Retrochalcone derivatives are positive allosteric modulators at synaptic and extrasynaptic GABA A receptors in vitro

British Journal of Pharmacology

Volumn 162, Issue 6, 2011, Pages 1326-1339

  Jiang, Ruotian ^a   Miyamoto, Akiko ^b   Martz, Adeline ^a   Specht, Alexandre ^a   Ishibashi, Hitoshi ^b   Kueny Stotz, Marie ^a   Chassaing, Stefan ^a   Brouillard, Raymond ^a   De Carvalho, Lia Prado ^a   Goeldner, Maurice ^a   Nabekura, Junichi ^b   Nielsen, Mogens ^c   Grutter, Thomas ^a  

^a UNIVERSITÉ DE STRASBOURG   (France)

^b NATIONAL INSTITUTE FOR PHYSIOLOGICAL SCIENCES   (Japan)

^c UNIVERSITY OF COPENHAGEN   (Denmark)

Author keywords

allosteric modulators; flavylium salts; GABAA ion channels; trans retrochalcones

Indexed keywords

3ALPHA,21 DIHYDROXY 5ALPHA PREGNAN 20 ONE; 4 AMINOBUTYRIC ACID; 4 AMINOBUTYRIC ACID A RECEPTOR; 4,3' DIMETHOXYCHALCONE; 6 BROMO 4' METHOXYRETROCHALCONE; 6, 4' DIMETHOXYRETROCHALCONE; BENZODIAZEPINE RECEPTOR AFFECTING AGENT; DIAZEPAM; LORECLEZOLE; PENTOBARBITAL; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; BRAIN ELECTROPHYSIOLOGY; CELL STRAIN HEK293; CONTROLLED STUDY; DRUG EFFECT; GENE MUTATION; GENETIC TRANSFECTION; HIPPOCAMPAL CA1 REGION; IN VITRO STUDY; INHIBITORY POSTSYNAPTIC POTENTIAL; NONHUMAN; PATCH CLAMP; PRIORITY JOURNAL; PROTEIN EXPRESSION; PYRAMIDAL NERVE CELL; RAT; THALAMUS;

ANIMALS; BENZODIAZEPINES; CA1 REGION, HIPPOCAMPAL; CHALCONES; GAMMA-AMINOBUTYRIC ACID; HEK293 CELLS; HUMANS; NEUROTRANSMITTER AGENTS; PATCH-CLAMP TECHNIQUES; PLASMIDS; PYRAMIDAL CELLS; RATS; RATS, WISTAR; RECEPTORS, GABA-A; STEREOISOMERISM; VENTRAL THALAMIC NUCLEI;

EID: 79951999076     PISSN: 00071188     EISSN: 14765381     Source Type: Journal    
DOI: 10.1111/j.1476-5381.2010.01142.x     Document Type: Article

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