Degradation products analysis of an Fc fusion protein using LC/MS methods

International Journal of Biological Macromolecules

Volumn 44, Issue 1, 2009, Pages 81-85

  Ren, Da ^a   Ratnaswamy, Gayathri ^a   Beierle, Jill ^a   Treuheit, Michael J ^a   Brems, David N ^a   Bondarenko, Pavel V ^a  

^a AMGEN INC   (United States)

Author keywords

Deamidation; Fc fusion protein; Formulation; LC MS; Oxidation

Indexed keywords

ASPARAGINE; HYBRID PROTEIN; IMMUNOGLOBULIN FC FRAGMENT; METHIONINE; POTASSIUM DIHYDROGEN PHOSPHATE;

AMINO ACID SEQUENCE; ANION EXCHANGE CHROMATOGRAPHY; ARTICLE; CONTROLLED STUDY; DEAMINATION; ELECTROSPRAY MASS SPECTROMETRY; ESCHERICHIA COLI; FREEZE DRYING; GLYCOSYLATION; LIQUID; LIQUID CHROMATOGRAPHY; NONHUMAN; OXIDATION; PEPTIDE MAPPING; PROTEIN ANALYSIS; PROTEIN DEGRADATION; PROTEIN DOMAIN; PROTEIN EXPRESSION; REVERSED PHASE HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; TIME OF FLIGHT MASS SPECTROMETRY;

EID: 57749188897     PISSN: 01418130     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ijbiomac.2008.10.006     Document Type: Article

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