Hippocampal GABA(A) channel conductance increased by diazepam

Nature

Volumn 388, Issue 6637, 1997, Pages 71-75

  Eghbali, M ^a   Curmi, J P ^a   Birnir, B ^a   Gage, P W ^a  

^a Biology and Environment   (Australia)

Author keywords

[No Author keywords available]

Indexed keywords

4 AMINOBUTYRIC ACID A RECEPTOR; CHLORIDE CHANNEL;

AMBIENT AIR; ARTICLE; CENTRAL NERVOUS SYSTEM; CONDUCTANCE; GABAERGIC TRANSMISSION; HIPPOCAMPUS; PRIORITY JOURNAL; SYNAPTIC INHIBITION;

ANIMALS; CELLS, CULTURED; DIAZEPAM; DOSE-RESPONSE RELATIONSHIP, DRUG; ELECTRIC CONDUCTIVITY; FLUMAZENIL; GABA MODULATORS; HIPPOCAMPUS; NEURONS; RATS; RECEPTORS, GABA-A;

EID: 0030848203     PISSN: 00280836     EISSN: None     Source Type: Journal    
DOI: 10.1038/40404     Document Type: Article

References (23)

1. A receptor/chloride channel complex in anesthesia. Anesthesiology 78, 757-776 (1993).
2. Study, R. E. & Barker, J. L. Diazepam and (-)-pentabarbital fluctuation analysis reveals different mechanisms for potentiation of γ-aminobutyric add responses in cultured central neurons. Proc. Natl Acad. Sci. USA 78, 7180-7184 (1981).
3. A receptor channels of mouse spinal neurones in culture. J. Physiol. (Lond.) 475, 69-82 (1994).
4. A channels in rat dentate gyrus. J. Membr. Biol. 142, 93-102 (1994).
5. Premkumar, L. S., Chung, S.-H. & Gage, P. W. GABA-induced potassium channels in cultured neurons. Proc. R. Soc. Lond. B 241, 153-158 (1990).
6. Curmi, J. P., Premkumar, L. S., Birnir, B. & Gage, P. W. The influence of membrane potential on chloride channels activated by GABA in rat cultured hippocampal neurones. J. Membr. Biol. 136, 2673-280 (1993).
7. Fatima-Shad, K. & Barry, P. H. A patch-clamp study of GABA- and strychnine-sensitive glycine-activated currents in post-natal tissue-cultured hippocampal neurons. Proc. R. Soc. Lond. B 250, 99-105 (1992).
8. Gage, P. W. & Chung, S. Influence of membrane potential on conductance sublevels of chloride channels activated by GABA. Proc. R. Soc. Lond. B 255, 167-172 (1994).
9. Gray, R. & Johnston, D. Rectification of single GABA-gated chloride channels in adult hippocampal neurons. J. Neurophysiol. 54, 134-142 (1985).
10. A receptor insights from comparison of native and recombinant subunit assemblies. Can. J. Physiol. Pharmacol. 69, 1057-1063 (1991).
11. A receptors. Trends Pharmacol. Sci. 16, 162-168 (1995).
12. - channels recorded from membrane patches of neonatal rat cortical neurons in culture. J. Pharmacol. Exp. Ther. 243, 1195-1201 (1987).
13. Twyman, R. E., Rogers, C. J. & MacDonald, R. L. Differential regulation of γ-aminobutyric acid receptor channels by diazepam and phenobarbital. Ann. Neurol. 25, 213-220 (1989).
14. Miller, C. Open-state substructure of single chloride channels from Torpedo electroplax. Phil. Trans. R. Soc., Lond. B 299, 401-411 (1982).
15. Middleton, R. E., Pheasant, D. J. & Miller, C. Homodimeric architecture of a ClC-type chloride ion channel. Nature 383, 337-340 (1996).
16. Ludewig, W., Pusch, M. & Jentsch, T. J. Two physically distinct pores in the dimeric ClC-0 chloride channel. Nature 383, 340-343 (1996).
17. Matsuda, H. Open-state substructure of inwardly rectifying potassium channels revealed by magnesium block in guinea-pig heart cells. J. Physiol. (Lond.) 397, 237-258 (1988).
18. + block in guinea-pig heart cells. J. Physiol. (Lond.) 413, 139-157 (1989).
19. Segal, M. & Barker, J. L. Rat hippocampal neurons in culture: voltage-clamp analysis of inhibitory synaptic connections. J. Neurophysiol. 52, 469-487 (1984).
20. A receptor-mediated Ispontaneous inhibitory postsynaptic currents in hippocampal neurons. Proc. Natl Acad. Sci. USA 78, 7180-7184 (1992).
21. Mody, I., De Doninck, Y., Otis, T. S. & Soltesz, I. Bridging the cleft at GABA synapses in the brain. Trends Neurosci. 17, 517-525 (1994).
22. Tossman, U., Jonsson, G. & Understedt, U. Regional distribution and extracellular levels of amino acids in rat central nervous system. Acta Physiol. Scand. 127, 533-545 (1986).
23. Lerma, J., Herranz, A. S., Herreras, O., Abraira, V. & Martin del rio, R. In vivo determination of extracellular concentration of amino acids in the rat hippocampus. A method based on brain dialysis and computerized analysis. Brain Res. 384, 145-155 (1986).