Trap for MAbs: Characterization of intact monoclonal antibodies using reversed-phase HPLC on-line with ion-trap mass spectrometry

Journal of the American Society for Mass Spectrometry

Volumn 16, Issue 3, 2005, Pages 307-311

  LePavel, John C ^a   Bondarenko, V ^a  

^a AMGEN INC   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ACETONITRILE; CARBOXYLIC ACIDS; CHARACTERIZATION; ELECTRIC POTENTIAL; ETHANOL; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; MACROMOLECULES; MASS SPECTROMETERS; ONLINE SYSTEMS; OPTIMIZATION; WATER;

ION-TRAP MASS SPECTROMETERS (IT-MS); MONOCLONAL ANTIBODIES (MABS); NONTRADITIONAL SOLVENT SYSTEMS; REVERSED-PHASE HIGH PERFORMANCE LIQUID CHROMATOGRAPHY (RP-HPLC);

ANTIBODIES;

2 PROPANOL; ACETONITRILE; ALCOHOL; FORMIC ACID; HEXOSE; IMMUNOGLOBULIN G ANTIBODY; MONOCLONAL ANTIBODY; SOLVENT; WATER;

ANALYTIC METHOD; ARTICLE; ION TRAP MASS SPECTROMETRY; MACROMOLECULE; MOLECULAR WEIGHT; ONLINE SYSTEM; PROTEIN ANALYSIS; REVERSED PHASE HIGH PERFORMANCE LIQUID CHROMATOGRAPHY;

ANTIBODIES, MONOCLONAL; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; IMMUNOGLOBULIN G; MASS SPECTROMETRY; MOLECULAR WEIGHT; SOLVENTS;

EID: 14744293331     PISSN: 10440305     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jasms.2004.11.004     Document Type: Article

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