Structural characterization of a recombinant monoclonal antibody by electrospray time-of-flight mass spectrometry

Pharmaceutical Research

Volumn 22, Issue 8, 2005, Pages 1338-1349

  Wang, Lintao ^a   Amphlett, Godfrey ^a   Lambert, John M ^a   Blättler, Walter ^a   Zhang, Wei ^a  

^a IMMUNOGEN INC   (United States)

Author keywords

Electrospray time of flight mass spectrometry; Monoclonal antibody; Protein characterization; Structural post translational modifications

Indexed keywords

ASPARTIC ACID; HUN 901; IMMUNOGLOBULIN G1 ANTIBODY; LYSINE; MONOCLONAL ANTIBODY; PROTEINASE; PYROGLUTAMIC ACID; RECOMBINANT ANTIBODY; TRYPSIN;

ALKYLATION; AMINO TERMINAL SEQUENCE; ANIMAL CELL; ARTICLE; CARBOXY TERMINAL SEQUENCE; CHO CELL; DEAMINATION; DEGLYCOSYLATION; DRUG STRUCTURE; ELECTROSPRAY MASS SPECTROMETRY; GLYCOSYLATION; HEAVY CHAIN; LIGHT CHAIN; LIQUID CHROMATOGRAPHY; MASS SPECTROMETRY; MOLECULAR WEIGHT; NONHUMAN; PEPTIDE MAPPING; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN DEGRADATION; PROTEIN PROCESSING; PROTEIN STRUCTURE; TIME OF FLIGHT MASS SPECTROMETRY;

ALKYLATION; AMINO ACID SEQUENCE; ANTIBODIES, MONOCLONAL; ANTIGENS, CD56; ANTINEOPLASTIC AGENTS; ASPARTIC ENDOPEPTIDASES; CELL ADHESION MOLECULES; CHROMATOGRAPHY, GEL; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; HYDROLYSIS; MOLECULAR SEQUENCE DATA; OXIDATION-REDUCTION; PEPTIDE MAPPING; RECOMBINANT PROTEINS; SPECTROMETRY, MASS, ELECTROSPRAY IONIZATION; SPECTROPHOTOMETRY, ULTRAVIOLET; TRYPSIN;

EID: 23844454990     PISSN: 07248741     EISSN: None     Source Type: Journal    
DOI: 10.1007/s11095-005-5267-7     Document Type: Article

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