Identification and quantification of degradations in the Asp-Asp motifs of a recombinant monoclonal antibody

Journal of Pharmaceutical and Biomedical Analysis

Volumn 47, Issue 1, 2008, Pages 23-30

  Xiao, Gang ^a   Bondarenko, Pavel V ^a  

^a AMGEN INC   (United States)

Author keywords

Immunoglobulin gamma antibody; Isoaspartate; Mass spectrometry; Peptide bond hydrolysis; Reversed phase liquid chromatography

Indexed keywords

ASPARTIC ACID; IMMUNOGLOBULIN G2; ISOASPARTIC ACID; MONOCLONAL ANTIBODY; POLYPEPTIDE; RECOMBINANT ANTIBODY;

AMINO TERMINAL SEQUENCE; ARTICLE; GEL PERMEATION CHROMATOGRAPHY; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; ISOMERIZATION; MATRIX ASSISTED LASER DESORPTION IONIZATION TIME OF FLIGHT MASS SPECTROMETRY; PRIORITY JOURNAL; PROTEIN MOTIF;

AMINO ACID MOTIFS; ANTIBODIES, MONOCLONAL; CHROMATOGRAPHY, GEL; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; COMPLEMENTARITY DETERMINING REGIONS; DIMERIZATION; DRUG STABILITY; RECOMBINANT PROTEINS; SPECTROMETRY, MASS, MATRIX-ASSISTED LASER DESORPTION-IONIZATION; TEMPERATURE;

EID: 41549106299     PISSN: 07317085     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jpba.2007.11.050     Document Type: Article

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