Refinement and evaluation of a pharmacophore model for flavone derivatives binding to the benzodiazepine site of the GABAA receptor

Journal of Medicinal Chemistry

Volumn 45, Issue 19, 2002, Pages 4188-4201

  Kahnberg, Pia ^a   Lager, Erik ^a   Rosenberg, Celia ^a   Schougaard, Jette ^b   Camet, Linda ^a   Sterner, Olov ^a   Nielsen, Elsebet Østergaard ^c   Nielsen, Mogens ^b   Liljefors, Tommy ^b  

^a LUND UNIVERSITY   (Sweden)

^b UNIVERSITY OF COPENHAGEN   (Denmark)

^c NEUROSEARCH A S   (Denmark)

Author keywords

[No Author keywords available]

Indexed keywords

4 AMINOBUTYRIC ACID A RECEPTOR; 5' BROMO 2' HYDROXY 6 METHYLFLAVONE; FLAVONE DERIVATIVE; LIGAND; UNCLASSIFIED DRUG;

ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DRUG BINDING SITE; DRUG DESIGN; DRUG RECEPTOR BINDING; DRUG SCREENING; DRUG STRUCTURE; DRUG SYNTHESIS; EXPERIMENTAL MODEL; HYDROGEN BOND; INHIBITION KINETICS; INTERMETHOD COMPARISON; MALE; NONHUMAN; PHARMACOPHORE; QUANTITATIVE STRUCTURE ACTIVITY RELATION; RAT; RECEPTOR AFFINITY; STEREOSPECIFICITY; STRUCTURE ANALYSIS;

ANIMALS; BINDING SITES; CEREBRAL CORTEX; COMBINATORIAL CHEMISTRY TECHNIQUES; FLAVONOIDS; HYDROGEN BONDING; MALE; MODELS, MOLECULAR; MOLECULAR CONFORMATION; QUANTITATIVE STRUCTURE-ACTIVITY RELATIONSHIP; RATS; RATS, WISTAR; RECEPTORS, GABA-A;

EID: 0037068477     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm020839k     Document Type: Article

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