN; OOCYTE; PATCH CLAMP; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT; SEDATION; TRANQUILIZING ACTIVITY; VOLTAGE CLAMP; XENOPUS; ANIMAL; BAGG ALBINO MOUSE; CELL CULTURE; CYTOLOGY; DRUG EFFECT; HUMAN; MOTOR ACTIVITY; MOUSE; PHYSIOLOGY; WISTAR RAT; XENOPUS LAEVIS;

ANIMALS; ANIMALS, NEWBORN; ANTI-ANXIETY AGENTS; BEHAVIOR, ANIMAL; CELLS, CULTURED; FLAVONES; GABA MODULATORS; HIPPOCAMPUS; HUMANS; HYPNOTICS AND SEDATIVES; MALE; MAZE LEARNING; MICE; MICE, INBRED BALB C; MOTOR ACTIVITY; NEURONS; OOCYTES; RATS; RATS, WISTAR; RECEPTORS, GABA-A; XENOPUS LAEVIS;

EID: 80555136104     PISSN: 00071188     EISSN: 14765381     Source Type: Journal    
DOI: 10.1111/j.1476-5381.2011.01604.x     Document Type: Article

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