Determination of the origin of the N termina pyro-glutamate variation in monoclonal antibodies using model peptides

Biotechnology and Bioengineering

Volumn 97, Issue 3, 2007, Pages 544-553

  Dick Jr , Lawrence W ^a   Kim, Catherine ^a   Qiu, Difei ^a   Cheng, Kuang Chuan ^a  

^a MEDAREX INC   (United States)

Author keywords

Bioreactor; Post translational modification; Pyro glutamate; Pyro glutamic acid; Pyro Q; Recombinant antibody

Indexed keywords

BIOREACTORS; BIOSYNTHESIS; CYCLIZATION; MONOCLONAL ANTIBODIES; ORGANIC ACIDS;

POST-TRANSLATIONAL MODIFICATION; PYRO-GLUTAMATE; PYRO-GLUTAMIC ACID; PYRO-Q; RECOMBINANT ANTIBODY;

PEPTIDES;

GLUTAMINE; MONOCLONAL ANTIBODY; PYROGLUTAMIC ACID;

AMINO TERMINAL SEQUENCE; ARTICLE; CHEMICAL STRUCTURE; CYCLIZATION; LIQUID CHROMATOGRAPHY; MASS SPECTROMETRY;

ANTIBODIES, MONOCLONAL; CHEMISTRY, PHARMACEUTICAL; CYCLIZATION; GLUTAMIC ACID; HYDROGEN-ION CONCENTRATION; KINETICS; PEPTIDES; PROTEIN CONFORMATION; RECOMBINANT PROTEINS;

EID: 34249777508     PISSN: 00063592     EISSN: 10970290     Source Type: Journal    
DOI: 10.1002/bit.21260     Document Type: Article

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